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Novavax underdelivers on its Covid vaccine promises https://www.cnbc.com/2022/02/08/novavax-underdelivers-on-its-covid-vaccine-promises.html?__source=iosappshare%7Ccom.apple.UIKit.activity.CopyToPasteboard
CHMP approves three new Opdivo indications with PD-L1 expression >=1%...
Opdivo monotherapy in adjuvant MIUC:
https://www.businesswire.com/news/home/20220223006231/en
Opdivo/Yervoy in first-line esophageal:
https://www.businesswire.com/news/home/20220224006058/en
Opdivo/chemo in first-line esophageal:
https://www.businesswire.com/news/home/20220224006066/en
Posted by Dew Diligence....
Dr. Duchene explained that usually all viruses mutate at a fairly constant rate, with most taking a year or more to develop a new variant.
"However, what we were seeing with the variants of SARS-CoV-2, particularly the variants of concern, is that they have undergone many more mutations than we would expect under the normal evolutionary pace of similar coronaviruses," Dr. Duchene said.
"The Delta variant, for example, emerged within just six weeks from its ancestral form."
https://phys.org/news/2022-02-rapid-emergence-sar
CDC says longer wait between Pfizer, Moderna doses may reduce myocarditis risk https://www.cnbc.com/2022/02/23/cdc-says-waiting-longer-between-pfizer-moderna-doses-may-reduce-myocarditis-risk.html?__source=iosappshare%7Ccom.apple.UIKit.activity.CopyToPasteboard
Moderna expects at least $19 billion in Covid vaccine sales in 2022
Moderna expects at least $19 billion in Covid vaccine sales in 2022
https://www.cnbc.com/2022/02/24/covid-moderna-mrna-q4-2021-earnings.html?__source=iosappshare%7Ccom.apple.UIKit.activity.Message
AND, THEY DON’T WORK!!
BUT FDA, CDC, BIDENHISTIME ADMINISTRATION SQUASH EFFICACIOUS THERAPEUTIC COMPANIES!!!
BUT NOT FOR LONG!!
We have already seen several countries begin to roll back Covid restrictions.
https://www.forbes.com/sites/carlieporterfield/2022/02/16/switzerland-drops-covid-restrictions--see-what-other-countries-have-already-rolled-back-pandemic-rules/?sh=454893b57de1
Not only is BA.2 spreading quickly, there is also a BA.3. ......
"We analyzed these three lineages' spike protein mutations in the online tool “SARS-CoV-2 (hCoV-19) Mutation Reports”9 (Figure 1A). We have analyzed almost all BA.1 (289,761 sequences), BA.2 (3,562 sequences), and BA.3 (39 sequences) sequences available in GISAID on January 12, 2022. This study revealed 37 mutations in the spike protein of BA.1, 31 mutations in BA.2, and 33 mutations in BA.3."
https://onlinelibrary.wiley.com/doi/10.1002/jmv.27601
Also, we have this: "FDA Reportedly Mulling Approving Second Covid Booster Shot"
https://newsfilter.io/latest/fda-approvals ..... Credit Cowtown Jay
There are seven types of coronavirus known to cause illness in humans:
229E (alpha coronavirus)
NL63 (alpha coronavirus)
OC43 (beta coronavirus)
HKU1 (beta coronavirus)
MERS-CoV
SARS-CoV
SARS-CoV-2
In the past two decades, some coronaviruses have evolved in animal species to the point where they can cause infections in humans. This is called a “spillover event.”
The human immune system is not familiar with these viruses, so they tend to cause serious illness and spread easily.
https://www.medicalnewstoday.com/articles/how-old-is-coronavirus#covid-19-origin
What is NOT A Dr. ; EVIL and his evil one percent of the one percenters planning on next now? Is he even telling us it’s coming??
Bill Gates says Covid risks have 'dramatically reduced' but another pandemic is coming https://www.cnbc.com/2022/02/18/bill-gates-covid-risks-have-reduced-but-another-pandemic-will-come.html?__source=iosappshare%7Ccom.apple.UIKit.activity.CopyToPasteboard
Coronavirus: As BA.2 subvariant of Omicron rises, lab studies point to signs of severity
https://www.msn.com/en-us/health/medical/coronavirus-as-ba-2-subvariant-of-omicron-rises-lab-studies-point-to-signs-of-severity/ar-AAU086M
https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html?fbclid=IwAR0pWh5dptsErY4xwOb_RaD1cGUbXqlrx3z9o6tHGfuHV6VX4eblmwlA08I
Resistant to monoclonal antibody treatments ....
The new study found that BA.2 can copy itself in cells more quickly than BA.1, the original version of Omicron. It's also more adept at causing cells to stick together. This allows the virus to create larger clumps of cells, called syncytia, than BA.1. That's concerning because these clumps then become factories for churning out more copies of the virus. Delta was also good at creating syncytia, which is thought to be one reason it was so destructive to the lungs.
When the researchers infected hamsters with BA.2 and BA.1, the animals infected with BA.2 got sicker and had worse lung function. In tissues samples, the lungs of BA.2-infected hamsters had more damage than those infected by BA.1.
How worried should we be about the new stealth Omicron? .
Similar to the original Omicron, BA.2 was capable of breaking through antibodies in the blood of people who'd been vaccinated against Covid-19. It was also resistant to the antibodies of people who'd been infected with Covid-19 early in the pandemic, including Alpha and Delta. And BA.2 was almost completely resistant to some monoclonal antibody treatments.
But there was a bright spot: Antibodies in the blood of people who'd recently had Omicron also seemed to have some protection against BA.2, especially if they'd also been vaccinated.
And that raises an important point, Fuller says. Even though BA.2 seems more contagious and pathogenic than Omicron, it may NOT wind up causing a more devastating wave of Covid-19 infections.
"One of the caveats that we have to think about as we get new variants that might seem more dangerous is the fact that there's two sides to the story," Fuller says.
The virus matters, she says, but as its would-be hosts, so do we.
"Our immune system is evolving as well. And so that's pushing back on things," she said.
Right now, she says, we're in a race against the virus, and the key question is, who's in the lead?
"What we will ultimately want is to have the host be ahead of the virus. In other words, our immunity, be a step ahead of the next variant that comes out, and I don't know that we're quite there yet," she said.
For that reason, Fuller says, she feels like it's not quite time for communities to lift mask mandates.
"Before this thing came out, we were about 10 feet away from the finish line," she said.
We subsequently discover that PD-L1+TANs induced by LSCC-derived GM-CSF potently impair CD8+ T-cells proliferation and cytokines production function, which are partially blocked by a PD-L1-neutralizing antibody. Clinical data further support GM-CSF as an unfavorable prognostic biomarker and reveal a potential association with inflammatory immune cell infiltration, in particular neutrophils.
Conclusion: Tumor-infiltrating PD-L1+ neutrophils induced by LSCC-derived GM-CSF suppress T cell proliferation and activation in the inflammatory microenvironment of LSCC and predict unfavorable prognosis. These TANs cripple antitumor T cell immunity and promote tumor progression. Our findings provide a basis for targeting PD-L1+TANs or GM-CSF as a new immunotherapeutic strategy for LSCC.
https://www.dovepress.com/tumor-infiltrating-pd-l1-neutrophils-induced-by-gm-csf-suppress-t-cell-peer-reviewed-fulltext-article-JIR
Moderna CEO says it’s ‘reasonable’ to think pandemic may be in its final stages https://www.cnbc.com/2022/02/16/moderna-ceo-says-its-reasonable-to-think-pandemic-may-be-in-its-final-stages.html?__source=iosappshare%7Ccom.apple.UIKit.activity.CopyToPasteboard
According to the World Health Organization, there were 15.47 million new cases reported in the last 7 days worldwide, and 73,162 deaths in the same period.
The reason we want to expand in Asia is the importance of that region. The fact that this virus is not going away ... this virus is going to stay with humans forever, like flu and we’d have to live with it.
Stephane Bancel .. CEO, MODERNA
Moderna, Pfizer stocks fall as Covid omicron wave subsides in U.S. https://www.cnbc.com/2022/02/14/moderna-pfizer-stocks-fall-as-omicron-covid-wave-subsides-in-us-.html?__source=iosappshare%7Ccom.apple.UIKit.activity.CopyToPasteboard
Omicron is fading, but nobody knows when the pandemic will finally end https://www.cnbc.com/2022/02/11/covid-no-one-knows-when-the-pandemic-will-end-after-omicron-upended-most-hope.html?__source=iosappshare%7Ccom.apple.UIKit.activity.CopyToPasteboard
https://nypost.com/2022/02/11/chicken-producers-warn-about-fast-spreading-bird-flu-spreading-across-us/
https://nypost.com/2021/11/15/bird-flu-spreads-in-europe-and-asia/
https://nypost.com/2021/12/27/bird-flu-outbreak-in-israel-kills-5000-cranes/
https://nypost.com/2021/11/15/bird-flu-spreads-in-europe-and-asia/
Out of 24 COVID months on record , Last month (1/22) clocks in as the 5th deadliest for the US."
https://stocktwits.com/symbol/HGEN
Even the new mAb the FDA authorized today is not authorized for hospitalized patients.
"Bebtelovimab is not authorized for patients who are hospitalized due to COVID-19 or require oxygen therapy due to COVID-19. Treatment with bebtelovimab has not been studied in patients hospitalized due to COVID-19."
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-new-monoclonal-antibody-treatment-covid-19-retains
EU investigates reports of menstrual disorders after mRNA Covid shots https://www.cnbc.com/2022/02/11/eu-investigates-reports-of-menstrual-disorders-after-mrna-covid-shots.html?__source=iosappshare%7Ccom.apple.UIKit.activity.CopyToPasteboard
Hospitalized Patients With Severe COVID-19 = Much BP Failure
Quote:
The NIH set up ACTIV-3 to test anti-SARS-CoV-2 monoclonal antibodies and other therapies in patients hospitalized with COVID-19. Brii Biosciences, Eli Lilly, GlaxoSmithKline and Novartis [and now Pfizer] are among the drug developers to contribute candidates to the study. All those candidates failed to move the needle in hospitalized patients with severe COVID-19, resulting in a persistent unmet need even as the broader pandemic armory has gone from strength to strength...
ACTIV-3 has been a rare graveyard for COVID-19 programs. The global vaccine race and push to create therapies for mild to moderate COVID-19 each featured multiple successes. But efforts to improve on Gilead Sciences' Veklury in hospitalized COVID-19 patients have floundered, potentially because by that point in the disease pathway elements other than the virus are at play. The NIH is still pushing ahead, though.
https://www.fiercebiotech.com/biotech/pfizer-a-rare-covid-19-setback-dumps-paxlovid-s-intravenous-sibling-to-leave-activ-3-future?utm_source=email&utm_medium=email&utm_campaign=LS-NL-FierceLifeSci&oly_enc_id=6011B0593889J3A
HGEN …
NEW PATENT APPLICATION: $HGEN Humanigen has filed a new U.S. patent application for "MATERIALS AND METHODS FOR TREATING CANCER."
https://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220220040229%22.PGNR.&OS=DN/20220040229&RS=DN/20220040229
Mental health damage from Covid could last a generation, professionals say https://www.cnbc.com/2022/02/10/covid-pandemic-mental-health-damage-could-last-a-generation.html?__source=iosappshare%7Ccom.apple.UIKit.activity.CopyToPasteboard
WHO says new omicron BA.2 subvariant will rise globally https://www.cnbc.com/2022/02/08/who-says-omicron-bapoint2-subvariant-will-rise-globally.html?__source=iosappshare%7Ccom.apple.UIKit.activity.CopyToPasteboard
The BA.2 omicron subvariant is more contagious, evades vaccine protections https://www.cnbc.com/2022/01/31/the-new-omicron-subvariant-is-more-contagious-but-vaccinated-people-are-less-likely-to-spread-it-study-finds.html?__source=iosappshare%7Ccom.apple.UIKit.activity.CopyToPasteboard
“ALWAYS” FOLLOW THE MONEY TRAIL!!!!!
IT GOES DOWN THE RABBIT HOLE ?? WHERE THE PROFITS GO ….. THERAPEUTICS THAT ARE EFFICACIOUS, GET SHUNNED AND CRUSED BY BIG PHARMA, FDA, CDC ET AL .....
Pfizer expects $54 billion in 2022 sales on Covid vaccine and treatment pill
https://www.cnbc.com/2022/02/08/covid-pfizer-pfe-earnings-q4-2021.html?__source=iosappshare%7Ccom.apple.UIKit.activity.CopyToPasteboard&fbclid=IwAR328rhIao5L1tZnYDSuS3MKDCntunvGfoeQ0Iors0jn_cI9iYu3lhbK5cw
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Assistants toddao kgoodrich |
This board is about medical news, medical and medicine advancements from pharmaceutical and biotech companies, as
well as Universities. Company explicit news is welcomed as
well as industry news. This is an information sharing board,
where the latest and newest medical related information can
be posted and disseminated. Enjoy your board...
Scientific and Medical dedicated Search engine:
http://www.scirus.com/srsapp/
http://science.howstuffworks.com/dna.htm
http://www.biologicdrugreport.com/
Naming convention for antibody suffixes:
-ximab = chimeric
-zumab = humanized
-(~z)umab = fully human
FDA and CDC sites:
FDA what's new site: http://www.fda.gov/ohrms/dockets/ac/acwhatsnew.htm
http://www.accessdata.fda.gov/scripts/cder/drugsatfda/
http://www.fda.gov/
http://www.fda.gov/cder/
http://news.google.com/news?q=FDA&hl=en&rls=DGUS,DGUS:2006-15,DGUS:en&um=1&ie=UTF-8&....
http://www.cdc.gov/
Researching sites:
http://clearstation.etrade.com/
http://www.breakouttrading.net/index2/index.php
http://moneycentral.msn.com/investor/home.asp
http://www.superstarinvestor.com/directory.html
http://www.nasdaq.com/
http://www.ddmachine.com/default.asp
http://new.stockwatch.com/
http://www.edgar-online.com/
Educational sites:
http://www.investopedia.com/
http://www.qwoter.com/college/
http://biotech-profits.org/
http://www.hardrightedge.com/wheel/tcrules1.htm
http://www.therapeuticsdaily.com/news/channel.cfm?channelID=28
http://www.medicalnewstoday.com/sections/genetics/
http://www.medicalnewstoday.com/sections/biology-biochemistry/
http://content.nejm.org/current.shtml
http://www.sciencedaily.com/
Some T/A sites:
http://www.americanbulls.com/
http://www.askresearch.com/
http://www.stockta.com/
http://www.stockconsultant.com./
http://www.investorshub.com/boards/read_msg.asp?message_id=297509
http://www.ttrader.com/dirttime.php
http://www.otcbb.com/asp/Info_Center.asp
http://bigcharts.marketwatch.com/
Find out if your stock is on the SHO List
http://www.buyins.net/tools/short_list.php?src=1,7,9
Understanding Level 11-http://www.hotstockmarket.com/forums/showthread.php?t=14938
OTCBB Biggest Gainers (%)http://www.stockhouse.com/mostactives/index.asp?type=winners&exchange=OTCBB
OTC Biggest Declinershttp://www.stockhouse.com/mostactives/index.asp?type=losers&exchange=OTCBB
OTC Biggest Volume Gainers http://www.stockhouse.com/mostactives/index.asp?type=mostactives&exchange=OTCBB
Technical Indicators http://stockcharts.com/school/doku.php?id=chart_school:technical_indicators
Screeners:
http://finviz.com/screener.ashx?v=111&f=cap_microover,geo_usa,sh_curvol_o100,sh_insttrans_o20,sh_price_o1,sh_short_u5,ta_rsi_ob70&ft=4&r=21 From Stock Seasonality Site.
http://www.marketscreen.com/c/pcquote/default.asp
http://moneycentral.msn.com/investor/finder/deluxestockscreen.aspx?query=Institutional+Ownership+Up+....
http://www.secform4.com/index.php
http://screen.morningstar.com/StockSelector.html
http://www.stockfetcher.com
http://investorideas.com/
http://www.wallstreettape.com/
http://findarticles.com/p/articles/mi_pwwi/is_200603/ai_n1610669
4
http://find.thestreet.com/cgi-bin/texis/tscsection/?k=Technology&sec=Technology&submenu=news....
Filings Sites:
http://www.pinksheets.com/
http://www.otcbb.com
http://www.gsionline.com/support/formtypes.html
http://www.coordinatedlegal.com/SecretaryOfState.html
http://www.searchsystems.net/list.php?nid=398
SEC FORM EXPLANATIONS
http://www.sec.gov/about/forms/secforms.htm
http://www.briefing.com/GeneralInfo/Features/LearningCenter/edu_SEC_Documents.htm
http://www.sec.gov/index.htm
To see how and about the SEC rules, regulations and cases involving stock manipulators.
SEC REALTIME FILINGS
http://www.nasdaq.com/asp/quotes_sec.asp?mode=&page=&symbol=QQQQ&symbol=&symbol=&....
http://home.businesswire.com/portal/site/home/index.jsp?front_door=true&headlineSearchConfigBO=v....
BOARD RULES:
The main objective for this moderated thread is to keep it free of posts which do not add value to the discussion of the stocks, the latest medical news, and information, while keeping the board balanced, clean, on-topic with due diligence kept up to date.
All posts here should stay focused on medical news and information.
Pro and con debate is encouraged as long as the opinions are kept on a mature level, with the omission of personal attacks,
violations of IHUB rules and basic civility.
Personal attacks, personal issues, political innuendo, spamming, duplicate posts of same subject matter, redundancy, obvious bashing, blatant pumping, irrelevant off topic subject matter, advertising, arguing, feeding and promoting bashers of other IHUB sites will be strictly prohibited.
Posts which the moderators feel violate these rules will be removed without question or debate.
If you are willing to cooperate and co~exist with other posters in this environment within the guidelines laid out, then welcome and have a great time posting and learning.
Please Note: Please add links to websites and information whenever they are available for accuracy and informational purposes.
Plus, I am not an MD, but rather a longtime biotech/pharma investor and former Quant analyst. So, if I can answer any questions relating to medical information, I will, and cede to any medical professionals whom are better equipped to answer those inquiries.
Thank you....PL1
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