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Medgenics (MDGN) RSS Feed

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Unlocking The Potential Of Gene Theraphy For Patients With Rare And Orphan Diseases....

About Medgenics, Inc.

Medgenics is developing TARGT™ (Transduced Autologous Restorative Gene Therapy), a proprietaryex vivo gene therapy platform for the sustained production and delivery of therapeutic proteins and peptides using a patient's own tissue, for the treatment of rare and orphan diseases. For more information, visit the Company's website at www.medgenics.com.

Our core strategy is based upon three fundamental strengths:

Strive for unparalleled understanding of the underlying science of rare diseases, from genotype to phenotype for each patient

  • Focused on developing “best-in-class” therapies that are life altering for our patients
    Capable of crossing scientific boundaries for new and better therapies where none existed before
    Centered around a capital-efficient platform that holds the potential to increase the speed of development
    Able to produce proteins, peptides, and other molecules
    Experienced and successful drug developers
    Demonstrated track record of guiding novel medicines to patients
    Driven to collaborate with our patients and advocacy groups to increase awareness and commitment to research, and improve access to therapies

  •  

TECHNOLOGY:


Transduced Autologus Restorative Gene Theraphy

 
































 
   
1. Harvest Micro-Organs from abdominal dermis using the proprietary DermaVac device

2. Transduce fibroblasts in Micro-Organs via ex vivo gene therapy to create TARGTEPO

3. Wash out HDAd vector, measure production and choose TARGTEPO for re-implantation
4. Implant TARGTEPO into patient where it produces endogenous EPO (eEPO)   
 

 

 

 

 

 

  • Closely mimics natural system, creating restorative treatment paradigm
    Improved durability in vivo
    Greater cell uptake
    Less immunogenicity
 
  • Ex vivo transduction eliminates patient exposure to viral vectors typically seen in gene therapy
    Reduced chance of developing neutralizing antibodies which can lead to reduced efficacy and anaphylactic reactions
    Ability to control dosing through the addition and removal of micro-organs as needed
    Implantation ensures compliance and better outcomes, and provides control of the product
 
  • Exogenous gene therapy on “tummy tuck” tissue is performed to testhuman protein expression in vitro
    Severe combined immunodeficient (SCID) mice provide predictive in vivomodel for protein expression and duration
    In vitro (human) and in vivo (SCID mouse) models provide 
    pre-clinical POC, for approximately $100K and less than 6 months
    Platform eliminates the need for large investment in manufacturing and scale up for clinical trial material

PIPELINE:



Visit MedGenics.com For Complete Details
 
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