Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Genysis Ventures is doing a wonderful job at driving this company into the ground. Dr. Friesen should put his accomplishments at Medicure on a linked-in page...so other biotechs looking for his expertise can attain a market cap below $2.5million.
Let's see...cash has been reduced to $59k from $253k the prior qtr. Burning through $84k per month. Inventories of finished product have doubled while sales have been cut in half. The trial (and the costs associated with it) continue as normal.
Does anyone have a gun so i can shoot myself...thanks!
MCUJF has alot of baggage. They took out a $5mm loan in order to resolve the Birmingham debt settlement; principal w/interest payments due in 2014. Birmingham is seriously underwater with the shares they took as part of the settlement; especially with the "share consolidation." Now, with the cash levels at historic lows and their inability to turn a profit...this company is experiencing another event that questions their ability to survive.
No trial updates, dwindling cash reserves, nothing expected..i am kicking myself when they released the news of the debt settlement when shares hit $0.07-$0.08.
Correvio would be able to go public and allow its private shareholders an opportunity to sell into a public market. So it would be good for shareholders of Correvio, and in the short-term, the market would react, and likely move up for MCUJF shareholders.
Funny you should mention a reverse merger... that very thought popped into my mind last week, when I was looking at all the insider buying that Medicure execs have been doing lately.
The CEO especially, has been buying shares hand over fist on the open market for some time now (he has bought 41,000 shares on the TSX this month alone, according to Canadianinsider).
Of course, there are many other reasons for insider buying, and this alone does not indicate any reverse mergers; just mere speculation on my part.
Regardless, if this unlikely event were to happen, as Medicure shareholders, would that be a good thing or a bad thing for us? And would it be a good thing for Correvio?
Good luck,
Sunpillar
MCUJF - A reverse merger with Correvio is one option.
http://www.correvio.com/namechange
Although, their management team is less than average, and has lost more than half of the global business in the past 3 years due to a lack of vision.
http://www.correvio.com/executive_management
MCUJF cash for continuing operations is good through 2013, according to management. We are almost through half of 2013 and cash is dwindling with no plan in raising additional capital. They reduced the share count to 6mm, can they at least find an investor to keep this thing afloat?
The market maker, combined with SRGE's execs general lack of any urgency with this company...are going to be the death blow for the share price. Market maker lo-balls the bid, gets a sell, then decides to raise the bid a few cents off the sale price. With low volume, this tactic can certainly put an end to any potential gains.
One step forward, two steps back. The SP of MCUJ cannot seem to gain any traction. $0.45 is $0.03 a share pre-split. $0.04, which was conceivable back in the day, is a whopping $0.60 a share; no chance in hell.
Currently the bid stands at the $0.01 level; how's that for building shareholder value?
MCUJF - Nice move today. Looks like the bid is moving up a bit.
ACC is this weekend. It is possible that Medicure makes some sort of PR regarding clinical data for AGGRASTAT. Not sure what is being presented this year.
Have to sign in to get the ACC program for this year and do a search on MI and ACS with tirofiban as a keyword.
http://accscientificsession.cardiosource.org/~/link.aspx?_id=6300C21F4A2A43CA9B3F81FFA33B78D6&_z=z
MCUJF - There seems to be nice volume on the TSX. It is very quite on the pink sheet listing. You know that could change quickly.
I think there is a good possibility that there could be promising data from the Tardoxal trial. The only concern I have is the pace at which the trial is enrolling. Way overdue!
If the inclusion criteria are too stringent, then the label, if approved, would be very limited and narrow. Having said that, key is to get label approval for something, so it could start generating revenue for the company.
Hi STE,
Nice to see some chatter here, it's been dreadfully quiet for far too long LOL.
Do you think there is any chance that the Tardoxal trials will yield any positive results for the company? I would think a decent interim report (which is increasingly overdue) would be cause for hope..
I also note that the companies shares on the TSX were up almost 38% today, to close at 40 cents (no news). I wonder if something is cooking?
Cheers
Sunpillar
MCUJF - I too have been highly invested in this company. There is hope, IMO. One thing that would create immediate value, would be a merger of the global businesses. Although, the trend is that the business outside of the US has been shrinking do to the current management.
Thanks. I am heavily invested in this company and have to continually remind myself that this company is not a shell.
I do not have a contact for them. It may be on the internet or may be in the PR that discusses the debt reprieve.
Do you happen to know the contact info of the Birmingham Associates that did the debt reprieve?
I wonder how happy they are about this financial slug of a company.
MCUJF - I agree. Believe me you, they have done everything and nothing at all to help the value of the company decrease to these lows.
If you ever met the management team, you would quickly understand how our investments have been cut in half.
What I find baffling is the need for the reverse split. If you are a Citibank with a gazillion shares oustanding, yet have a solid foundation for which to grow revenues and TRADING VOLUME, then by all means...do a reverse split. This company, with absolute little shareholder or institutional interest, decides instead of working on the fundamentals of the company; approve a reverse split without addressing anything. Sure, the CEO is buying shares, however, the low float and current lack of support in the bid shows the effects of this decision...an already low market cap has been cut in half.
MCUJF - Even if Medicure gets a label addition (European data included), they will need a commercial plan. For the past 4-5 years, their commercial plan has been horrible. And any affiliation with IROKO Cardio, may prove to have little impact on commercial growth.
IROKO Cardio is a private company, so their revenues and sales are not public. Based upon distributor data out of Europe, they have lost more than 50% of their business in the past 3 years. It appears that the group managing the business out of Europe is shitting the bed and may have put the AGGRASTAT brand into a global death spiral.
Global sales of AGGRASTAT were once well over $200M per year. Most of which was in the US. Today, the US does $2M in annual sales, and globally, I would assume that sales are well below $50M annually.
Best in class product, with the worst in industry management.
A $5M investment in 2008, in a clinical trial with relevant endpoints, would have helped to prevent US market erosion.
Neither company was interested at the time. Now any investment in a clinical trial program is a waste. The Phase 2 trial that Medicure is currently sponsoring is a joke at best and will have zero impact on sales growth.
Still holding and hoping for a miracle, but as time passes, the opportunity here is waining.
Medicure bid $0.0497...and the purpose of the reverse split was??
MCUJF - The management of the company appear to be incompetent. Not sure any logical sound business advice will make a difference with them.
If you have met them, you would understand.
Crazy to have the best in class therapy and have a worst in class management crew pouring buckets of water on the deck of the Titanic.
While your at it...why don't you tell them that shares have hit a 52-week low and that the bid has dropped through the floor, slightly above .01 per share pre reverse-split.
MCUJF - Company releasing news, incorrectly, under MCUJD still. Will email them and make them aware.
MCUJF - Waiting on pullback before adding.
poorly designed Phase 2 trial against eptifibatide...
Can you please explain why the trial is poorly designed, thanks
Should have purchased the Toronto-listed shares...rally day for them. How is it insider purchases, an uplisting of their shares and VOLUME goes to the toronto-listing while the US listing sits on the lowly pink sheets, does not trade in tandem with the toronto-listed shares and has no volume to speak of...
MCUJD - With the reverse split and the decline in sales and the poorly designed Phase 2 trial against eptifibatide, I would not add to my portfolio until this pulls back a bit.
Best drug on the market with the biggest bozos running the show.
Only a $105 ask...what the hell is management doing to this stock?
MCUJD - Medicure Inc. (MCUJ: OTC Link)|Symbol Change
Fri, Nov 02, 2012 12:00
Medicure Inc. (MCUJ: OTC Link)
Symbol Change
The symbol, MCUJ, is no longer a valid symbol for Medicure Inc.. As of Fri, Nov 02, 2012, the new trading symbol is MCUJD. You may find a complete list of symbol changes at otcmarkets.com.
MCUJ - Medicure Completes Share Consolidation
Medicure Inc. (QB) (USOTC:MCUJ)
Today : Thursday 1 November 2012
Medicure Inc. ("Medicure" or the "Company") (TSX VENTURE:MPH)(PINKSHEETS:MCUJ), announced today that, further to its news release of September 21, 2012, the TSX Venture Exchange (the "Exchange") has approved the consolidation of the Company's issued and outstanding common shares on the basis of one post-consolidation common share for every fifteen pre-consolidation common shares and the Company has proceeded with the consolidation. Effective at the opening of the market on November 2, 2012, Medicure's shares will commence trading on the Exchange on a consolidated basis under the new CUSIP number 58469E408. The Company's name and trading symbol will not change as a result of the consolidation. The Company will have approximately 12,196,506 common shares issued and outstanding as a result of the consolidation.
Letters of transmittal with respect to the consolidation will be sent to registered shareholders. All registered shareholders of the Company will be required to send their certificates representing pre-consolidation common shares with a properly executed letter of transmittal to the Company's transfer agent, Computershare Investor Services Inc. in Toronto, Ontario ("Computershare") (Shareholder Services - Toll Free (North America) 1-800-564-6253, Overseas 1-514-982-7555 or corporateactions@computershare.com). Shareholders who hold their shares through their broker or other intermediary and do not have actual share certificates registered in their name will not be required to complete and return a letter of transmittal. Additional copies of the letter of transmittal can be obtained through Computershare. All shareholders who duly complete letters of transmittal and submit their pre-consolidation common share certificates to Computershare will receive a Direct Registration Advice representing the number of post-consolidation common shares to which they are entitled to pursuant to the terms of the consolidation.
About Medicure Inc.
Medicure is a specialty pharmaceutical company focused on the development and commercialization of novel small molecule therapeutics. The primary focus of the Company and its subsidiaries is the marketing and distribution of AGGRASTAT® (tirofiban HCl) for acute coronary syndromes in the United States, where it is sold through the Company's US subsidiary, Medicure Pharma, Inc. For more information on Medicure please visit www.medicure.com.
To be added to Medicure's e-mail list, please visit: http://medicure.com/news.html.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
Contacts:
Medicure Inc.
President & COO
888-435-2220
204-488-9823 (FAX)
info@medicure.com
www.medicure.com
MCUJ - Medicure Reports First Quarter Financial Results for Fiscal 2013
Medicure Inc. (QB) (USOTC:MCUJ)
Today : Tuesday 30 October 2012
Medicure Inc. ("Medicure" or the "Company") (TSX VENTURE:MPH)(PINKSHEETS:MCUJ), a specialty pharmaceutical company, today reported its results from operations for the quarter ended August 31, 2012.
First Quarter Highlights:
-- Net revenue from the sale of AGGRASTATr finished product during the
three months ended August 31, 2012 was $0.7 million, compared to $0.4
million for the previous quarter ended May 31, 2012 and $1.1 million for
the same quarter last year;
-- Net loss for three months ended August 31, 2012 was $0.3 million,
compared to a net loss of $1.0 million for the previous quarter and net
income of $23.5 million for the same quarter last year, however the net
income in the same quarter last year primarily relates primarily to a
$23.9 million non-cash gain relating to the settlement of the Company's
long-term debt.
Financial Results
Total net revenue for the three months ended August 31, 2012 was $0.7 million compared to $1.5 million for the three months ended August 31, 2011. Net revenue from the sale of AGGRASTAT finished product for the three months ended August 31, 2012 was $0.7 million compared to $1.1 million for the same quarter last year. The decrease in total revenues compared to the same quarter last year primarily relates to a $0.5 million sale of unfinished AGGRASTAT in the previous year. The decrease in sale of AGGRASTAT finished product corresponds with an overall decline in use of injectable antiplatelet drugs. It is also attributable to increases in discounts to new customers and fluctuations in foreign exchange rates.
Net loss for the quarter was $0.3 million or $0.00 per share, compared to net income of $23.5 million or $0.15 per share in the same quarter a year ago, however the net income in the previous year quarter primarily relates to a $23.9 million non-cash gain relating to the settlement of the Company's long-term debt.
At August 31, 2012, the Company had cash totalling $431,061 compared to $1,124,345 as of May 31, 2012. Cash flows used in operating activities for the three months ended August 31, 2012 were $686,305, compared to cash flows from operating activities of $429,567 for the three months ended August 31, 2011. The increase in utilization of cash in operating activities results from a $0.5 million prepayment for manufacturing of AGGRASTAT finished product.
Corporate Developments
On September 21, 2012, the Company announced that its Board of Directors approved a consolidation of the Company's common shares ("Common Shares") on the basis of fifteen pre-consolidation Common Shares for each one post consolidation Common Share, subject to the approval of the TSX Venture Exchange.
Product Developments
The primary ongoing research and development activity is the development and implementation of a new regulatory, brand and life cycle management strategy for AGGRASTAT.
On October 2, 2012, the Company announced its intention to file a supplemental new drug application (sNDA) for the high dose bolus (HDB) dosing regimen of AGGRASTAT. The Company also announced that the United States Food and Drug Administration (FDA) has granted the Company's request for a waiver of the US $979,400 application fee for the planned sNDA.
On September 26, 2012 the Company announced the development of a transdermal delivery formulation of AGGRASTAT's active ingredient, tirofiban. In vivo proof of principle for the transdermal delivery of therapeutic levels of tirofiban was recently established in animal studies conducted in collaboration with 4P Therapeutics, Inc. (Alpharetta, GA). 4P Therapeutics, a world leader in the research and development of novel transdermal products, has entered into an agreement with the Company's subsidiary, Medicure International, Inc., to further develop transdermal tirofiban.
As previously announced, the Company is currently conducting a 600 patient clinical trial of AGGRASTAT entitled "Shortened Aggrastat Versus Integrilin in Percutaneous Coronary Intervention" (SAVI-PCI). The study is evaluating a contemporary dosage regimen that is outside of the product's current prescribing information.
The Company's primary, non-AGGRASTAT research and development activity is TARDOXAL(TM) for the treatment of Tardive Dyskinesia (TD). A modest amount of capital is being used for an ongoing Phase II clinical study of TARDOXAL, entitled Tardoxal for the Treatment of Tardive Dyskinesia (TEND-TD).
The Company's ability to continue in operation for the foreseeable future remains dependent upon the effective execution of its business development and strategic plans.
All amounts referenced herein are in Canadian dollars unless otherwise noted.
About AGGRASTAT
AGGRASTAT (tirofiban HCl), in combination with heparin, is indicated for the treatment of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy. In this setting, AGGRASTAT has been shown to decrease the rate of a combined endpoint of death, new myocardial infarction or refractory ischemia/repeat cardiac procedure. AGGRASTAT has been studied in a setting that included aspirin and heparin.
Bleeding is the most common complication encountered during therapy with AGGRASTAT. Administration of AGGRASTAT is associated with an increase in bleeding events classified as both major and minor bleeding events by criteria developed by the Thrombolysis in Myocardial Infarction Study group (TIMI). Most major bleeding associated with AGGRASTAT occurs at the arterial access site for cardiac catheterization. Fatal bleedings have been reported. AGGRASTAT should be used with caution in patients with platelet count less than 150,000/mm3, in patients with hemorrhagic retinopathy, and in chronic hemodialysis patients. Because AGGRASTAT inhibits platelet aggregation, caution should be employed when it is used with other drugs that affect hemostasis. The safety of AGGRASTAT when used in combination with thrombolytic agents has not been established. During therapy with AGGRASTAT, patients should be monitored for potential bleeding. When bleeding cannot be controlled with pressure, infusion of AGGRASTAT and heparin should be discontinued.
AGGRASTAT is a parenteral non-peptide, reversible GP IIb/IIIa receptor antagonist that is marketed in the United States by Medicure Pharma, Inc. Please see the AGGRASTAT Prescribing Information for approved indications, dosage regimens and safety related information. The AGGRASTAT dosing regimen and the treatment setting studied in the SAVI-PCI study have not been approved by the FDA.
About Medicure Inc.
Medicure is a specialty pharmaceutical company focused on the development and commercialization of novel small molecule therapeutics. The primary focus of the Company and its subsidiaries is the marketing and distribution of AGGRASTAT (tirofiban HCl) for acute coronary syndromes in the United States, where it is sold through the Company's US subsidiary, Medicure Pharma, Inc. For more information on Medicure please visit www.medicure.com.
To be added to Medicure's e-mail list, please visit:
http://www.medicure.com/news.html
Forward Looking Information: Statements contained in this press release that are not statements of historical fact, including, without limitation, statements containing the words "believes", "may", "plans", "will", "estimates", "continues", "anticipates", "intends", "expects" and similar expressions, may constitute "forward-looking information" within the meaning of applicable Canadian and U.S. federal securities laws (such forward-looking information and forward-looking statements are hereinafter collectively referred to as "forward-looking statements"). Forward-looking statements are based on the current assumptions, estimates, analysis and opinions of management of the Company made in light of its experience and its perception of trends, current conditions and expected developments, as well as other factors which the Company believes to be relevant and reasonable in the circumstances. Inherent in forward-looking statements are known and unknown risks, uncertainties and other factors beyond the Company's ability to predict or control that may cause the actual results, events or developments to be materially different from any future results, events or developments expressed or implied by such forward-looking statements, and as such, readers are cautioned not to place undue reliance on forward-looking statements. Such risk factors include, among others, the Company's future product revenues, stage of development, additional capital requirements, risks associated with the completion and timing of clinical trials and obtaining regulatory approval to market the Company's products, the ability to protect its intellectual property, dependence upon collaborative partners, changes in government regulation or regulatory approval processes, and rapid technological change in the industry.
Such statements are based on a number of assumptions which may prove to be incorrect, including, but not limited to, assumptions about: general business and economic conditions; the impact of changes in Canadian-US dollar and other foreign exchange rates on the Company's revenues, costs and results; the timing of the receipt of regulatory and governmental approvals for the Company's research and development projects; the availability of financing for the Company's commercial operations and/or research and development projects, or the availability of financing on reasonable terms; results of current and future clinical trials; the uncertainties associated with the acceptance and demand for new products and market competition. The foregoing list of important factors and assumptions is not exhaustive. The Company undertakes no obligation to update publicly or otherwise revise any forward-looking statements or the foregoing list of factors, other than as may be required by applicable legislation. Additional discussion regarding the risks and uncertainties relating to the Company and its business can be found in the Company's other filings with the applicable Canadian securities regulatory authorities or the US Securities and Exchange Commission, and in the "Risk Factors" section of its Form 20F for the year ended May 31, 2012.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
Contacts:
Medicure Inc.
Dawson Reimer
President & COO
888-435-2220
204-488-9823 (FAX)
info@medicure.com
www.medicure.com
Management is trying ad-nauseum to raise the share price prior to the 15 for 1 share shellacking that current investors are going to absorb. Can't wait to see the bid/ask on this after the reverse split with the anemic volume we are undergoing...
MCUJ - Medicure Announces Intention to Seek Expanded Aggrastat Label
Medicure Inc. (QB) (USOTC:MCUJ)
Today : Tuesday 2 October 2012
Medicure Inc. ("Medicure" or the "Company") (TSX VENTURE:MPH)(PINKSHEETS:MCUJ), is pleased to announce its intention to file a supplemental new drug application (sNDA) for the high dose bolus (HDB) dosing regimen of AGGRASTAT® (tirofiban HCl). The Company also announces that the United States Food and Drug Administration (FDA) has granted the Company's request for a waiver of the US $979,400 application fee for the planned sNDA.
The planned sNDA submission is to request the addition of the AGGRASTAT HDB regimen (an initial bolus of 25 mcg/kg and then continued at 0.15 mcg/kg/min) to the approved prescribing information for AGGRASTAT. The rationale for the AGGRASTAT HDB regimen is to attain therapeutic platelet inhibition more rapidly than the currently approved dosing regimen (an initial rate of 0.4 mcg/kg/min for 30 minutes and then continued at 0.1 mcg/kg/min).
Bolus dosing is the most common approach to administering a glycoprotein IIb/IIIa inhibitor (GPI)(1). Since AGGRASTAT is the only GPI that does not have an FDA approved bolus dosing regimen, the addition of the HDB regimen would better position the product to compete in the contemporary market.
In communication with the Company, the FDA's Division of Cardiovascular and Renal Drug Products has indicated its willingness to review and evaluate this label change request based substantially on published studies involving the AGGRASTAT HDB regimen. The efficacy and safety of the HDB regimen has been evaluated in more than 20 clinical studies involving over 7,000 patients and is currently recommended by the ACCF/AHA treatment guidelines (2), (3), (i).
In September 2010 the AGGRASTAT HDB regimen was approved in the European Union. AGGRASTAT is the most used GPI outside of the United States(1). The Company's subsidiary, Medicure International, Inc. (Barbados) holds the rights to AGGRASTAT in the United States and its territories.
The Company anticipates filing the sNDA before the end of calendar 2012, which will result in a Prescription Drug User Fee Act (PDUFA) action date for the AGGRASATAT HDB sNDA in the second half of 2013. Under PDUFA, the FDA aims to complete its review within ten months from the receipt of an sNDA submission.
The United States Federal Food, Drug and Cosmetic Act (the Act) stipulates that sponsors requesting a label change for a prescription drug must pay a user fee prior to consideration of the sNDA. As of October 2012, the amount of the user fee for the sNDA submission is US $979,400. The Company applied for and was successful in receiving a waiver of this application fee under the barrier-to-innovation provision of the Act, therefore it is not required to pay any user fee for applications submitted within the next 12 months.
About Aggrastat
AGGRASTAT (tirofiban HCl), in combination with heparin, is indicated for the treatment of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy. In this setting, AGGRASTAT has been shown to decrease the rate of a combined endpoint of death, new myocardial infarction or refractory ischemia/repeat cardiac procedure. AGGRASTAT has been studied in a setting that included aspirin and heparin.
Bleeding is the most common complication encountered during therapy with AGGRASTAT. Administration of AGGRASTAT is associated with an increase in bleeding events classified as both major and minor bleeding events by criteria developed by the Thrombolysis in Myocardial Infarction Study group (TIMI). Most major bleeding associated with AGGRASTAT occurs at the arterial access site for cardiac catheterization. Fatal bleedings have been reported. AGGRASTAT should be used with caution in patients with platelet count less than 150,000/mm3, in patients with hemorrhagic retinopathy, and in chronic hemodialysis patients. Because AGGRASTAT inhibits platelet aggregation, caution should be employed when it is used with other drugs that affect hemostasis. The safety of AGGRASTAT when used in combination with thrombolytic agents has not been established. During therapy with AGGRASTAT, patients should be monitored for potential bleeding. When bleeding cannot be controlled with pressure, infusion of AGGRASTAT and heparin should be discontinued.
AGGRASTAT is a parenteral non-peptide, reversible GP IIb/IIIa receptor antagonist that is marketed in the United States by Medicure Pharma, Inc. Please see the AGGRASTAT Prescribing Information for approved indications, dosage regimens and safety related information.
The AGGRASTAT HDB dosing regimen discussed in this press release has not been approved by the FDA.
About Medicure Inc.
Medicure is a specialty pharmaceutical company focused on the development and commercialization of novel small molecule therapeutics. The primary focus of the Company and its subsidiaries is the marketing and distribution of AGGRASTAT (tirofiban HCl) for acute coronary syndromes in the United States, where it is sold through the Company's US subsidiary, Medicure Pharma, Inc. For more information on Medicure please visit www.medicure.com.
To be added to Medicure's e-mail list, please visit: http://www.medicure.com/news.html
Forward Looking Information: Statements contained in this press release that are not statements of historical fact, including, without limitation, statements containing the words "believes", "may", "plans", "will", "estimates", "continues", "anticipates", "intends", "expects" and similar expressions, may constitute "forward-looking information" within the meaning of applicable Canadian and U.S. federal securities laws (such forward-looking information and forward-looking statements are hereinafter collectively referred to as "forward-looking statements"). Forward-looking statements, including but not limited to those about the Company's ability to file an supplemental New Drug Application to obtain approval of the AGGRASTAT high dose bolus dosing regimen, the timing of the Company's sNDA submission, and the timeliness and approvability of such an application by the United States Food and Drug Administration, are based on the current assumptions, estimates, analysis and opinions of management of the Company made in light of its experience and its perception of trends, current conditions and expected developments, as well as other factors which the Company believes to be relevant and reasonable in the circumstances. Inherent in forward-looking statements are known and unknown risks, uncertainties and other factors beyond the Company's ability to predict or control that may cause the actual results, events or developments to be materially different from any future results, events or developments expressed or implied by such forward-looking statements, and as such, readers are cautioned not to place undue reliance on forward-looking statements. Such risk factors include, among others, the Company's future product revenues, stage of development, additional capital requirements, risks associated with the completion and timing of clinical trials and obtaining regulatory approval to market the Company's products, the ability to protect its intellectual property, dependence upon collaborative partners, changes in government regulation or regulatory approval processes, and rapid technological change in the industry.
Such statements are based on a number of assumptions which may prove to be incorrect, including, but not limited to, assumptions about: general business and economic conditions; the impact of changes in Canadian-US dollar and other foreign exchange rates on the Company's revenues, costs and results; the timing of the receipt of regulatory and governmental approvals for the Company's research and development projects; the availability of financing for the Company's commercial operations and/or research and development projects, or the availability of financing on reasonable terms; results of current and future clinical trials; the uncertainties associated with the acceptance and demand for new products and market competition. The foregoing list of important factors and assumptions is not exhaustive. The Company undertakes no obligation to update publicly or otherwise revise any forward-looking statements or the foregoing list of factors, other than as may be required by applicable legislation. Additional discussion regarding the risks and uncertainties relating to the Company and its business can be found in the Company's other filings with the applicable Canadian securities regulatory authorities or the US Securities and Exchange Commission, and in the "Risk Factors" section of its Form 20F for the year ended May 31, 2012.
(1) IMS Health.
(2) 2012 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Unstable Angina/ Non-ST-Elevation Myocardial Infarction (Updating the 2007 Guideline and Replacing the 2011 Focused Update). Jneid H et al. J Am Coll Cardiol 2012;60:645-81.
(3) 2011 ACCF/AHA/SCAI Guideline for Percutaenous Coronary Intervention. Levine GN, et al. Circulation 2012;124:e574-e651.
(i) The HDB dosing regimen discussed in the ACCF/AHA treatment guidelines has not been approved by the FDA.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
Contacts:
Medicure Inc.
Dawson Reimer
President & COO
888-435-2220
204-488-9823 (FAX)
info@medicure.com
www.medicure.com
MCUJ - Medicure Announces Development of Novel AGGRASTAT Formulation
Medicure Inc. (QB) (USOTC:MCUJ)
Today : Wednesday 26 September 2012
Medicure Inc. ("Medicure" or the "Company") (TSX VENTURE:MPH)(PINKSHEETS:MCUJ), is pleased to announce the development of a transdermal delivery formulation of its lead drug, AGGRASTAT® (tirofiban HCl).
The ability to administer a drug transdermally (i.e. through the skin) provides a convenient way to deliver a stable, therapeutic level of medication to the patient. AGGRASTAT and other antiplatelet drugs of its class (known as glycoprotein IIb/IIIa inhibitors or GPIs) are currently only administered by intravenous infusion. In vivo proof of principle for the transdermal delivery of therapeutic levels of AGGRASTAT's active ingredient, tirofiban, was recently established in animal studies conducted in collaboration with 4P Therapeutics, Inc. (Alpharetta, GA). 4P Therapeutics, a world leader in the research and development of novel transdermal products, has entered into an agreement with the Company's subsidiary, Medicure International, Inc., to further develop transdermal tirofiban.
The Company's initial target use for transdermal tirofiban is the treatment of acute coronary syndromes for which the drug is already approved by the United States Food and Drug Administration and currently receives a Class 1 recommendation from the nationally recognized ACCF/AHA treatment guidelines.(1)The delivery of tirofiban by a novel, transdermal method has potential to provide significant advantages over the current treatments used in this setting, including the potential for increased use prior to hospitalization.
"The introduction of a transdermal glycoprotein IIb/IIIa inhibitor would have a significant impact on the management of several cardiovascular conditions," stated Dr. David Lee, Director of the Cardiac Catheterization and Coronary Intervention Laboratories, Stanford University Medical Center. "This innovation would not only further enhance the ease-of-use and convenience associated with this class of drugs, but may also facilitate earlier, prehospital administration as well as a number of other new applications."
The global market for antiplatelet drugs is over $8 billion per year, of which AGGRASTAT and the other intravenous GPIs make up approximately $500 million per year. The largest share of the market is held by oral antiplatelet drugs, such as clopidogrel (Plavix(TM)) and ASA (Aspirin(TM)), which by virtue of their route of administration can be used in a variety of settings where intravenous administration is not feasible. While these treatments will continue to serve an important role in cardiovascular therapy, the use of oral antiplatelet drugs for some patients and conditions is limited by a number of drawbacks including inter-individual variability, resistance, drug-drug interactions and delays in reversal of effect. Transdermal tirofiban has the potential to avoid these problems and to carry the unique benefits of a GPI, including the ability to dissolve and to directly prevent formation of platelet aggregates (blood clots).
If successful in advancing transdermal tirofiban, the Company may also look to expand the development and application of this product to other indications that aren't satisfactorily treated with current antiplatelet drugs. One such potential application may be in providing platelet inhibition to patients who have been required to stop use of oral platelet inhibitors prior to surgery (commonly referred to as "bridging therapy"). Tirofiban's properties as a broadly effective, rapidly reversible, small-molecule platelet inhibitor, combined with a simple means of delivering the drug outside of a hospital setting, make this a promising opportunity.
"The development of transdermal tirofiban is a component of our AGGRASTAT life cycle management strategy that builds upon our traditional expertise in cardiovascular drug development," added Dawson Reimer, President and Chief Operating Officer of Medicure. "A product that delivers tirofiban non-invasively through the skin may create value first in the same settings where the drug is currently approved and then, with further investment, in other applications. Patent and regulatory protection for transdermal tirofiban also provides opportunity for the Company to realize value both in and outside of the U.S. market."
The Company's subsidiary, Medicure International, Inc., holds international patent applications related to transdermal tirofiban.
"Based on the data generated to date, I have reason to believe that our team will be able to develop a convenient, efficient way to transdermally deliver therapeutic levels of this proven and well established intravenous drug," stated Steve Damon, Chief Executive Officer, 4P Therapeutics. "The fact that big pharma companies have spent hundreds of millions of dollars on attempts to introduce a non-intravenous, oral delivery form of this type of drug should serve as a testament to the market potential for this product and, most importantly, to the potential clinical benefit for patients."
About Aggrastat
AGGRASTAT (tirofiban HCl), in combination with heparin, is indicated for the treatment of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy. In this setting, AGGRASTAT has been shown to decrease the rate of a combined endpoint of death, new myocardial infarction or refractory ischemia/repeat cardiac procedure. AGGRASTAT has been studied in a setting that included aspirin and heparin.
Bleeding is the most common complication encountered during therapy with AGGRASTAT. Administration of AGGRASTAT is associated with an increase in bleeding events classified as both major and minor bleeding events by criteria developed by the Thrombolysis in Myocardial Infarction Study group (TIMI). Most major bleeding associated with AGGRASTAT occurs at the arterial access site for cardiac catheterization. Fatal bleedings have been reported. AGGRASTAT should be used with caution in patients with platelet count less than 150,000/mm3, in patients with hemorrhagic retinopathy, and in chronic hemodialysis patients. Because AGGRASTAT inhibits platelet aggregation, caution should be employed when it is used with other drugs that affect hemostasis. The safety of AGGRASTAT when used in combination with thrombolytic agents has not been established. During therapy with AGGRASTAT, patients should be monitored for potential bleeding. When bleeding cannot be controlled with pressure, infusion of AGGRASTAT and heparin should be discontinued.
AGGRASTAT is a parenteral non-peptide, reversible GP IIb/IIIa receptor antagonist that is marketed in the United States by Medicure Pharma, Inc. Please see the AGGRASTAT Prescribing Information for approved indications, dosage regimens and safety related information.
The transdermal AGGRASTAT delivery and the potential applications of such a product as discussed in this press release have yet to be demonstrated as safe and effective in humans and have not been approved by the FDA.
About Medicure Inc.
Medicure is a specialty pharmaceutical company focused on the development and commercialization of novel small molecule therapeutics. The primary focus of the Company and its subsidiaries is the marketing and distribution of AGGRASTAT (tirofiban HCl) for acute coronary syndromes in the United States, where it is sold through the Company's US subsidiary, Medicure Pharma, Inc. For more information on Medicure please visit www.medicure.com.
About 4P Therapeutics, Inc.
4P Therapeutics is a private company focused on the research and development of novel drug delivery technologies and novel drug delivery based therapeutics. The company has capabilities for developing pharmaceutical products from pre-clinical testing to clinical manufacturing and early stage clinical development (Phase I/II). A key company focus and area of expertise is in the development of transdermal products from currently injected compounds, including proteins, peptides, macromolecules and biologics. Transdermal delivery of commercially available drugs or biologics that are typically delivered via injection has the potential to improve safety, efficacy and therapeutic outcomes associated with these treatments. For more information on 4P Therapeutics please visit www.4ptherapeutics.com.
To be added to Medicure's e-mail list, please visit: http://medicure.com/newsreleases.html.
Forward Looking Information: Statements contained in this press release that are not statements of historical fact, including, without limitation, statements containing the words "believes", "may", "plans", "will", "estimates", "continues", "anticipates", "intends", "expects" and similar expressions, may constitute "forward-looking information" within the meaning of applicable Canadian and U.S. federal securities laws (such forward-looking information and forward-looking statements are hereinafter collectively referred to as "forward-looking statements"). Forward-looking statements, including those about the ability of the Company and 4P Therapeutics to develop and successfully advance a transdermal formulation of tirofiban, are based on the current assumptions, estimates, analysis and opinions of management of the Company made in light of its experience and its perception of trends, current conditions and expected developments, as well as other factors which the Company believes to be relevant and reasonable in the circumstances. Inherent in forward-looking statements are known and unknown risks, uncertainties and other factors beyond the Company's ability to predict or control that may cause the actual results, events or developments to be materially different from any future results, events or developments expressed or implied by such forward-looking statements, and as such, readers are cautioned not to place undue reliance on forward-looking statements.
Such risk factors include, among others, the Company's future product revenues, stage of development, additional capital requirements, risks associated with the completion and timing of clinical trials and obtaining regulatory approval to market the Company's products, the ability to protect its intellectual property, dependence upon collaborative partners, changes in government regulation or regulatory approval processes, and rapid technological change in the industry. Such statements are based on a number of assumptions which may prove to be incorrect, including, but not limited to, assumptions about: general business and economic conditions; the impact of changes in Canadian-US dollar and other foreign exchange rates on the Company's revenues, costs and results; the timing of the receipt of regulatory and governmental approvals for the Company's research and development projects; the availability of financing for the Company's commercial operations and/or research and development projects, or the availability of financing on reasonable terms; results of current and future clinical trials; the uncertainties associated with the acceptance and demand for new products and market competition. The foregoing list of important factors and assumptions is not exhaustive. The Company undertakes no obligation to update publicly or otherwise revise any forward-looking statements or the foregoing list of factors, other than as may be required by applicable legislation. Additional discussion regarding the risks and uncertainties relating to the Company and its business can be found in the Company's other filings with the applicable Canadian securities regulatory authorities or the US Securities and Exchange Commission, and in the "Risk Factors" section of its Form 20F for the year ended May 31, 2012.
(1) 2012 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Unstable Angina/ Non-ST-Elevation Myocardial Infarction (Updating the 2007 Guideline and Replacing the 2011 Focused Update). Jneid H, Anderson, JL, Wright RS, Adams CD et al. J Am Coll Cardiol 2012;60:645-81.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
Contacts:
Medicure Inc.
Dawson Reimer
President & COO
888-435-2220
204-488-9823 (FAX)
info@medicure.com
www.medicure.com
MCUJ - Medicure Announces Proposed Fifteen to One Share Consolidation
Medicure Inc. (QB) (USOTC:MCUJ)
Today : Friday 21 September 2012
Medicure Inc. ("Medicure" or the "Company") (TSX VENTURE:MPH)(PINKSHEETS:MCUJ), a specialty pharmaceutical company, announced today that its Board of Directors have approved a consolidation of the Company's common shares ("Common Shares") on the basis of fifteen pre-consolidation Common Shares for each one post-consolidation Common Share, subject to the approval of the TSX Venture Exchange.
A special resolution was passed at the Company's Annual and Special Meeting held on November 22, 2011, to give the Board of Directors of the Company the discretion to approve a consolidation of the Company's Common Shares on the basis of a range of four pre-consolidation Common Shares for each one post-consolidation Common Share to fifteen pre-consolidation Common Shares for each one post-consolidation Common Share. As at September 21, 2012, the Company had 182,947,595 Common Shares issued and outstanding. Following the consolidation, it is expected that the Company will have approximately 12,196,506 Common Shares issued and outstanding. The numbers of Common Shares reserved for issuance under the Company's Stock Option Plan and the number of Common Shares that may be purchased upon exercise of warrants will be reduced proportionately. No fractional shares will be issued, but instead will be rounded to the nearest whole common share. Once TSX Venture Exchange approval is obtained, the Company will issue a further news release and shareholders will receive a letter of transmittal from Computershare, the Company's exchange agent. The Company's name and trading symbol will not change as a result of the consolidation.
Further details with respect to the consolidation are contained in the Company's Management Proxy Circular dated October 14, 2011, a copy of which is available on SEDAR at www.sedar.com.
About Medicure Inc.
Medicure is a specialty pharmaceutical company focused on the development and commercialization of novel small molecule therapeutics. The primary focus of the Company and its subsidiaries is the marketing and distribution of AGGRASTAT® (tirofiban HCl) for acute coronary syndromes in the United States, where it is sold through the Company's US subsidiary, Medicure Pharma, Inc. For more information on Medicure please visit www.medicure.com.
To be added to Medicure's e-mail list, please visit:
http://www.medicure.com/news.html
Forward Looking Information
Statements contained in this press release that are not statements of historical fact, including, without limitation, statements containing the words "believes", "may", "plans", "will", "estimates", "continues", "anticipates", "intends", "expects" and similar expressions, may constitute "forward-looking information" within the meaning of applicable Canadian and U.S. federal securities laws (such forward-looking information and forward-looking statements are hereinafter collectively referred to as "forward-looking statements"). Forward-looking statements are based on the current assumptions, estimates, analysis and opinions of management of the Company made in light of its experience and its perception of trends, current conditions and expected developments, as well as other factors which the Company believes to be relevant and reasonable in the circumstances. Inherent in forward-looking statements are known and unknown risks, uncertainties and other factors beyond the Company's ability to predict or control that may cause the actual results, events or developments to be materially different from any future results, events or developments expressed or implied by such forward-looking statements, and as such, readers are cautioned not to place undue reliance on forward-looking statements.
Such risk factors include, among others, the Company's future product revenues, stage of development, additional capital requirements, risks associated with the completion and timing of clinical trials and obtaining regulatory approval to market the Company's products, the ability to protect its intellectual property, dependence upon collaborative partners, changes in government regulation or regulatory approval processes, and rapid technological change in the industry. Such statements are based on a number of assumptions which may prove to be incorrect, including, but not limited to, assumptions about: general business and economic conditions; the impact of changes in Canadian-US dollar and other foreign exchange rates on the Company's revenues, costs and results; the timing of the receipt of regulatory and governmental approvals for the Company's research and development projects; the availability of financing for the Company's commercial operations and/or research and development projects, or the availability of financing on reasonable terms; results of current and future clinical trials; the uncertainties associated with the acceptance and demand for new products and market competition. The foregoing list of important factors and assumptions is not exhaustive. The Company undertakes no obligation to update publicly or otherwise revise any forward-looking statements or the foregoing list of factors, other than as may be required by applicable legislation. Additional discussion regarding the risks and uncertainties relating to the Company and its business can be found in the Company's other filings with the applicable Canadian securities regulatory authorities or the US Securities and Exchange Commission, and in the "Risk Factors" section of its Form 20F for the year ended May 31, 2012.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
Contacts:
Medicure Inc.
Dawson Reimer
President & COO
888-435-2220
204-488-9823 (FAX)
info@medicure.com
www.medicure.com
MCUJ - Medicure Reports Financial Results for Fiscal 2012
Medicure Inc. (QB) (USOTC:MCUJ)
Today : Wednesday 19 September 2012
Medicure Inc. ("Medicure" or the "Company") (TSX VENTURE:MPH)(PINKSHEETS:MCUJ), a specialty pharmaceutical company, today reported its results from operations for the fiscal year ended May 31, 2012.
2012 Highlights:
-- Recorded $4.8 million of revenue during the year ended May 31, 2012
compared to $3.6 million for the previous fiscal year;
-- Net revenue from the sale of AGGRASTAT® finished product decreased
compared to the previous fiscal year to $2.9 million from $3.6 million;
-- Net income for the year ended May 31, 2012 was $23.3 million, compared
to a net loss of $1.6 million for the previous fiscal year. The net
income in the current fiscal year primarily relates to a $23.9 million
non-cash gain relating to the settlement of the Company's long-term
debt.
Financial Results
Revenues for the year ended May 31, 2012 totalled $4.8 million compared to $3.6 million for the year ended May 31, 2011. Net revenue from the sale of AGGRASTAT finished product for the three months ended May 31, 2012 was $371,000 compared to $774,000 for the same quarter last year. Net revenue from the sale of finished AGGRASTAT product for the year ended May 31, 2012 decreased by $0.7 million or 21% to $2.9 million from $3.6 million for the previous fiscal year. The decrease in revenues compared to the previous fiscal periods corresponds with an overall decline in use of injectable antiplatelet drugs. It is also attributable to increases in discounts to new customers and fluctuations in foreign exchange rates.
Net loss for the quarter was $1.0 million or $0.01 per share, compared to a net loss of $1.9 million or $0.01 per share in the fourth quarter a year ago. Net income for the year ended May 31, 2012 was $23.4 million or $0.13 per share, compared to a net loss of $1.6 million or $0.01 per share for the previous fiscal year, primarily due to a $23.9 million non-cash gain relating to the settlement of the Company's long-term debt in the first quarter of fiscal 2012.
At May 31, 2012, the Company had cash totalling $1,124,345 compared to $750,184 as of May 31, 2011. Cash flows from operating activities for the year ended May 31, 2012 were $417,289, compared to $430,270 for the year ended May 31, 2011.
Product Developments
The ongoing focus of the Company and its primary asset of interest is AGGRASTAT. In parallel with its ongoing commitment to support and grow sales of the product, the Company is developing and implementing a new regulatory, brand and life cycle management strategy for AGGRASTAT. The objective of this strategy is to expand AGGRASTAT's share of the US$330 million (US sales, 2012) glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitor market and to advance a contemporary treatment approach that has potential to increase the number of patients for whom this treatment can be considered. GP llb/lla inhibitors are injectable antiplatelet drugs used to treat acute coronary syndromes and related conditions.
On May 10, 2012, the Company announced the commencement of enrollment in SAVI-PCI ("Shortened Aggrastat Versus Integrilin in Percutaneous Coronary Intervention") a prospective, multicenter, randomized clinical trial that is a part of the Company's overall product strategy for AGGRASTAT.
The SAVI-PCI study will enroll approximately 600 patients undergoing percutaneous coronary intervention (PCI) at sites across the United States. The study is designed to evaluate whether patients receiving the investigational, HDB regimen of AGGRASTAT (25 mcg/kg bolus over 3 minutes) followed by a shortened, 1 to 2 hour infusion of 0.15 mcg/kg/min will have outcomes that are similar, or "non-inferior," to patients receiving a 12 to 18 hour infusion of Integrilin® (eptifibatide) (Merck & Co., Inc.) at its FDA approved dosing regimen. The primary objective of SAVI-PCI is to demonstrate AGGRASTAT is non-inferior to Integrilin with respect to the composite endpoint of death, PCI-related myocardial infarction, urgent target vessel revascularization, or major bleeding within 48 hours following PCI or hospital discharge. The secondary objectives of this study include the assessment of safety as measured by the incidence of major bleeding.
The Company also maintains a modest investment in other research and development activities, including the ongoing Phase II clinical trial of TARDOXAL(TM) for the treatment of Tardive Dyskinesia.
The Company's ability to continue in operation for the foreseeable future remains dependent upon the effective execution of its business development and strategic plans.
About Financial Statements and Transition to IFRS
In February 2008, the Canadian Accounting Standards Board (AcSB) confirmed that the use of International Financial Reporting Standards (IFRS) would be required for Canadian publicly accountable enterprises for interim and annual financial statements effective for fiscal years beginning on or after January 1, 2011. The Company implemented these standards on June 1, 2011. The consolidated financial statements for the year ended May 31, 2012 are prepared under IFRS. Further information on this transition, comparisons to previous financial statements and the preparation of the financial statements are described in the notes of the consolidated financial statements.
All amounts referenced herein are in Canadian dollars unless otherwise noted.
About AGGRASTAT
AGGRASTAT (tirofiban HCl), in combination with heparin, is indicated for the treatment of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy. In this setting, AGGRASTAT has been shown to decrease the rate of a combined endpoint of death, new myocardial infarction or refractory ischemia/repeat cardiac procedure. AGGRASTAT has been studied in a setting that included aspirin and heparin.
Bleeding is the most common complication encountered during therapy with AGGRASTAT. Administration of AGGRASTAT is associated with an increase in bleeding events classified as both major and minor bleeding events by criteria developed by the Thrombolysis in Myocardial Infarction Study group (TIMI). Most major bleeding associated with AGGRASTAT occurs at the arterial access site for cardiac catheterization. Fatal bleedings have been reported. AGGRASTAT should be used with caution in patients with platelet count less than 150,000/mm3, in patients with hemorrhagic retinopathy, and in chronic hemodialysis patients. Because AGGRASTAT inhibits platelet aggregation, caution should be employed when it is used with other drugs that affect hemostasis. The safety of AGGRASTAT when used in combination with thrombolytic agents has not been established. During therapy with AGGRASTAT, patients should be monitored for potential bleeding. When bleeding cannot be controlled with pressure, infusion of AGGRASTAT and heparin should be discontinued.
AGGRASTAT is a parenteral non-peptide, reversible GP IIb/IIIa receptor antagonist that is marketed in the United States by Medicure Pharma, Inc. Please see the AGGRASTAT Prescribing Information for approved indications, dosage regimens and safety related information. The AGGRASTAT dosing regimen and the treatment setting studied in the SAVI-PCI study have not been approved by the FDA.
About Medicure Inc.
Medicure is a specialty pharmaceutical company focused on the development and commercialization of novel small molecule therapeutics. The primary focus of the Company and its subsidiaries is the marketing and distribution of AGGRASTAT (tirofiban HCl) for acute coronary syndromes in the United States, where it is sold through the Company's US subsidiary, Medicure Pharma, Inc. For more information on Medicure please visit www.medicure.com.
To be added to Medicure's e-mail list, please visit: http://medicure.com/news.html.
Forward Looking Information Statements contained in this press release that are not statements of historical fact, including, without limitation, statements containing the words "believes", "may", "plans", "will", "estimates", "continues", "anticipates", "intends", "expects" and similar expressions, may constitute "forward-looking information" within the meaning of applicable Canadian and U.S. federal securities laws (such forward-looking information and forward-looking statements are hereinafter collectively referred to as "forward-looking statements"). Forward-looking statements are based on the current assumptions, estimates, analysis and opinions of management of the Company made in light of its experience and its perception of trends, current conditions and expected developments, as well as other factors which the Company believes to be relevant and reasonable in the circumstances. Inherent in forward-looking statements are known and unknown risks, uncertainties and other factors beyond the Company's ability to predict or control that may cause the actual results, events or developments to be materially different from any future results, events or developments expressed or implied by such forward-looking statements, and as such, readers are cautioned not to place undue reliance on forward-looking statements.
Such risk factors include, among others, the Company's future product revenues, stage of development, additional capital requirements, risks associated with the completion and timing of clinical trials and obtaining regulatory approval to market the Company's products, the ability to protect its intellectual property, dependence upon collaborative partners, changes in government regulation or regulatory approval processes, and rapid technological change in the industry. Such statements are based on a number of assumptions which may prove to be incorrect, including, but not limited to, assumptions about: general business and economic conditions; the impact of changes in Canadian-US dollar and other foreign exchange rates on the Company's revenues, costs and results; the timing of the receipt of regulatory and governmental approvals for the Company's research and development projects; the availability of financing for the Company's commercial operations and/or research and development projects, or the availability of financing on reasonable terms; results of current and future clinical trials; the uncertainties associated with the acceptance and demand for new products and market competition. The foregoing list of important factors and assumptions is not exhaustive. The Company undertakes no obligation to update publicly or otherwise revise any forward-looking statements or the foregoing list of factors, other than as may be required by applicable legislation. Additional discussion regarding the risks and uncertainties relating to the Company and its business can be found in the Company's other filings with the applicable Canadian securities regulatory authorities or the US Securities and Exchange Commission, and in the "Risk Factors" section of its Form 20F for the year ended May 31, 2012.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
Contacts:
Medicure Inc.
Dawson Reimer
President & COO
888-435-2220
204-488-9823 (FAX)
info@medicure.com
www.medicure.com
Medicure never released an annual report. Checked the SEC filings...past years they have done so around this time.
MCUJ - He has confidence in his products.
Yet more insider buys since I last posted, Mr. Friesen bought another 300,000 shares on the 20th (on the TSX), bringing the total he's bought this month to just over 800,000. Looks like he's on his way to buy over a million if this keeps up!
http://www.canadianinsider.com/node/7?menu_tickersearch=Medicure+Inc.+|+MPH
STE, what do you make of all this buying on the open market, by none other than the company CEO?
Good luck to all,
Sunpillar
MCUJ - No problems with TDA, ETrade, or Vanguard to buy or put sell orders in for Medicure.
I cannot sell this stock!! I have 2 brokerage accounts and one wants to charge me an exhorbitant fee for selling it ($500+)...the other refuses to sell it.
Has anyone sold shares in mcuj at a reasonable commission, and if so, what brokerage?...thank you,
MCUJ - Watching closely. Volume has been interesting as of late.
I just noticed that there has been a sudden rush of insider buying, specifically by Mr. Friesen. Between August 10 and August 15, approximately 500,000 shares were purchased by him on the open market (on the TSX exchange)..
Here is a link to the trades:
http://canadianinsider.com/node/7?menu_tickersearch=Medicure+Inc.+|+MPH
I don't know if it means anything or not, but I cannot think it is a bad thing either.
Good luck!
Sunpillar
MCUJ - I have noticed the same. News and this goes!
I notice there has been some quiet but consistent accumulation here the past week or two.. the price has been constantly creeping-up a little almost every day.
I wonder if something might be brewing? Any thoughts out there? Otherwise it has been very quiet.
Cheers
Sunpillar.
MCUJ - Still on radar and watching. Clinical trial results will take time. Company needs to put a commercial development plan in place.
Green on low volume!
Followers
|
19
|
Posters
|
|
Posts (Today)
|
0
|
Posts (Total)
|
1313
|
Created
|
10/18/08
|
Type
|
Free
|
Moderators |
Volume | |
Day Range: | |
Bid Price | |
Ask Price | |
Last Trade Time: |