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Meeting Abstract: 2024 ASCO Annual Meeting II
FREE ACCESS
Lung Cancer—Non–Small Cell Metastatic
June 05, 2024
Subcutaneous amivantamab vs intravenous amivantamab, both in combination with lazertinib, in refractory EGFR-mutated, advanced non-small cell lung cancer (NSCLC): Primary results, including overall survival (OS), from the global, phase 3, randomized controlled PALOMA-3 trial.
Authors: Natasha B. Leighl, Hiroaki Akamatsu, Sun Min Lim, Ying Cheng, Anna Rachel Minchom, Melina Elpi Marmarelis, Rachel E. Sanborn, … SHOW ALL …, and Antonio Passaro
Publication: Journal of Clinical Oncology
Volume 42, Number 17_suppl
https://doi.org/10.1200/JCO.2024.42.17_suppl.LBA8505
Abstract LBA8505
Background: Amivantamab (ami) plus lazertinib (laz) demonstrated antitumor activity in EGFR-mutated advanced NSCLC. Subcutaneous (SC) ami administration takes ≤7 mins and has low infusion-related reaction (IRR) rates. PALOMA-3 (NCT05388669) evaluated SC ami+laz vs IV ami+laz for pharmacokinetics (PK), efficacy, and safety among pts with EGFR Ex19del or L858R-mutated advanced NSCLC and disease progression on osimertinib and platinum-based chemotherapy.
Methods: SC ami at 1600 mg (2240 mg, ≥80 kg) was manually injected weekly for the first 4 weeks, then every 2 weeks; IV ami was given at the approved dose of 1050 mg (1400 mg, ≥80 kg). Laz was orally dosed at 240 mg daily. Co-primary PK noninferiority endpoints were trough concentration (Ctrough on Cycle [C] 2 Day [D] 1 or C4D1) and C2 area under the curve (AUCD1-D15). Key secondary endpoints were objective response rate (ORR; noninferior) and progression-free survival (PFS). OS was a predefined exploratory endpoint. Prophylactic anticoagulation was recommended for the first 4 months (mo) of treatment.
Results: In total, 418 patients (pts) were randomized (SC, n = 206; IV, n = 212); 416 received ≥1 dose. Overall, median age was 61 years, 67% were female, 61% Asian, and median 2 prior lines. At a median follow-up of 7.0 mo, PALOMA-3 met both co-primary endpoints. Geometric mean ratios (GMRs) comparing SC ami+laz vs IV for Ctrough were 1.15 (90% CI, 1.04–1.26) for C2D1 and 1.43 (90% CI, 1.27–1.61) for C4D1. GMR for C2 AUCD1-D15 was 1.03 (90% CI, 0.98–1.09). ORR was 30.1% (95% CI, 24–37) in the SC arm and 32.5% (95% CI, 26–39) for IV (relative risk, 0.92; P= 0.001), meeting the noninferiority criteria. Median duration of response (DoR) was longer for SC ami+laz vs IV (median, 11.2 vs 8.3 mo among confirmed responders). A favorable PFS trend was observed for SC ami+laz over IV (median, 6.1 vs 4.3 mo; HR, 0.84; P= 0.20). OS was notably longer for SC ami+laz vs IV (HR, 0.62; 95% CI, 0.42–0.92; nominal P= 0.017). At 12 mo, 65% were alive in the SC arm vs 51% for IV. IRRs were ~5-fold lower in the SC arm: 13% vs 66% for IV, primarily grade 1-2 (0.5% vs 4% grade ≥3, respectively). Overall, 81% received prophylactic anticoagulants, with VTE reported by 9% in the SC arm vs 14% for IV. Across both arms, VTE incidence was 10% for pts who received prophylactic anticoagulants vs 21% for pts who did not. Severe bleeding risk was low among all pts receiving anticoagulants (1% grade ≥3).
Conclusions: SC ami demonstrated noninferior PK and ORR compared to IV. Unexpectedly, DoR, PFS, and OS were longer in the SC arm vs IV, suggesting that the route of administration or formulation may affect outcomes. The safety profile was improved for SC ami, with lower IRR and VTE rates. Prophylactic anticoagulation can be safely implemented and reduces VTE risk. Clinical trial information: NCT05388669.
Source: https://ascopubs.org/doi/10.1200/JCO.2024.42.17_suppl.LBA8505
News like this makes me want to buy more shares.
“As seen in the PALOMA-3 study, with its significantly shorter administration time and five-fold reduction in infusion-related reactions, alongside longer overall survival, progression-free survival and duration of response, I look forward to seeing how subcutaneous amivantamab can make a meaningful difference in clinical practice,” Natasha B. Leighl, MD, medical oncologist at the Princess Margaret Cancer Centre in Toronto, Canada, and clinical trial investigator on PALOMA-3, told Targeted OncologyTM.
Source: https://www.targetedonc.com/view/fda-considers-subcutaneous-amivantamab-in-egfr-mutated-nsclc
Thank you for sharing this, too!
-- OJ
P.S. Seems to me like now Merck MUST respond with a subQ version of pembrolizumab, ASAP.
Thank you for sharing!
-- OJ
Great news.
Thanks for keeping us informed at all times.
Great news.
argenx Announces FDA Approval of VYVGART
Hytrulo for Chronic Inflammatory Demyelinating
Polyneuropathy
4:50 PM ET 06/21/2024 | GlobeNewswire
ARGX
argenx Announces FDA Approval of VYVGART
Hytrulo for Chronic Inflammatory Demyelinating
Polyneuropathy
VYVGART(R) Hytrulo is first and only neonatal Fc receptor (FcRn) blocker approved to treat chronic inflammatory demyelinating polyneuropathy (CIDP)
First novel, precision mechanism of action in more than 30 years for patients with CIDP
Third approved indication for VYVGART(R) and
VYVGART Hytrulo franchise
Management to host conference call on June 21, 2024 at 11:00pm CET (5:00pm ET)
Bristol Myers Squibb (NYSE:BMY) announced Friday that the EU drug regulator, the European Medicines Agency (EMA), validated its request to expand the approval for its cancer therapy Opdivo (nivolumab) to include a subcutaneous formulation.
The PD-1 immune checkpoint inhibitor is already approved in the region as an intravenous infusion for several forms of solid tumors as a single agent or in combination with other medications, such as BMY’s CTLA-4-blocking antibody, Yervoy.
https://seekingalpha.com/news/4117867-bristol-myers-opdivo-injectable-accepted-eu-review?source=content_type%3Areact%7Csection%3AAll%7Csection_asset%3ANews%7Cfirst_level_url%3Asymbol%7Cbutton%3ATitle%7Clock_status%3ANo%7Cline%3A1
So S. Korea's Alteogen gets some of HALO's rHuPH20 & mysteriously makes their HLB3-002 & brags that it is a "standalone" of Halozyme's rHuPH20 & has the same amino acid sequence. They mix a "trypan blue dye" with each "original" & mix HLBC-002 & shoot it into a shaved rat's neck & watch it disperse & confirm diffusion. (TAKEN FROM THEIR WEBSITE.)
What about the years of human testing mixed with specific IV meds & lengthy testing on actual cancers?
Isn't HALO's rHuPH20 is a "standalone" until it's used - formulated to change any small or large molecule IV drug into a subcutaneously administered medicine ? Add the lengthy testing of each, of course.
This is patent infringement (& they're a decade behind getting anything approved.) Unless they only want to make blue rats! You want it used on you anytime soon ?
"Phase 3 PALOMA-3 results showing five-fold reduction in infusion-related reactions with five-minute administration of subcutaneous amivantamab
Longer overall survival, progression-free survival and duration of response also observed with subcutaneous amivantamab"
These results are excellent and unprecedented. They should really help Halozyme in their sales pitches to potential new partners. This is the second piece of unexpected good news this month. The first one obviously was the new patent in EU grant. We may get some expected good news on Friday with the Hytrulo for CIPD approval. All of the above may push the stock over $53.
Goes down in price in the morning when there is no new deals announced and comes back up later in the day in anticipation of news the next morning.
Market participant are expecting new Enhanze, auto-injector and auto-injector+ enhanze deals
Interesting. I wonder when this and Alteogen's will get approved. It's certainly odd that they have been able to develop a "standalone" before Halo's patents expire. In any case, this is one of the reasons Halo should not rely just on Enhanze and get serious on M&A imo.
"HLB3-002 is a standalone of Halozyme's rHuPH20 (Original) and has the same amino acid sequence."
I suppose that the interest rates moderating may happen, then again it might not. In an election year I wouldn’t bet on anything, without getting too explicit. I think that people much more plugged in than I am have already placed their bets, so some of that is already factored into the market. As far as “a few deals” the Karin interview only revealed the high level of excitement at Halozyme, but little else in a concrete way. It restated again what has been restated a number of times in the past. Deals are good, great possibilities but we don’t know when. As far as M&A, the best possible thing would be a sale of Halozyme, IMO. There is little cash currency for a worthwhile acquisition, thanks to the ATRS deal, and one has the feeling of a college try to boost the stock price, as stock is the only currency available in quantity to Halozyme at this point.
Regarding the markets as a whole, I would add that if interest rates start to moderate in the next 2 Qs, it will be accretive to the wind which is currently at Helen's back. Hopefully, even she might be able to cobble together a few deals by year's end in this set of circumstances.
Thanks for the link. I agree that Karin did a good, balanced, interview, resisting the prompts to be “excited” or “amazed”. As even the known knowns and known unknowns are a subject of disagreement, I leave the Halozyme specific subjects alone, we all have our own understanding of them and act accordingly. I am sure that some of those who might atribute some importance to the market as a whole, in which Halozyme plays a very small role, may feel a degree of apprehension about it, plenty of material available on the subject, and search for what they deem the best deployment of their assets.
Nice little 6-7% hair cut since the 52 week high of $53.
Mr. Market gives you gifts. Dips are to be bought when you are dealing with QUALITY.
Here is a link to the webcast. In short, nothing specific. She does go into a broad overview of the opportunities that are available. Worth a listen, start after minute 10, because the beginning is just the usual boilerplate blather. The moderator Karin, is exceptionally well informed and keeps the conversation focused and concrete. See HALO's website for the link if the below link doesn't work.
https://event.webcasts.com/viewer/event.jsp?ei=1675689&tp_key=ac9b8c7af4
Any mention of new deals in the works?
I found today's talk at the Goldman event to be very good. The Goldman host (I didn't get her full name, but it was Caryn or such) kept Helen's feet to the fire and asked very probing questions; much better than the usual softballs at these types of programs.
Hi Fred:
Thanks for the compliment, but I really have no idea. I need to restrict my commentary to something I actually know something about.
Best regards,
OJ
Latest Corporate Slide Set 6.10.24
https://s28.q4cdn.com/284259014/files/doc_presentation/2024/06/10/HALO-Corporate-Deck-June-2024-FINAL.pdf
Haha, I muted him/her a while ago.
Yes we all know that. However, 1) they have not advanced anything into clinic with Halo. 2) The Alzheimer’s partnership for Acumen was non-exclusive so Liliy’s donanemab could still be in play
Advisory panel voted 11-0 in favor of Lilly’s Alzheimer’s therapy which is currently an IV infusion once every 4 weeks for minimum of 18 months. No one thinks that 18 IV infusion sessions are practical for so many patients with Alzheimer’s, especially since the infusion centers are already way overbooked.
This is why Biogen & Esai are working on an injectable version of their already approved IV Alzheimer’s therapy.
Lilly will be coming to the market with some lag behind Biogen but if/when they partner with halozyme, it will be the lead.
If/when Lilly announces a partnership with Halo, it will be game-set-match for the halo bears. You will see them go quiet for good.
biotechinvestor1:
You have a good weekend ! Ben a special week.
Icing on the cake (Lilly Donanemab, read to the end) Despite the recent run up, Halozyme’s share price is still an amazing bargain when you consider its estimates from Nasdaq:
PE
2024-14.78
2025-12.05
2026-9
PEG-0.57
With the recent patent extensions (EU done and US pending) and the raised 1 and 5 year EPS CAGR as well as halo already impressive and growing profit margin, it’s not difficult to predict a complete re-rating of the stock by market participants and a PE ratio in the high 20’s. This would be more consistent with halo’s peers in the biopharma and would easily put in the $70-$90 range.
What would put halozyme on front page financial news and take it far above $90 would be a partnership with Liliy on what is likely be a blockbuster Alzhimers drug. Donanemab is currently administered intravenously every 4 weeks for 18 months. That is a minimum 18 times that patient has to go to an infusion center, get an IV started (not easy in elderly who lack good peripheral veins) and sit there for a long period of time. Halozyme can make this an easy 5 minute SC at home.
me too
Boy, easycomeandgo is annoying, however!
Even with the recent run up and not even factoring in the raised earnings guidance from yesterday, the 2024 PE ratio is still at 14.95 and PEG is 0.58. Halo is still an incredible bargain for the impressive and growing profit margins and growing EPS CAGR most companies would die for.
The fact that all the long term halo bears continue to post here is a good sign. I will take profit when they give up and there is clear sign of capitulation.
https://www.nasdaq.com/market-activity/stocks/halo/price-earnings-peg-ratios#google_vignette
Transaction executed.
I see that there is analyst action excitement. Bulls and bears do OK, pigs get slaughtered. I am just a piglet. Among the upgrades, it is noteworthy that Goldman Sachs raised their price target for Halozyme from $41 to $44.
To lighten the atmosphere, I also see that Vladimur (soul purity certified by the formidable Dubya scan) dispatched some naval assets to Cuba as a friendly gesture. Half of his heart is in Havana, oooh-nana.
Further, I see that the US economy added a ton of new jobs, even as the unemployment rate climbed. Put that in your these days so frequently discussed pipe, and smoke it. Whoa…! Do any numbers exist still which haven’t been fudged? The price of oil is forecast to both increase and decrease. Quantum economics. Superposition. Schroedinger’s Oil. Jamie Dimon might still prove to be right. Have a nice day.
Piper Sandler downgrades HALO to Neutral, moves PT from $48-$51.
$HALO Halozyme price target raised to $58 from $48 at Wells Fargo
Wells Fargo raised the firm's price target on Halozyme to $58 from $48 and keeps an Overweight rating on the shares. The firm adjusted its model for the company's updated royalties post the new European Union patent. Halozyme's new patent seems to be a manufacturing related patent which covers manufacturing of the product using a specific process, the analyst tells investors in a research note. The company said that approved, and pipeline products within Wave's 1/2/3 have collaboration patents granted or pending, and is confident in patents pending, Wells points out.
$HALO Halozyme price target raised to $65 from $50 at H.C. Wainwright
Onco, given your level of expertise, I wonder what your opinion is as to the argument that Merck was forced to go to Alteogen due to an exclusivity clause in the HALO contract with Merck's competitor. TIA. -Fritz
It’s good to see that some of the posters with bearish views have not given up. Capitulation often means a top. We certainly don’t see that here.
Well, the market certainly seems to think Alteogen has good prospects. Their market cap is over $2.3B and their stock has appreciated 395% (Iyr.), 1,940% (5yr.), 7,870% (10yr.). So, I wish Halo had bought Alteogen instead of Antares and if we are going to sue them, we'd better have a very strong case.
https://finance.yahoo.com/quote/196170.KQ/
i'm not 100% sure but i think many years back Halo was testing PEGPH20 with Keytruda on their own dime for a while and clearly nothing happened. That's as close as they ever got. Merck should have made a deal with Enhanze but knowing what i know today they will regret not making that decision. I'll repeat what I've been saying. Halo is a cash generating machine and competitors will have a very difficult time breaking into this market. I think that Mark Snyder was very telling in the way he answered the question on Keytruda SC this morning.
Very impressive news in the last few weeks and much more to come. Looking forward to new highs in the near future.
I waited, and now I’ll take the profits, as planned. Gone long term. Thanks IBD, good call!
I guess EasyCom left without saying goodbye. So long (or was it so short)!
Powerful insight. Thank you
agree we need more deals, but this new patent news is a breath of fresh air while we wait
Agree.. Competition in the immune checkpoint inhibitor (ICI) marketplace is only going to heat up. I write about advanced cancer medicine every day. You should see how many ICIs -- both PD-1 inhibitors and PD-L1 inhibitors, as well as agents directed against even fancier targets like LAG3 and TIGIT -- are being developed in places like Beijing and Shanghai. Theoretically, every one of these could be a candidate for a collaboration agreement with HALO as a way to improve patient/provider convenience, increase competitive advantage, and increase market share.
From my perspective, HALO can now be called a true pick-and-shovel stock, selling competitive advantage to more and biotech prospectors, large and small, who are trying to strike it rich in the immuno-oncology drug gold rush.
I think that this was obviously unexpected and very good news. However, the major hurdle remains the slowing growth both in royalties and total revenues starting in 2028, which is only 4 years away. The growth rate goes from 29% (royalties) and 20% (total revenues) in 2027 to 5% for both in 2028. Ideally, you want to have visibility and good growth for ten years. If and when the pending patents for Tecentriq SC and Hytrulo are issued, that will help. But I think another acquisition and more deals are needed to take this company to the next level.
What do you even know about "up tempo?"
Thanks, though I don't remember Helen addressing this directly in previous calls. I may have overlooked it at the time. Still, my main point about forging new deals in an up-tempo way remains.
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http://www.halozyme.com
Halozyme is a biopharmaceutical company developing and commercializing products based on the extracellular matrix for the drug delivery, oncology, and dermatology markets. The company's portfolio of products is based on intellectual property covering the family of human enzymes known as hyaluronidases.
The company's Enhanze Technology is a novel drug delivery platform designed to increase the absorption and dispersion of biologics. Its first partnership is with Roche to apply Enhanze Technology to Roche's biological therapeutic compounds for up to 13 targets. In addition, the company has received FDA approval for two products: Cumulase® and HYLENEX, for use as an adjuvant to increase the absorption and dispersion of other injected drugs and fluids. HYLENEX is partnered with Baxter Healthcare Corporation. The Company also has a number of different enzymes in its portfolio that are targeting significant areas of unmet need.
Halozyme is a therapeutically driven biopharmaceutical company developing and commercializing recombinant human enzymes to provide enhanced and innovative alternatives that improve the practice of medicine. Halozyme is focused on providing life-saving and life-enhancing solutions to the drug delivery, oncology, and dermatology markets.
Products/Pipeline
Halozyme is a therapeutically driven biopharmaceutical company developing and commercializing recombinant human enzymes to provide enhanced and innovative alternatives that improve the practice of medicine. Halozyme is focused on providing life-saving and life-enhancing solutions to the drug delivery, oncology, and dermatology markets.
The foundation of our capabilities is our recombinant human hyaluronidase enzyme, rHuPH20, which temporarily degrades hyaluronan, a structural protein in the interstitial space. This temporary alteration provides an opportunistic window that allows the delivery of injectable biologics such as monoclonal antibodies, as well as small molecules and fluids. With our enzyme, many pharmaceuticals that would normally be injected intravenously (IV) can be administered subcutaneously (SC). This change in route of delivery may improve patient convenience, enhance pharmacokinetics, boost efficacy, extend the product lifecycle, and reduce cost, in addition to other attributes.
Four key internal programs comprise our current proprietary product development portfolio. The endocrinology franchise consists of Insulin-PH20, which applies our PH20 enzyme to currently approved and marketed insulin products. The oncology franchise consists of PEGPH20, a new molecular entity administered intravenously that targets the external environment of tumor cells, and Chemophase, which utilizes the PH20 enzyme for local administration in bladder cancer. Our lead enzyme in the dermatology franchise, HTI-501, is a new molecular entity which digests collagen and may have applications in both medical and aesthetic dermatology such as cellulite.
Our product development pipeline also includes three distinct partnered programs with two companies; Roche and Baxter BioScience for Enhanze technology, and a partnership with Baxter Medication Delivery for Hylenex, our FDA-approved drug. These partnered programs validate our technology and may generate clinical and commercial milestone revenue based on the achievement of pre-specified events along with sales royalties when products reach the commercial stage. We utilize the cash milestone payments generated from the partnered programs as a source of development funding for our proprietary pipeline projects.
Endocrinology
Our endocrinology development activity focuses on insulin, a mainstay of treatment for people with diabetes. This program combines our PH20 hyaluronidase enzyme with insulin, a frequently prescribed, commercially successful pharmaceutical already approved and on the market.
We believe that the combination of our PH20 enzyme with existing, meal time insulin products such as regular insulin or a fast acting analog could lead to a best-in-class product that more closely mimics the release of natural insulin in the body. The results of a Phase 1 study, where we combined PH20 with Humulin® R (regular human insulin) and with Humalog® (insulin lispro), demonstrated significantly faster and higher insulin plasma concentrations compared to either insulin alone. Faster acting insulin could provide patient benefits such as reduced hypoglycemia, lower intra-subject variability, and less weight gain. These potential benefits would be significant but must first be demonstrated and proven in clinical development.
Our first Phase 2 clinical trial with insulin began in October 2008 and enrolled Type 1 diabetic patients. Data presented from our Phase 1 trial showed that the administration of regular insulin and an insulin analog with our PH20 enzyme led to faster insulin absorption and more rapid effects than either insulin alone. Our Phase 2 trial is designed to demonstrate similar results in Type 1 diabetic patients. We hope to present preliminary Phase 2 results at the American Diabetes Association meeting in June. Additional clinical trials are planned in 2009.
ONCOLOGY
Hyaluronan (HA) is a component of the extracellular matrix that frequently accumulates in human cancers. The quantity of HA produced by the tumor cells directly correlates with increased tumor growth and metastasis and it has been linked with tumor progression and poor prognosis. Previous clinical trials of bovine hyaluronidase showed promise in enhancing chemotherapy regimens using adjunctive systemic hyaluronidase in chemo-refractory patients. In animal studies the removal of HA from tumors with hyaluronidase has demonstrated improved survival, suppression of tumor growth, and enhanced efficacy of certain anti-cancer drugs. Chemotherapeutic agents may be able to better penetrate the tumor once the HA has been removed.
We have also observed significant reduction of tumor interstitial fluid pressure (IFP) following the administration of rHuPH20 in solid tumors grown in mice. Tumor interstitial pressure is widely believed to be an important factor limiting the access of cytostatic regimens to solid tumors. By digesting the HA gel, rHuPH20 may reduce IFP in the tumor and promote more effective delivery of chemotherapy throughout the tumor. This could potentially lead to better patient outcomes and increased survival.
Our PEGPH20 program utilizes pegylated hyaluronidase that allows for intravenous administration to degrade the HA that surrounds tumor cells. The Chemophase program applies the hyaluronidase enzyme along with mitomycin C directly into the bladder where the enzyme can hydrolyze the HA produced by the cancerous bladder cells. Unlike tumor cells, normal cells do not produce HA in this manner and appear not to be adversely affected by the enzyme.
We are investigating pegylated-rHuPH20, or PEGPH20, a new molecular entity, as a candidate for the systemic treatment of tumors rich in hyaluronan, or HA. Pegylation refers to the attachment of polyethylene glycol to our rHuPH20 enzyme, which extends its half life from less than 30 seconds to more than 24 hours. Numerous solid tumors, including prostate, breast, pancreas, colon and non-small cell lung, accumulate HA that forms a halo like coating over the surface of the tumor cell.
In preclinical studies, PEGPH20 has been shown to remove the HA coating surrounding several tumor cell lines. Treatment of PC3 (a prostate cancer cell line that produces HA) tumor bearing mice with PEGPH20 as a single agent demonstrated approximately 70% tumor growth inhibition relative to controls. Repeat dosing with PEGPH20 produced a sustained depletion of HA in the tumor microenvironment. For tumor models that do not produce HA, the presence of PEGPH20 has no effect. An estimated 20% to 40% of certain solid tumors may produce HA.
Administration of the combination of PEGPH20 with docetaxel or with liposomal doxorubicin in HA producing animal tumor models produced a significant survival advantage for the combination relative to either chemotherapeutic agent alone. Therefore, based on these animal studies and other tests conducted by Halozyme, PEGPH20 may represent a potentially innovative treatment approach against tumors that produce HA.
PEGPH20 recently started its first Phase 1 clinical trial which will evaluate the agent over a range of doses. The study will enroll up to 46 advanced cancer patients who will receive treatment cycles of intravenous PEGPH20 as a single agent twice weekly for three weeks followed by one week without dosing. Patients may continue subsequent cycles at their assigned dose as long as there is no tumor progression and no unacceptable toxicity. Groups of four to eight patients will be in each dosage cohort. The primary outcome measures of the study will be to evaluate safety and tolerability of PEGPH20 and to determine the recommended single agent Phase 2 dose. Secondary objectives will be to determine pharmacokinetics, obtain dose limiting toxicities, and observe patients for any evidence of anti-tumor activity.
Chemophase is a chemoadjuvant we have investigated for possible use in the treatment of patients with superficial bladder cancer, which represents a smaller potential market than our other proprietary pipeline opportunities. The Chemophase program combines our PH20 enzyme with mitomycin C, a cytotoxic drug, for direct administration into the bladder immediately after transurethral resection of bladder tumors (TURBT), a standard surgical treatment for the disease. Many bladder tumor cells produce high quantities of HA and thus treatment to remove the HA coating could increase their exposure to mitomycin C. This may lead to a lower recurrence of the cancer and a better prognosis for patients.
In June 2008, we announced the interim results of a Phase I/IIa clinical trial in which the Chemophase combination treatment of mitomycin C plus rHuPH20 enzyme was well tolerated and appears safe. The study reported no dose-limiting toxicities and no observed side effects attributable to the enzyme. An ongoing safety trial involves the immediate post operative (IPOP) administration of PH20 and mitomycin directly into the bladder of patients after a TURBT procedure.
DERMATOLOGY
The foundation of our dermatology program is HTI-501, a human lysosomal proteinase that degrades collagen. It may be useful in the treatment of both medical and aesthetic dermatologic conditions such as cellulite, Dupuytren’s contracture and Peyronie’s disease. This pH sensitive enzyme demonstrates activity under mildly acidic conditions but shows no activity at normal physiologic pH. This attribute may be harnessed to exert control over the duration and location of the enzyme’s therapeutic activity.
Tests with HTI-501 in several animal models have produced encouraging results and our pre-clinical investigations of the enzyme will continue throughout 2009.
ENHANZE
Enhanze™ Technology, a proprietary drug delivery platform using Halozyme’s first approved enzyme, rHuPH20, is our broader technology opportunity that can potentially lead to partnerships with other pharmaceutical companies. When co-formulated with other injectable drugs, Enhanze Technology may facilitate the penetration and dispersion of these drugs by temporarily opening flow channels under the skin.
Molecules as large as 200 nanometers may pass freely through the extracellular matrix, which recovers its normal density within approximately 24 hours, leading to a drug delivery platform which does not permanently alter the architecture of the skin. The principal focus of our Enhanze Technology platform is the use of rHuPH20 to facilitate subcutaneous or intramuscular routes of administration for large molecule biological therapeutics. We are seeking partnerships with pharmaceutical companies that market drugs requiring or benefiting from injection via the subcutaneous or intramuscular routes that could benefit from this technology. In December 2006, we signed our first Enhanze Technology partnership with F. Hoffmann-La Roche Ltd and Hoffmann-La Roche, Inc. In September 2007, we signed our second Enhanze Technology partnership with Baxter Healthcare Corporation and Baxter Healthcare S.A.
HYLENEX
Full prescribing information is available below or at www.hylenex.com
Hylenex is a human recombinant formulation of rHuPH20 to facilitate the absorption and dispersion of other injected drugs or fluids. When injected under the skin or in the muscle, hyaluronidase can digest the hyaluronic acid gel, allowing for temporarily enhanced penetration and dispersion of other injected drugs or fluids. We filed a New Drug Application (NDA) in March 2005 and we received approval of our Hylenex NDA in December 2005.
Hylenex may facilitate subcutaneous delivery of fluids up to one liter without the need for intravenous access, a procedure known as EASI. Importantly, EASI for fluid replacement in terminal patients may be achieved with limited or no need for nursing assistance. Over 1.1 million subcutaneous fluid infusions are performed per year with hospice patients alone (Source: Company estimates based on National Hospice and Palliative Care Organization data, 2001). In addition, over 500 million infusion bags are utilized annually in the United States, some of which could potentially convert to EASI using Hylenex, giving rise to additional market potential (Source: B. Braun, 2003).
During January 2006, we completed the INcreased Flow Utilizing Subcutaneously-Enabled Lactated Ringer’s clinical trial, or INFUSE-LR study, which was designed to determine the subcutaneous (Sub-Q) infusion flow rate of Lactated Ringer’s solution with and without Hylenex, determine the Sub-Q infusion flow rate dose response to Hylenex over one order of magnitude of dose, and assess safety and tolerability. This prospective, double-blind, randomized, placebo-controlled, within-subject, dose-comparison study enrolled 54 volunteer subjects who received Sub-Q infusions simultaneously in both upper arms through 24 gauge catheters.
During October 2006, we completed the INcreased Flow Utilizing Subcutaneously-Enabled Morphine clinical trial, or INFUSE-Morphine study, which was designed to determine the time to maximal blood levels of morphine after subcutaneous administration with and without Hylenex, to determine the time to maximal blood levels after intravenous administration of morphine, and to assess safety and tolerability. This prospective, double-blind, randomized, placebo-controlled, within-subject, dose-comparison study enrolled 12 evaluable patients who received Sub-Q infusions.
For full prescribing information, visit www.hylenex.com or www.baxter.com.
CUMULASE
Cumulase is an ex vivo (used outside of the body) formulation of rHuPH20 to replace the bovine enzyme currently used for the preparation of oocytes (eggs) prior to IVF during the process of intracytoplasmic sperm injection (ICSI), in which the enzyme is an essential component. The enzyme strips away the hyaluronic acid that surrounds the oocyte. This allows the clinician to then perform the ICSI procedure, injecting the sperm into the oocyte. The FDA considers hyaluronidase IVF products to be medical devices subject to 510(k) approval and we filed our 510(k) application during September 2004.
We received FDA clearance in April 2005. We launched Cumulase in the European Union and in the United States in June 2005. We believe the total ICSI market consisted of an estimated 500,000 intracytoplasmic sperm injection cycles worldwide in 2005 (Source: CDC, 2001; ESHRE, 2002).
Visit www.cumulase.com for more information.
Informative Links
http://www.nasdaq.com/asp/Holdings.asp?FormType=Institutional&page=holdingssymbol=HALO&selected=HALO
(Institutional Holdings)
http://www.cnbc.com/id/15837275?q=HALO
(Big Block Holders from CNBC)
http://www.sec.gov/edgar/searchedgar/companysearch.html
(SEC filings search from SEC.gov Edgar)
http://www.nasdaqtrader.com/Trader.aspx?id=shortinterest (Short Interest)
http://www.newratings.com/main/search_result.m?section=search
(Analyst Ratings)
http://www.insidercow.com/history/company.jsp?company=HALO&B1=Search%21
(Insider Transactions)
http://clinicaltrials.gov/ct2/results?term=rhuph20
http://clinicaltrials.gov/ct2/results?term=hyaluronidase+%28human+recombinant%29
(Clinical Trials)
Clinicals & Partners
http://media.corporate-ir.net/media_files/irol/17/175436/120506RocheHalozymePR.pdf
Halozyme and Roche enter agreement for the application of Enhanze, a novel technology to improve drug delivery
http://media.corporate-ir.net/media_files/irol/17/175436/RocheHalozymeSCRIPPresentation.pdf
(Halozyme and Roche presents “Developing and Managing Strategic Alliances” at the SCRIP conference
May 15-16, 2007 Berlin, Germany)
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1049931&highlight=
Baxter and Halozyme Announce Collaboration for Development of Subcutaneous GAMMAGARD LIQUID(TM) Administration Using Enhanze(TM) Technology
http://www.genengnews.com/news/bnitem.aspx?name=32185399
Baxter Presents Latest Clinical Trial Results of GAMMAGARD LIQUID Administered Subcutaneously (Enhanze 3-16-08)
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=962993&highlight=
Halozyme and Baxter Expand Global HYLENEX Collaboration
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=IROL-secToc&TOC=aHR0cDovL2NjYm4uMTBrd2l6YXJkLmNvbS94bWwvY29udGVudHMueG1sP2lwYWdlPTU0NDgxMjkmcmVwbz10ZW5r (Feb. 12, 2008 Slide Show Presentation)
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1093211&highlight=
Halozyme Therapeutics Announces Peer-Reviewed Publications of the INFUSE-LR Clinical Trial Results and Clinical Practice Experience With Hylenex
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1117082&highlight=
Halozyme Therapeutics Presents Favorable New Safety and Pharmacokinetic Data on rHuPH20 Enzyme Produced Via New Manufacturing Process at European Federation for Pharmaceutical Sciences
Halozyme Therapeutics Presents Findings on Combinations of rHuPH20 Enzyme With Bisphosphonates at the American Association for Cancer Research Conference
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1130327&highlight=
Halozyme Therapeutics Presents Pre-Clinical Studies on Dermal Remodeling With HTI-501, a Lysosomal Proteinase
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1147853&highlight=
http://www.baxter.com/about_baxter/news_room/news_releases/2008/03-16-08-gammagard_liquid.html
Phase I/II data showed that Enhanze Technology™ enabled subcutaneous administration of a monthly dose of GAMMAGARD LIQUID in patients with Primary Immunodeficiency
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1163612&highlight=Halozyme Therapeutics Announces Phase I Clinical Trial Results Demonstrating that the Combination of Recombinant Human Hyaluronidase (rHuPH20) With Humulin R(R) and with Humalog(R) Yields Faster, More Physiologic Insulin Kinetics and Better Predictability
Cheetah full ADA presentation
http://www.halozyme.com/images/ADA%202008%20Poster%20legal.pdf
Halozyme Therapeutics Announces Positive Findings With Pegylated Enzyme in Prostate Cancer Models
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1177539&highlight=
Halozyme Therapeutics Announces That Chemophase Meets Primary Endpoint in Phase I/IIa Clinical Trial
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1170737&highlight=
Halozyme Therapeutics Begins Phase 2 Clinical Trial of Insulin With rHuPH20 in Type 1 Diabetic Patients
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1220870&highlight=
Halozyme Therapeutics Announces Roche Begins Phase 1 Clinical Trial and Selects Fourth Exclusive Biologic Target
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1233454&highlight=
Halozyme Therapeutics Begins Phase 1 Clinical Trial of Bisphosphonate Administered With rHuPH20 Enzyme
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1234643&highlight=
Halozyme Deprioritizes Bisphosphonate Program to Reallocate Resources to More Commercially Attractive Internal Programs
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1295922&highlight=
Phase III Trial Begins for GAMMAGARD LIQUID Plus rHuPH20 in Primary Immunodeficiency Patients
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1240232&highlight=
Halozyme Therapeutics Announces Roche Begins Phase 1 Clinical Trial With Second Biologic
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1244971&highlight=
Halozyme Therapeutics Presents Positive Pre-Clinical Single Agent Data for PEGPH20
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1248119&highlight=
AACR presentations show that PEGPH20 produces anti-cancer activity in models of breast, prostate, and brain metastases that produce hyaluronan
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1277960&highlight=
Phase 1 Study for Halozyme's Insulin-PH20 Published, Highlights Findings for Faster Acting Insulin Formulations |
|
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1293715&highlight=
Accelerated Insulin Pharmacokinetics and Improved Glycemic Control in T1DM Patients by
Coadministration of Prandial Insulin with Recombinant Human Hyaluronidase
http://www.halozyme.com/ADA%202009%20Poster%20v3%202.pdf
Halozyme Announces Roche Selects Fifth Exclusive Biologic Target
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1297519&highlight
Baxter and Halozyme Announce Completion of Patient Enrollment in Phase III Pivotal Trial of GAMMAGARD LIQUID(TM) with rHuPH20 Enzyme
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1307856&highlight=
First patient dosed in trial with third Roche biologic formulated with Halozyme’s recombinant human hyaluronidase enzyme
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1330295&highlight=
Baxter Announces the Commercial Launch of HYLENEX at ACEP for Use in Pediatric Rehydration |
Data from the First Pediatric Rehydration Study, INFUSE-PEDS 1, Published Today in Pediatrics |
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1338559&highlight=
Halozyme Announces Roche Doses First Patient in Phase 3 Clinical Trial with Subcutaneous Herceptin(R)
http://phx.corporate-ir.net/phoenix.zhtml?c=175436&p=irol-newsArticle&ID=1344910&highlight=
Earnings Transcripts
http://seekingalpha.com/article/68609-halozyme-therapeutics-q4-2007-earnings-call-transcript?source=yahoo&page=1
Halozyme Therapeutics Q4 2007 Earnings Call Transcript
http://seekingalpha.com/article/76655-halozyme-therapeutics-inc-q1-2008-earnings-call-transcript?source=yahoo
Halozyme Therapeutics Inc. Q1 2008 Earnings Call Transcript
http://seekingalpha.com/article/90080-halozyme-therapeutics-inc-q2-2008-earnings-call-transcript?source=yahoo&page=1
Halozyme Therapeutics Inc. Q2 2008 Earnings Call Transcript
http://seekingalpha.com/article/106797-halozyme-therapeutics-inc-q3-2008-earnings-call-transcript?source=yahoo
Halozyme Therapeutics, Inc. Q3 2008 Earnings Call Transcript
http://seekingalpha.com/article/125929-halozyme-therapeutics-inc-q4-2008-earnings-call-transcript?source=trans_sb_previous
Halozyme Therapeutics, Inc. Q4 2008 Earnings Call Transcript
http://seekingalpha.com/article/171883-halozyme-therapeutics-inc-q3-2009-earnings-call-transcript?source=yahoo
Halozyme Therapeutics, Inc. Q3 2009 Earnings Call Transcript
Links to understanding Clinical results
http://www.boomer.org/c/p3/c02/c0210.html
http://health.yahoo.com/other-other/picomoles-per-liter-pmol-l/healthwise--stp1694.html
http://www.unc.edu/~rowlett/units/scales/clinical_data.html
http://www.bio.net/bionet/mm/immuno/2000-July/015983.html
http://www.boomer.org/c/p1/
http://www.merck.com/mmpe/sec20/ch303/ch303a.html
Shares Outstanding: 91,095,288
Float: 73.21M
http://www.deepcapture.com/
(O-T How the market is manipulated and companies destroyed)
Halozyme Therapeutics Inc.
11588 Sorrento Valley Road
Suite 17
San Diego, CA 92121
United States
Phone: 858-794-8889
Halozyme Contact
Robert H. Uhl
Senior Director Investor Relations
858.704.8264
ruhl@halozyme.com
(Disclaimer) Do your own DD and confirm anything said on this board.
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