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Last Post: 4/27/2022 9:51:06 AM - Followers: 12 - Board type: Free - Posts Today: 0

 

 

Immuron Reports Neutralizing activity Against SARS-CoV-2

Key Points:

  ? Immuron’s IMM-124E used to manufacture Travelan® and Protectyn® demonstrates antiviral activity against the COVID-19 virus in laboratory studies
  ? Immuron’s technology platform offers a potential new oral therapeutic approach to target SARS-CoV-2 in the GI Tract

 

Melbourne, Australia, July 21, 2020: Immuron Limited (ASX: IMC; NASDAQ: IMRN), an Australian biopharmaceutical company focused on developing and commercialising oral immunotherapeutics for the prevention and treatment of gut mediated pathogens, today is pleased to announce that IMM-124E used to manufacture the company’s flag ship commercially available and over-the-counter gastrointestinal and digestive health immune supplements Travelan® and Protectyn® has demonstrated neutralizing activity against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus that causes COVID-19.

The cytopathic effect inhibition cell-based assay was established and performed by 360 biolabs, a Melbourne based Contract Research Organization using the SARS-CoV-2 hCoV-19/Australia/VIC01/2020 virus obtained from Melbourne’s Peter Doherty Institute for Infection and Immunity. The in-vitro assessment of the neutralization of SARS-CoV-2 was performed on four production lots of product used to manufacture Travelan® and Protectyn®. The In-vitro susceptibility of the virus to IMM-124E was determined using the quantitative assay which measures virus replication in the presence of increasing concentrations of the product compared to replication in the absence of the product. The effective concentration of IMM-124E was reported as the concentration of the product at which virus replication is inhibited by 50 percent (EC50) or 90 percent (EC90).

All four production lots produced mean EC50 values of 40.5 to 91.9 ug/mL and inhibited viral replication at concentrations which there was no observed cell toxicity. The concentration of IMM-124E at which virus replication was inhibited by 90 percent (EC90) produced mean EC90 values ranging from 48.7 to 155.4 ug/mL for all four lots tested again at concentrations at which there was no observed cell toxicity. A commercially available high protein milk powder product was used as a placebo in the studies and produced EC50 values greater than the observed cellular cytotoxicity concentration of >4800 ug/mL. The control milk powder inhibited viral replication at doses >25,000 ug/mL and more importantly did not inhibit viral replication at doses which it was cytotoxic to cells.

Another major finding made during the study was that cell viability in the presence of IMM-124E was greatly enhanced when compared to placebo. IMM-124E improved cell viability by 180 to 260% relative to controls. These results indicate that IMM-124E at concentrations which inhibited SARS-CoV-2 replication improved cell viability.





US DoD Naval Medical Research Center Receives FDA Guidance on the clinical development plans for new oral therapeutic
July 20 2020 - 06:00AM
GlobeNewswire Inc.
Print

Immuron Limited (ASX: IMC; NASDAQ: IMRN), an Australian biopharmaceutical company focused on developing and commercializing oral immunotherapeutics for the prevention and treatment of gut mediated pathogens, today is pleased to announce that the Naval Medical Research Center (NMRC) has received written guidance from the U.S. Food and Drug administration (FDA) in relation to the clinical development pathway of a new investigational drug which the company is developing to treat moderate to severe campylobacteriosis and Enterotoxigenic Escherichia coli (ETEC) infections.

The Type B meeting with the FDA discussed the Chemistry, Manufacturing and Controls including the proposed release testing specifications of the product as well as the planned clinical studies evaluating the safety and efficacy of the product which the company is developing to prevent Campylobacter and ETEC mediated moderate to severe diarrhea.

The FDA were recently provided a Pre- Investigational New Drug (IND) package for the new Hyper-immune therapeutic which specifically targets Campylobacter jejuni capsule and Enterotoxigenic Escherichia coli (ETEC) colonization factor antigen 1. Following FDA review the agency provided a written response to the non-clinical questions posed in the briefing documentation as well as providing additional guidance and comments to support the planned IND submission.

“This is an important milestone in the development of any new drug for therapeutic evaluation. The information obtained from this review will assist in the development of the IND application and provides a clear roadmap forward for conducting the two planned clinical studies next year,” said Dr. Jerry Kanellos, CEO of Immuron Ltd. “The company is also please to inform shareholders that the manufacturing program is proceeding as planned. We have completed the second immunisation campaign and are on schedule to harvest the Hyper-immune colostrum in September this year which will be used to manufacture the drug product that will be used to treat moderate to severe campylobacteriosis and ETEC infections.”

This release has been authorised by the directors of Immuron Limited.

COMPANY CONTACT:
 
Dr Jerry Kanellos, Ph.D.
Chief Executive Officer
Ph: +61 (0)3 9824 5254
info@immuron.com

For more information visit: http://www.immuron.com

 

Primary Logo

www.immuron.com


Level 3, 62 Lygon Street,
Carlton South, Victoria
AUSTRALIA 3053

Phone: + 61 (0)3 9824 5254
Facsimile: + 61 (0)3 9822 7735




 

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IMRN News: Immuron US DoD Naval Medical Research Center Submits IND Application for New Campylobacter ETEC Therapeutic 05/11/2022 02:00:00 AM
IMRN News: Report of Foreign Issuer Pursuant to Rule 13a-16 or 15d-16 (6-k) 05/09/2022 03:35:02 AM
IMRN News: US Department of Defense Uniformed Services University Clinical Evaluation of Travelan™ 05/09/2022 02:00:00 AM
IMRN News: Immuron appoints Mr. Steven Lydeamore as Chief Executive Officer 05/05/2022 04:22:54 PM
IMRN News: Report of Foreign Issuer Pursuant to Rule 13a-16 or 15d-16 (6-k) 05/05/2022 02:48:33 AM
PostSubject
#164   Nice: Immuron Limited (the “Company”) published one announcement (the Tim 04/27/22 09:51:06 AM
#163   Thank you ! Man6677 03/21/22 03:42:36 PM
#162   btw Immuron warrants expire May 12th ..$10 gl... Pisd 03/21/22 03:40:59 PM
#161   I think IMRN is a good buy here Man6677 01/19/22 10:33:48 AM
#160   Maybe they learned a lesson?..develop Covid pill lol IMRN$.. Pisd 10/26/21 03:46:34 PM
#159   Sold when director left $4.70..buyer today $3.55 IMRN$... Pisd 10/26/21 03:29:16 PM
#158   Covid pill in development same as RVVTF$, gl... Pisd 08/11/21 02:54:27 PM
#155   Quiet here, good! ..waiting IMRN$... Pisd 07/08/21 10:43:19 AM
#154   Everybody asleep here..one day get woken up imo.. IMRN/W$... Pisd 06/03/21 11:31:46 AM
#153   A gift at $5.20 today.. total sleeper atm.. IMRN$... Pisd 05/07/21 11:29:11 AM
#152   https://www.wsj.com/articles/next-generation-of-covid-19-vaccines-could-be-pill- Pisd 05/05/21 04:09:05 PM
#151   Reiterate..holding IMRN$$..covid pill, travelers disease..etc might add $5ish, g Pisd 05/03/21 08:54:37 AM
#150   ...please tell Pisd 02/08/21 07:39:59 PM
#149   JUST LOADED UP ON THIS ONE....NEWS IMMINENT....$18-$22 BY EOW calculatedrisk 02/08/21 06:37:28 PM
#148   Vaxart huge pop/drop..covid pill vaccine.. real deal here IMRN$... Pisd 02/03/21 02:34:18 PM
#147   This ticker lies dormant until the aftermarket PR.. IMRN$... Pisd 01/22/21 10:20:03 AM
#146   Awesome pill for gut diseases likely COVID killer.. IMRN$... Pisd 12/30/20 01:33:27 PM
#145   Immuron PR Confirms Co. Recently Executed SARS-CoV-2 Research Pisd 12/15/20 08:28:03 AM
#144   * * $IMRN Video Chart 11-11-2020 * * ClayTrader 11/11/20 05:15:14 PM
#143   IMRN 8.31 G2G 11/11/20 07:20:52 AM
#142   Peeps forgot story here/moved on, not me.. patient IMRNW... Pisd 10/30/20 02:37:21 PM
#141   Buyer most I can get IMRNW..only $1 bid gl... Pisd 10/01/20 12:48:17 PM
#140   Holding free shares here, story is unchanged IMRN$ IMRNW$... Pisd 09/24/20 10:59:08 AM
#139   IMRNW$..bid/ask under $2? what a great lottery ticket imo... Pisd 08/24/20 10:39:35 AM
#138   5.5 M shares outstanding IMRN$$ ... Pisd 08/20/20 03:17:48 PM
#137   Waiting on update covid19 vaccine PILL, also progress Pisd 08/20/20 01:17:22 PM
#136   Considering getting more but need 1 or 2 Dubster watching 07/30/20 03:33:25 PM
#135   I love this stock I already made profits RealPainkiller 07/27/20 08:01:11 PM
#134   Not down from where I purchased shares. $11.45 at Dubster watching 07/27/20 07:14:53 PM
#133   It's down what are you talking about? RealPainkiller 07/27/20 06:27:56 PM
#132   Loaded some shares and slightly green. Looks like Dubster watching 07/27/20 02:53:31 PM
#131   Today need HUGE news every 3_days keep peeps attention-span... Pisd 07/27/20 02:40:21 PM
#130   IMRNW$ increase a dollar as does common $4-$5-$6 etc... Pisd 07/24/20 01:41:51 PM
#129   ...approximately seventy to eighty percent of your immune Pisd 07/24/20 12:41:11 PM
#128   Double's good?, still just getting started; COVID play.. IMRN$$... Pisd 07/24/20 10:22:12 AM
#127   This stock can't hold a gain for more RealPainkiller 07/23/20 04:17:30 PM
#126   Sold for a nice profit. Watching Dubster watching 07/23/20 01:55:21 PM
#125   idk, traded a little holding IMRN$..lot to like ... Pisd 07/22/20 09:18:21 AM
#124   * * $IMRN Video Chart 07-21-2020 * * ClayTrader 07/21/20 05:12:14 PM
#123   Yea it was nice then. Will be nice aidytrader 07/21/20 02:44:11 PM
#122   25.80 actually https://old.nasdaq.com/symbol/imrn/premarket RealPainkiller 07/21/20 02:36:56 PM
#121   If you sold pre-market it sure was. It RealPainkiller 07/21/20 02:35:57 PM
#120   Not looking as much a bargain now aidytrader 07/21/20 02:28:08 PM
#119   $20M shelf offering @ $18.75(ADS) Immuron Announces $20.0 Pisd 07/21/20 10:05:15 AM
#118   Maybe today?..Vaccine PILL for COVID19.. IMRN$, who'd a thunk?... Pisd 07/21/20 09:54:52 AM
#117   btw WARRANTS exchange for $10/share, bargain.. IMRN$ IMRNW$ ... Pisd 07/21/20 09:49:40 AM
#116   ORAL PILL vaccine LIKE VAXART killer..stay over $20 IMRN$$.... Pisd 07/21/20 09:16:13 AM
#115   HOLY F - A VIRUS STOCK NOW he-he-he-he IMRN$$... Pisd 07/21/20 07:42:40 AM
#114   Immuron Ltd. said Tuesday that a component called davidsson10 07/21/20 07:35:08 AM
#113   Immuron Reports Neutralizing Activity Against SARS-CoV-2 Key Points davidsson10 07/21/20 07:02:52 AM
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