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Geron Corp. (GERN)

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 Geron Corp (GERN)




Company Information:
Geron Corporation
230 Constitution Drive
Menlo Park, CA 94025 USA
Tel: 650-473-7700
Fax: 650-473-7750

                                     Imetelstat, a first-in-class telomerase inhibitor and our sole product candidate, is being developed for the potential treatment of hematologic myeloid                                                                                                          malignancies. Imetelstat is currently in two clinical trials being conducted by Janssen under the terms of an exclusive worldwide collaboration and license agreement

CIK:  0000886744 

Geron is developing first-in-class biopharmaceuticals for the treatment of cancer and chronic degenerative diseases, including spinal cord injury, heart failure and diabetes. The company is advancing an anti-cancer drug and a cancer vaccine that target the enzyme telomerase through multiple clinical trials in different cancers.

Incorporated in the state of Delaware in 1990, Geron has been in business since 1992. Our headquarters and main facilities are located in Menlo Park, California. Geron Bio-Med Limited is our wholly-owned subsidiary located in Edinburgh, Scotland. TA Therapeutics, Limited is our majority-owned subsidiary located in Hong Kong.


Executive Management:



Geron Bio-Med Ltd

TA Therapeutics


Recent News: 




Transfer Agent:
Computershare Trust Company, N.A.
250 Royall Street
Canton, MA 02021
Tel: 1-800-962-4284
Fax: 303-262-0700


Investor Relations:

Tel: 650-473-7765



Geron Clinical Trials








Acute Myelogenous Leukemia is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.

Alzheimer's Disease: Alzheimer's disease is a progressive, fatal, degenerative disorder that attacks the neurons in the brain, resulting in loss of memory, cognitive function such as reasoning and language, and behavioral changes. The disease starts with the loss of neural connections, called synapses, in the hippocampus, affecting memory, and progresses to the cortex affecting language and thought.

Antiplatelet: Medication, including aspirin and newer agents used to prevent clumping together of platelets, one of the first things to occur in artery clotting. Platelet clumping is a risk factor for stroke.

Autologous refers to cells, tissues or even proteins that are reimplanted in the same individual as they come from. Bone marrow, skin biopsy, cartilage, and bone can be used as autografts.

A Chromosome is a part of a cell in an animal or plant. It contains genes which determine what characteristics the animal or plant will have.

Cytogenetics is a branch of genetics that is concerned with the study of the structure and function of the cell, especially the chromosomes.

Dendritic is a short branch at the end of a nerve cell, which receives signals from other cells.

Ecchymosis is the escape of blood from ruptured blood vessels into the surrounding tissue to form a purple or black-and-blue spot on the skin.

The Hippocampus is a major component of the brains of humans and other mammals. It belongs to the limbic system and plays important roles in long-term memory and spatial navigation.

Idiopathic is an adjective used primarily in medicine meaning arising spontaneously or from an obscure or unknown cause.

Immunotherapy is a medical term defined as "Treatment of disease by inducing, enhancing, or suppressing an immune response"

Interim is used to describe something that is intended to be used until something permanent is done or established.

Intracranial: Of or pertaining to the brain or inside of the head. Within the cranium.

Leukapheresis is a laboratory procedure in which white blood cells are separated from a sample of blood.

The Limbic system (or Paleomammalian brain) is a set of brain structures including the hippocampus, amygdala, anterior thalamic nuclei, and limbic cortex, which support a variety of functions including emotion, behavior, long term memory, and olfaction.[1] The term "limbic" comes from Latin limbus, loosely translating as "border" or "belt".

Lysosome: A sac-like compartment inside a cell that has enzymes that can break down cellular
components that need to be destroyed.

Macrophages: A large cell that acts as a scavenger, helping the immune system to destroy foreign agents.

Remission If someone who has had a serious disease such as cancer is in remission or if the disease is in remission, the disease has been controlled so that they are not as ill as they were.

T cells or T lymphocytes belong to a group of white blood cells known as lymphocytes, and play a central role in cell-mediated immunity. They can be distinguished from other lymphocyte types, such as B cells and natural killer cells by the presence of a special receptor on their cell surface called T cell receptors (TCR).

Thrombocytopenic purpura A systemic illness characterized by extensive ecchymoses and hemorrhages from mucous membranes and very low platelet counts; resulting from platelet destruction by macrophages due to an antiplatelet factor; childhood cases are usually brief and rarely present with intracranial hemorrhages, but adult cases are often recurrent and have a higher incidence of grave bleeding, especially intracranial.
Transfection of animal cells typically involves opening transient pores or "holes" in the cell membrane, to allow the uptake of material. Genetic material (such as supercoiled plasmid DNA or siRNA constructs), or even proteins such as antibodies, may be transfected.

NOTE: Definitions found with Google. All comments or suggestions are welcome.

_____________________________________________________________________________________________________________________________________________________________________________ ARE TELOMERES AND TELOMERASE ?

Geron Corporation is a biotechnology company founded by Dr. Michael D. West based in Menlo Park, California. The company was incorporated in 1990 and began doing business in 1992. Geron Corporation focuses on creating drugs based on telomere and stem cell research[3].

Geron is traded on the NASDAQ under the symbol GERN. The current chief executive officer is Dr. Thomas B. Okarma, M.D., Ph.D. It was included in the SCCC Index, a 15 stock index of companies important "to the field of stem cell, cloning, and cell transplantation research and medicine" when that index was created in 2003 and as of July 2006 comprises 18.42% of the index[4].

The company specializes in developing and commercialization of products in three specific areas: 1) therapeutic products for cancer that inhibit telomerase; 2) pharmaceuticals that activate telomerase in tissues impacted by cell aging, injury or degenerative diseases; and 3) cell-based therapies derived from human embryonic stem cells for treatment of various chronic diseases[5].

Currently, Geron Corporation has two anti-cancer products in human clinical trials. The first, called GRN163L, is a drug that targets telomerase and has been shown to be effective in treating various cancers in animals[6]. In studies conducted at Johns Hopkins University GRN163L was active against both CD138+ and CD138neg cancer stem cells and eliminated the colony forming potential of both by five weeks. Similarly, GRN163L inhibited the in vitro clonogenic growth of CD138neg Multiple Myeloma Cancer Stem Cells isolated from the bone marrow aspirates of patients with Multiple Myeloma. Geron has started human clinical trials and is testing GRN163L in patients with lymphocytic leukemia[7]. Presently Geron is recruiting patients for six clinical trials using GRN163L, including lung cancer[8], chronic lymphocytic leukemia[9], solid tumors[10].Also in trials at Duke University is GRNVAC1, a telomerase vaccine being used on patients with prostate cancer. With the vaccine, Geron plans to inject telomerase into the patient with metastatic prostate cancer to induce the body to produce a more aggressive immune response to the cancer. This vaccine has also produced significant initial results. Geron's progress with these telomerase drugs has been significant enough to have elicited a significant monetary investment in 2005 from Merck[11].

In addition to testing drug candidates that exploit cancer cell's dependence on telomerase, Geron is researching the possible applications of activating the enzyme in normal cells to delay cellular senescence. The company is in the early stages of developing a telomerase based treatment for HIV called TAT0002 from astragalus which is actually the saponin cycloastragenol in Astragalus[12]. Geron has granted a license to to sell TA-65, the telomerase activator agent derived from the Chinese astragalus plant.

On January 23, 2009, Geron received FDA approval to begin Phase I testing of GRNOPC1 in humans [13]. GRNOPC1 is an embryonic stem cell based drug that is designed to treat spinal cord injuries. Animal tests have shown significant restoration of mobility in animals with spinal injuries that were treated with this drug [14]. Geron also has several other embryonic stem cell treatments that are still in the preclinical phase, including GRNCM1, a treatment for heart disease, and GRNIC1, a treatment for diabetes. In tests with diabetic mice, 80% of the mice given GRNIC1 were still alive in 50 days while the entire control group, which was given no treatment, perished[15].

Since it was organized in 1990 Geron has been granted over 260 patents

Geron Corporation's patents in stem cell technology

Geron Corporation initially held exclusive rights to three cell types derived from embryonic stem cells, as the result of paying for the research originally conducted by Dr. James Thomson at the University of Wisconsin-Madison.[17] The patents on the other three cell types are owned by the Wisconsin Alumni Research Foundation (WARF). WARF and Geron did not charge academics to study human stem cells but did charge commercial users. In 2001 WARF came under public pressure to widen access to human stem-cell technology, and they launched legal action against Geron Corporation to recover some of the previously sold rights. The two sides agreed that Geron would keep the rights to only three cell types.[18]

In October 2006, a legal challenge was mounted to overturn these patents by The Foundation for Taxpayer and Consumer Rights and the non-profit patent-watchdog Public Patent Foundation.[19] They contended that two of the patents granted to WARF are invalid because they cover a technique published in 1992 for which a patent had already been granted to an Australian researcher. Another part of the challenge came from the molecular biologist Jeanne Loring who stated that University of Wisconsin-Madison stem cell pioneer James Thomson's techniques (currently patents held by WARF) are rendered obvious by a 1990 paper and two textbooks.[20] The outcome of this legal challenge was particularly relevant to the Geron Corporation as it can only license patents that are upheld.[21] The patents were ultimately upheld when the reexamination concluded in 2008.[22]

As an interim measure, on January 23, 2007 WARF relaxed the stem cell patents, allowing industry-sponsored research at academic and non-profit institutions without a license.[23] WARF will allow easier and simpler cost free cell transfers among researchers and would not require a license or agreement from California's taxpayer-funded stem cell research program.[24]


  1. ^ Geron press release January 23 2009: Geron Receives FDA Clearance to Begin World's First Human Clinical Trial of Embryonic Stem Cell-Based Therapy
    ^ GERN: Profile for GERON CORP - Yahoo! Finance
    ^ The Bulletin - Philadelphia's Family Newspaper - Deja Vu All Over Again With Stem Cells
    ^ Stem Cell Stocks : companies, profiles and links
    ^ GERON
    ^ Geron Announces Data on the Effects of Its Cancer Drug, GRN163L, on Multiple Myeloma at the American Society of Hematology Annual Meeting
    ^ Safety and Dose Study of GRN163L Administered Weekly to Treat Patients With Chronic Lymphocytic Leukemia (CLL) - Full Text View -
    ^ [GRN163L]
    ^ Safety and Dose Study of GRN163L Administered Weekly to Treat Patients With Chronic Lymphocytic Leukemia (CLL)
    ^ Safety and Dose Study of GRN163L Administered Weekly to Treat Patients With Solid Tumor Malignancies
    ^ Geron plans stock offering, Merck buying $18M in shares - Silicon Valley / San Jose Business Journal:
    ^ TAT2 (cycloastragenol, CAS Registry no. 84605-18-5)
    ^ Despite Bush Veto, Stem Cell Research Abounds -
    ^ Keirstead HS, Nistor G, Bernal G, et al (May 2005). "Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury". J. Neurosci. 25 (19): 4694-705. doi:10.1523/JNEUROSCI.0311-05.2005. PMID 15888645. 
    ^ News: Geron Presents New Data That Document Progress in Development of Therapeutic Products from Human Embryonic Stem Cells. Genetic Engineering & Biotechnology News - Biotechnology from Bench to Business
    ^ Geron - Patents
    ^ The Badger Herald - WARF, Geron reach settlement
    ^ Center for Genetics and Society : How a University's Patents May Limit Stem-Cell Research
    ^ _Science_, 2006
    ^ Nature Reports Stem Cells 8 November 2007
    ^ Center for Genetics and Society : Stem Cell Patents Come Under Fire
    ^ WARF press release
    ^ > News > Business > Biotechnology - Stem cell scientists shout out hallelujah
    ^ Geron's Cloning Quandary -
    ^ BW Online | June 2, 2003 | Online Extra: Thomas Okarma: Don't Ban Stem-Cell Research
    ^ H.R. 1644, Human Cloning Prohibition Act of 2001, and H.R.____, Cloning Prohibition Act of 2001



Link to stockshark77's 1743 post regarding Geron's work with telomerase

Link to Postman's 1440 post regarding Geron's possible price per share

Link to KarinCA's 1542 post regarding Corning and Geron collaboration.

Link to Postman's 1442 post regarding GE Healthcare and Geron collaboration

Link to krays' 1545 post with CBS video regarding Geron and spinal cord injury.

Link to Postman's 1583 post with a list of clinical trials

Link to Paula's 1623 post with information regarding embryonic stem cell research


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GERN News: Amended Statement of Ownership (sc 13g/a) 08/10/2018 11:19:19 AM
GERN News: Current Report Filing (8-k) 07/31/2018 04:20:45 PM
GERN News: Quarterly Report (10-q) 07/31/2018 04:10:23 PM
GERN News: Geron Corporation Reports Second Quarter 2018 Financial Results and Recent Company Events 07/31/2018 04:07:00 PM
GERN News: Geron to Announce Second Quarter 2018 Financial Results on July 31, 2018 07/24/2018 07:30:00 AM
PlusOneCoin Top Posts
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#4948  Sticky Note For everyone concerned of the article on the Charleston 04/26/18 08:32:51 PM
#5827   Is this the start of the breakout to girlfriend 08/21/18 04:20:46 PM
#5826   Nice close, on the HOD. big bambino 08/21/18 04:19:44 PM
#5825   Boy he sure nailed me yesterday @ CVSI!!!!!! seppi08162 08/21/18 03:21:10 PM
#5824   I imagine AF has received some money in martind18 08/21/18 02:43:43 PM
#5823   Flying high now!!!! Shorty.... better get ready for that martind18 08/21/18 02:40:08 PM
#5822   The stock is showing some life today with sixpack 08/21/18 12:01:40 PM
#5821   20% in , 80% at omeros , should Dr_Thorfin 08/20/18 02:46:37 PM
#5820   Sugar: Only 17 more market days to go. big bambino 08/20/18 02:37:01 PM
#5819   Green Is Good! Please hold strong so you SH1TFORBRAINS 08/20/18 02:23:24 PM
#5818   Already in the green, its minor but its Dr_Thorfin 08/20/18 01:59:47 PM
#5817   Buyout is coming very soon,Johnson & Johnson (JNJ) Sugarshaker 08/20/18 12:31:55 PM
#5816   Congratulations you will make money here SH1TFORBRAINS 08/20/18 09:42:06 AM
#5815   Just got 10k on the dip , let Dr_Thorfin 08/20/18 09:38:50 AM
#5814   Pre-market looks encouraging. 75k right off the big bambino 08/20/18 09:29:48 AM
#5813   Time is no longer on the side of SH1TFORBRAINS 08/19/18 06:48:50 PM
#5812   TICK-TOCK, TICK-TOCK, TICK-TOCK big bambino 08/19/18 06:34:23 PM
#5811   Doc Thor, don’t cut your hair , buy SH1TFORBRAINS 08/18/18 01:30:47 PM
#5810   Looking for new investment , whats the story Dr_Thorfin 08/18/18 08:23:55 AM
#5809   Whoa. State Street added 9.2 million shares as healthywelth 08/17/18 11:58:29 PM
#5808   Need some follow thu here !!! SH1TFORBRAINS 08/17/18 07:39:56 PM
#5807   Thanks for the link. KarinCA 08/17/18 05:14:49 PM
#5806   GERN back over $4 girlfriend 08/17/18 10:23:27 AM
#5805   If it's not two months from now I'm KC01905 08/16/18 09:53:49 PM
#5804   Time will tell. ;) KarinCA 08/16/18 09:41:20 PM
#5803   2 months from now shock an awe will SH1TFORBRAINS 08/16/18 08:26:54 PM
#5802   Geron: Shifting Sands On The High Dunes subslover 08/16/18 08:09:56 AM
#5801   I think it’s got to be a mixture luisWinthorpIII 08/15/18 01:23:42 PM
#5800   This was posted today on Yahoo, In addition jeffqdhsr 08/15/18 12:53:01 PM
#5799   SCUBA leason SH1TFORBRAINS 08/15/18 12:36:57 PM
#5798   Why the price dive? zeezeeman 08/15/18 10:20:40 AM
#5797   The recent patent / patent applications IMO speak jeffqdhsr 08/14/18 12:08:17 PM
#5796   Nice steady volume... just broke $4.00 martind18 08/14/18 09:40:20 AM
#5795   Market will close GERN above 4.00 SH1TFORBRAINS 08/14/18 08:21:51 AM
#5794   Getting ready to go B O O M! I martind18 08/13/18 11:32:27 PM
#5793   New patent , one million shares AH jeffqdhsr 08/13/18 08:56:40 PM
#5792   New MTB blog on SA: StocksInvestor 08/13/18 10:13:44 AM
#5791 Greenspam3 08/13/18 05:13:17 AM
#5790   She still holds 6.56% ownership after the reduction. KarinCA 08/11/18 12:44:01 PM
#5789   Jeff: I think most important section of her big bambino 08/11/18 12:06:22 PM
#5788   At one time FMR owned 23,000,000 shares and Bandito 08/11/18 10:37:42 AM
#5787   Check out VP Debi Watson & Geron jeffqdhsr 08/11/18 10:37:33 AM
#5786   From July good read jeffqdhsr 08/11/18 10:15:43 AM
#5785   this was phot0-shopped by someone who doesn't understand bigideaportugal 08/11/18 10:11:19 AM
#5784   183million shares outstanding means A.Johnson could have never SH1TFORBRAINS 08/11/18 09:55:48 AM
#5783   Fake news it does not say she reduced holdings SH1TFORBRAINS 08/11/18 09:48:29 AM
#5782   FMR/Abigail Johnson reduced their holdings by 47%. Bandito 08/11/18 08:55:41 AM
#5781   B.B. although she’s worth 16.5 Billion , she jeffqdhsr 08/11/18 07:14:52 AM
#5780   Boy, will she take a loss if JNJ big bambino 08/11/18 12:37:40 AM
#5779   Abigail Pierrepont Johnson[3] (born December 19, 1961) is jeffqdhsr 08/10/18 11:53:20 PM
#5778 H jeffqdhsr 08/10/18 11:50:42 PM