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ENDONOVO THERAPEUTICS INC. (ENDV)

Endonovo Therapeutics (OTCQB: ENDV) is an innovative biotechnology company developing a bioelectronic approach to regenerative medicine.
Endonovo's Immunotronics™ platform is a non-invasive, non-implantable bioelectronic device for treating/preventing vital organ failure through the reduction of inflammation and necrosis, and the promotion of regeneration. Endonovo's Cytotronics™ platform provides for a method of expanding and manipulating cells using simulated microgravity and Time-Varying Electromagnetic Fields (TVEMF) for tissue engineering and cell therapies. 




***BEFORE YOU READ ANYTING ELSE ABOUT THIS AMAZING COMPANY PLEASE READ PROPHETABLES STICKY BELOW***
1. Pre-Clinical Studies To Be Completed in 2018
2. Application for IND Orphan Drug Status for its Cytotronics Product
3. Acquisition of Electroceuticals Developer, Rio Grande Neurosciences
4. 10 Form 4s filed since Dec 2016 for Insider purchases of stock
5. A "Strategic Healthcare" Institutional Investor has Ponied up $15 mil to buy back Converts
6. Company paying off the rest of its debt with $2.2 million
7. Uplistment to a "National" exchange being considered
8. Has won their injunction against Kodiak Capital and other Financiers for diluting the stock


Endonovo Therapeutics Acquires Assets of Electroceuticals Developer, Rio Grande Neurosciences, and Settles Lawsuit

 

 

Endonovo to Fund All Currently Planned and Future Clinical Trials for Traumatic Brain Injury, Post-Concussion Syndrome, Stroke and Other Central Nervous System Disorders

LOS ANGELES, CA, Dec. 26, 2017 (GLOBE NEWSWIRE) -- Endonovo Therapeutics, Inc. (OTCQB: ENDV) ("Endonovo" or the "Company"), a clinical-stage developer of non-invasive electroceuticals for the treatment of vascular diseases and inflammatory conditions, today announced it has acquired the PEMF assets of Rio Grande Neurosciences, Inc. (“RGN”) for $4.5 million and settled its lawsuit concerning RGN’s termination of the binding letter agreement to acquire RGN dated July 8, 2016.

Under the terms of the settlement agreement, RGN paid $150,000 to Endonovo Therapeutics and granted an exclusive option to Endonovo to acquire the PEMF assets of RGN for $4.5 million, which the Company exercised per the settlement agreement. The settlement has resulted in the dismissal of the case in the Superior Court of California, County of Los Angeles.

Endonovo believes settling the case at this time is in the best interest of all parties, and its acquisition of RGN's PEMF assets could result in substantial benefit to its shareholders. 

The PEMF assets includes a portfolio of intellectual property, including 27 issued patents with foreign patent protection covering the therapeutic use of PEMF for the treatment of various central nervous system disorders. Endonovo Therapeutics will initiate and fund both currently planned and all future clinical trials to evaluate the use of PEMF in the treatment of central nervous system disorders, including traumatic brain injury, post-concussion syndrome, stroke and multiple sclerosis.

The PEMF assets additionally include a portable, disposable PEMF device with a CE Mark and an FDA 510(k) clearance for the treatment of soft tissue injuries and post-surgical pain and edema in addition to medical reimbursement for the treatment of chronic wounds. Endonovo Therapeutics will begin the commercialization of the PEMF assets through licensing and joint venture agreements and the creation of various sales channels and distribution agreements.

The Company has posted an overview of the PEMF assets in the presentations page on its investor relations website.

About Traumatic Brain Injury:

Traumatic Brain Injury (TBI), also called craniocerebral trauma is a brain dysfunction caused by an outside force, usually a violent blow to the head. In 2010, approximately 2.5 million people sustained a traumatic brain injury. More than half of all brain injuries are bad enough to require people to go to the hospital. A severe TBI not only affects the quality of life of an individual and their family, but also imposes a large economic toll on society. The economic cost of TBI in 2010 was estimated to be approximately $76.5 billion. Severe brain injuries can lead to permanent brain damage or death. Half of all TBIs are from motor vehicle accidents, with military personnel in combat zones and athletes also being at risk.

About Chronic Wounds:

A chronic wound is a wound that does not heal in an orderly set of stages and in a predictable amount of time the way most wounds do. Wounds that do not heal within three months are often considered chronic. Some of the most common types of chronic wounds include, ischemic wounds, radiation poisoning wounds, surgical wounds and ulcers, such as arterial ulcers, venous ulcers, diabetic ulcers and pressure ulcers. The increasing prevalence of diabetes mellitus is a driving factor in the occurrence of chronic wounds, such as diabetic ulcers. A recent study published in Value in Health, found that approximately 15% of Medicare beneficiaries in 2014 (8.2 million) had at least one type of wound or infection at an estimated cost of nearly $32 billion to CMS. As the US Centers for Medicare and Medicaid Services (CMS) moves toward an outcome-based model, CMS needs to take a careful look at wound care, according to the authors of the study. New, more effective and equally important, more cost effective therapies are needed as the cost associated with treating these chronic wounds continues to rise.   

“We are very excited about this acquisition and the value it will provide our shareholders,” said Endonovo CEO, Alan Collier. “We are adding clinical stage programs and expanding our pipeline of non-invasive electroceuticals into central nervous system disorders, strengthening our intellectual property, and adding market-ready products for the treatment of various soft tissue injuries, post-surgical pain and swelling, as well as chronic wounds,” stated Mr. Collier.

“This acquisition represents a significant milestone for Endonovo and positions the company as the leader in bioelectronic medicine allowing for more favorable financing, uplisting the company’s common stock onto a national stock exchange and providing the company a valuation comparable to other companies in the electrical stimulation/electroceuticals sector,” concluded Mr. Collier.
 

Endonovo Receives Positive Results from Pre-Clinical Study of Non-Invasive Electroceutical

Oct 13, 2017

OTC Disclosure & News Service

-

Endonovo Receives Positive Results from Pre-Clinical Study of Non-Invasive Electroceutical

 

Non-Invasive Electroceutical Significantly Increased Cardiac Function and Reduced Ventricular Remodeling in Infarcted Animals

LOS ANGELES, CA--(Marketwired - Oct 13, 2017) -  Endonovo Therapeutics, Inc. (OTCQB: ENDV) ("Endonovo" or the "Company"), a developer of non-invasive electroceuticals for the treatment of vascular diseases and inflammatory conditions, today reported that it has completed a study to evaluate the potential efficacy of its Immunotronics™ platform, a non-invasive electroceutical, in a well-established preclinical model of heart failure (post-MI remodeling). With these positive results, the Company continues to advance the development of its pipeline of non-invasive electroceuticals targeting vascular diseases and inflammatory conditions in vital organs.

The recently completed study investigated the therapeutic efficacy of the Company's Immunotronics™ platform in a widely used mouse model of heart failure (post-MI remodeling). In this model, treatment with the Company's non-invasive electroceutical two or three times per day resulted in significantly increased cardiac function and reduced ventricular remodeling. Treatment with the Company's Immunotronics™ technology two or three times per day resulted in significantly improved Ejection Fraction (EF), Fractional Shortening (FS), Heart Weight-to-Body Weight Ratio (HW/BW), Left Ventricular Diastolic Pressure (LVDP), Left Ventricular End-Systolic Diameter (LVESD), and Interventricular Septal Dimension at Systole (IVSS). The Company will post the data for shareholders on its website shortly.

"Heart failure and vascular diseases are potential clinical targets for our non-invasive electroceuticals. These results demonstrate the incredible potential of electroceutical-based therapies," said Alan Collier, CEO of Endonovo Therapeutics. "We plan to submit our preclinical post-MI remodeling results during 2018 for presentation at a relevant scientific meeting as we continue to advance our class-leading non-invasive electroceuticals toward the clinic."

About Endonovo Therapeutics

Endonovo Therapeutics, Inc. is a leading developer of bioelectronic-applications in cell therapies and non-invasive electroceuticals. Endonovo's Immunotronics™ platform is dedicated to treating patients with life-threatening inflammatory conditions in vital organs using proprietary non-invasive electroceutical devices. The Company's non-invasive platform is based on magnetically-induced electrical field pathways that target the disruption of inflammation and cell death.

The Company's Cytotronics™ platform harnesses the bulk electrical properties of cells and tissues, namely magnetically-induced electrical field pathways to expand and enhance the therapeutic potential of cell therapies and produce next-generation biologics.



NASA STUDY

Physiological and Molecular Genetic Effects of Time-Varying Electromagnetic Fields on Human Neuronal Cells

Thomas J. Goodwin, PH.D., Lyndon B. Johnson Space Center
National Aeronautics and Space Administration (NASA), Johnson Space Center, Houston, Texas

The present investigation details the development of model systems for growing two- and three dimensional human neural progenitor (NHNP) stem cells within a culture medium facilitated by a time-varying electromagnetic field (TVEMF), i.e. PEMF.

The cells and culture medium are contained within a two- or three-dimensional culture vessel, and the electromagnetic field is emitted from an electrode or coil. These studies further provide methods to promote neural tissue regeneration by means of culturing the neural cells in either configuration. Grown in two dimensions, neuronal cells extended longitudinally, forming tissue strands extending axially along and within electrodes comprising electrically conductive channels or guides through which a time-varying electrical current was conducted.

In the three-dimensional aspect, exposure to TVEMF resulted in the development of three-dimensional aggregates, which emulated organized neural tissues.

In both experimental configurations, the proliferation rate of the TVEMF cells was 2.5 to 4.0 times the rate of the non-waveform cells. Each of the experimental setups resulted in similar molecular genetic changes regarding the growth potential of the tissues as measured by gene chip analyses, which measured more than 10,000 human genes simultaneously.

This study clearly shows the ability to use TVEMF to control the proliferative rate, directional attitude, and molecular genetic expression of normal human neural progenitor cells. The procedure is applicable to, but not limited to, the control of NHNP cells in both two-dimensional and three-dimensional culture.

The genetic responses both up-regulated and down-regulated genes which were maturation- and growth-regulatory in nature. These genes are also primarily involved in the embryogenic process.

Therefore it is reasonable to conclude that control over the embryogenic development process may be achieved via the presently demonstrated methodology. Specific genes such as human germline oligomeric matrix protein, prostaglandin endoperoxide synthase 2, early growth response protein 1, and insulin-like growth factor binding protein 3 precursor are highly up-regulated. Keratin Type II cytoskelatal 7, mytotic kinesin like protein 1, transcription factor 6 like 1, mytotic feedback 27 control protein, and cellular retinoic acid binding protein are down-regulated. Each of these two sets is only an example from the approximately 320 genes changes expressed as a consequence of exposure to TVEMF.

There is significant precedent in the literature for the results reported above. Kepler et al. (1990) reported the effects of the neurons with oscillatory properties on the composite of neural networks. This work illustrates the likelihood that a pulse width modulated system might bring on specific responses in neural tissues. As previously discussed, Valentini et al. (1993) demonstrated the ability to enhance the outgrowth of neural fibers on materials that possess a weak electric charge. This would indicate that intense electric fields are not necessarily an essential component of this process, and that a weak and persistent stimulus might yield a measurable effect.

Additional evidence of the effects of magnetic fields exists in the work of Sandyk et al. (1992a). This communication details dramatic improvement of a patient with progressive degenerative multiple sclerosis. Briefly, the patient showed considerable improvement when subjected to treatment at a frequency of 2-7 Hz and an intensity of the magnetic field of 7.5 pico Tesla. These parameters marginally parallel those of this report. In a similar fashion, Sandyk et al. (1992b) reported significant improvement in patients treated with the same field strength and intensity. The ability to suppress or stimulate the growth of non-excitable cells has been reported in mouse lymphoma cells by Lyte et al. (1991). A narrow range of electric field was found to be effective at one end to stimulate and at the other to inhibit the growth of these cells. These data might suggest cellular receptors in all cells. To sustain this notion, Brüstle et al. (1996) reported the potential to use neural progenitors for recapitulation of neural tissues. As would be expected, this would require genetic control at the embryonic level. We believe this study indicates our ability to trigger these parametric events.

As is clearly demonstrated in the human body, the bioelectric, biochemical process of electrical nerve stimulation is a documented reality. The present investigation demonstrates that a similar phenomenon can be potentiated in a synthetic atmosphere, i.e., two-dimensionally or in rotating wall cell culture vessels.

One may use this electrical potentiation for a number of purposes, including developing tissues for transplantation, repairing traumatized tissues, and moderating some neurodegenerative diseases and perhaps controlling the degeneration of tissue as might be effected in a bioelectric stasis field.


History

The basis for Endonovo’s Time-Varying Electromagnetic Field (TVEMF) technology was created at NASA in conjunction with the development of cell therapies to treat injuries and diseases that astronauts might encounter during long term manned missions in outer space.

The original concept of TVEMF was developed when NASA realized that cellular growth  increased as the space shuttle crossed the earth’s magnetic poles. It took over eight years to define and develop a device that produced the same effect. This magnetic field device (TVEMF) was originally designed to enhance cellular expansion (growth) in NASA’s rotating wall bioreactor. After numerous experimental studies, the results were so significant with the bioreactor that a prototype was designed for use directly on the human body.
 

Moving Beyond the Petri Dish

Cells grown in Petri dishes cannot form complex 3D tissues because they tend to sink within their growth mediums. This posed a limitation on researchers studying how tissues form inside the body.

In the 1970’s, a small group at NASA’s Johnson Space Center (JSC) began to think about outer space as a possible answer. Researchers at JSC theorized that if cells could be grown without the influence of the earth’s gravity, they would not sink to the bottom of the culture container; rather, they would stay suspended in the medium and therefore might assemble and form tissue that more closely resembles tissue in the body.



 

NASA Bioreactor Simulates Microgravity on Earth

NASA researchers developed a soup can-sized bioreactor that spun on its side, preventing cells from sinking to the bottom by maintaining a continuously free-falling state through the culture media. The bioreactor was able to simulate microgravity on earth, providing researchers with the ability to study how tissues form in the body three-dimensionally. The original goal was to attempt tissue growth on Space Shuttle missions. However, the Challenger disaster in 1986 resulted in the grounding of NASA’s space fleet. Subsequently, NASA researchers switched their efforts to creating a culturing device that simulated some aspects of microgravity on earth.


 

Experiments in Outer Space

NASA researchers conducted multiple experiments using the bioreactor aboard STS-70, STS-85 and STS-90.

During STS-70 in 1995, researchers tested the performance of the bioreactor in microgravity using colon cancer cells. The cells were able to aggregate and form masses 10 mm in diameter. These masses were 30 times the volume of those grown in the control experiment on the ground.
During STS-85 in 1997, researchers repeated the experiment using colon cancer cells and again, mature, differentiated tissue samples were grown. This confirmed previous results – microgravity is an environment beneficial to cell culture and tissue growth.
During STS-90 in 1998, human renal tubular cells were cultured in the bioreactor for 6 days. Researchers compared the activity of 10,000 genes in the flight and ground cultures and identified several of the control genes for differentiation and three-dimensional tissue formation.

 


Earth’s Magnetic Field Influences Cell Growth

Early on, as NASA researchers analyzed data from their experiments aboard the Space Shuttle, they discovered that cells were growing at an increased rate when passing over the earth’s magnetic poles; suggesting that the earth’s magnetic field was influencing cell growth.

Additionally, several growth factors and cytokines were upregulated in the bioreactor during cellular expansions.


 

NASA Researchers Add Pulsed Electromagnetic Fields to Bioreactor

Initially, NASA researchers could not replicate the cell growth achieved aboard the Space Shuttle. NASA was using basic sine waves, which could not produce the same effect.

Over the subsequent eight years, researchers experimented with multiple waveforms, frequencies, and slew rates and found the square waveform was able to help deliver the required results and allowed NASA to identify the exact magnetic field format that increased cell growth 400% and upregulated over 200 growth factors and cytokines (G-CSF, GM-CSF, IL-2) in the rotating wall bioreactor.

It was determined that a square waveform with a low frequency (5-10 Hz) and a very rapid slew rate provided optimized results for cellular expansion.


 

Shifting Away from Stem Cell Transplants

After achieving astounding results with the TVEMF-bioreactor, NASA researchers began to explore whether the effects of TVEMF on cell growth and growth factor production could be done inside the body.

The basic idea was to create a device that could stimulate the body to mobilize and expand stem cells and then promote their homing to the sites of injury without having to extract stem cells from patients, expand the stem cells in vitro and then re-inject the expanded stem cells into the patient for the treatment.

The goal of the TVEMF device is to mitigate many of the problems that current stem cell treatments face, such as the use of drugs to mobilize stem cells and the use of external growth factors and genetic manipulation for stem cell expansion.

 

Rabbit Osteotomy Study

This is work conducted at Texas A&M University College of Veterinary Medicine on New Zealand White Rabbits using TVEMF.

An osteotomy was performed on the ulna (forearm) leaving a significant gap that would not heal under normal conditions.

The control group used “sham” TVEMF over the area of the osteotomy and the treatment group used TVEMF stimulation.

The study was not conducted until full healing had occurred, but there were obvious differences between the control group and the treatment group.

The study was actually discontinued because researchers could easily distinguish the difference between the control group and treatment group animals. The treatment group animals were mobile, while the control group animals were immobile.

Photo of the incision: Notice the significant gap in the bone


















After 14 days with sham TVEMF stimulation:
No bone growth – notice the gap



After 14 days with TVEMF stimulation:
Already some bone growth



After 28 days with sham TVEMF stimulation:
Still no bone growth – notice the gap



After 28 days with TVEMF stimulation:
Dramatic increase in bone growth



 

Nude Mouse Study

The “nude mouse” study was performed by the independent firm, Charles Rivers Laboratories Inc. using athymic mice. The lack of a thymus leaves the mice without the ability to mount most types of immune responses.

The purpose of the study was to determine whether a cell line was tumorigenic when injected by the subcutaneous route into athymic nude mice.

TVEMF-expanded stem cells were injected into athymic nude mice. It was determined that the TVEMF-expanded stem cells caused no tumors in the mice within 85 days of the injection of the TVEMF-expanded stem cells.

The study validated that expanded stem cells could be transplanted without harmful effects that have been demonstrated with genetic modification.

 

mFISH Study


 

The multicolor fluorescence in situ hybridization “mFISH” study was conducted at NASA’s Johnson Space Center to determine whether TVEMF technology caused chromosomal damage to stem cells expanded using the NASA technology.

The mFISH study found that there was no chromosomal damage or change in the expanded adult stem cells 90 days after their expansion.

The presence of chromosomal damage or change could cause a wide array of problems such as tumor formation.

The study verified that stem cells grown in the NASA bioreactor are safer for potential therapies than current methods that use genetic manipulation.

 

Bioelectronics

Electromagnetic pulses are responsible for many of the activities in our bodies. They are an integral part of what keeps our hearts beating and brains functioning.

The bioelectronics device is a portable Time-Varying Electromagnetic Field (TVEMF) system. The unit uses a sophisticated miniaturized circuit board that delivers the specifically designed and patented electromagnetic field to a designated area of the body through the use of antennas (coils).

 

TVEMF vs PEMF

Time-Varying Electromagnetic Field (TVEMF) technology is fundamentally different from other magnetic pulse devices. TVEMF is based on the physics of electricity and magnetism as well as the physiology of cells and tissues.

 

  • PEMF devices do not produce square waves, the optimal waveform for a tissue response.
    PEMF devices do not produce enough intensity to stimulate a response; most do not even produce 1 Gauss of intensity.
    PEMF devices do not produce a rate of induction (slew rate) that is quick enough to penetrate deep within tissues. TVEMF produces pulses that are only 0.0001 seconds wide.
    Furthermore, TVEMF features repeating patterns of pulses that are selected based on known motor-neuron stimulation patterns of musculoskeletal tissues.
     

Why Square Waves?

 
Sine waves take too long to reach their peak intensity. The lower slew rate means that they are not effective in producing a cellular/tissue response.

Triangle and sawtooth waves also suffer from a lower slew rate, meaning that they are not effective in producing a cellular/tissue response.

Endonovo’s TVEMF device produces a patented square waveform, which was proven the most effective waveform to increase cell growth and the production of over 200 growth factors and cytokines.

 

Cytotronics™ Platform

Our Cytotronics™ platform uses Time-Varying Electromagnetic Field (TVEMF) technology to expand and enhance the therapeutic properties of stem cells, immune cells and for use in tissue engineering. The goal of our Cytotronics™ platform is to create optimized cell-based therapies with greater therapeutic potential than the un-modulated cells currently being used in regenerative medicine.

The origins of our Cytotronics™ platform dates back to experiments conducted at NASA to expand stem cells ex vivo and to create therapies that could be used to treat astronauts during long term space exploration. The results of those experiments revealed that Time-Varying Electromagnetic Fields (TVEMF) could be used to expand stem cells in the lab and resulted in the increased expression of dozens of genes related to cell growth, tumor suppression, cell adhesion and extracellular matrix production.

A Physics Approach to Biology – Ex Vivo Modulation

We have built upon over 15 years of research and development to create a novel therapeutic paradigm – the systematic enhancement of the biological and therapeutic properties of cells ex vivo. This allows for the creation of a precise, scalable and cost effective approach to maximize the safety and effectiveness of cell-based therapies.

While our competitors are using genetic modification and pharmacological modulation to alter and enhance the biological properties of cells, we are taking A Physics Approach to Biology™ in the use of bioelectronics to create ex vivo modulated cells with enhanced biological and therapeutic properties. Using our Cytotronics™ platform, we are able to create cells that express higher levels of key genes related to stem cell maintenance, cell growth, cell homing and engraftment. Cytotronic™ expansion of peripheral blood stem cells resulted in an over 80-fold expansion of CD34+ cells in as few as 6 days.

Our Cytotronic™ platform was shown to be able to maintain normal human neural progenitor (NHNP) cells in long term culture (180 days), undifferentiated with the ability to be cryogenically preserved then subsequently reintroduced into culture with stem and progenitor markers still intact. NHNP cells that were expanded using our technology were then shown to not be tumorigenic when introduced into nude (athymic) mice for 85 days. Multi-color Fluorescence In Situ Hybridization (mFISH) showed that there was no chromosomal damage to cells subjected to Time-Varying Electromagnetic Fields (TVEMF).

Perivascular Cell Therapy Created Using Cytotronics™

Each year, an estimated 60,000 patients with leukemia and lymphoma need bone marrow transplantation. However, only 25,000 of those patients actually receive a transplant, primarily because the other 35,000 patients are unable to find a fully matched bone marrow donor.

Umbilical cord blood from newborn children is an excellent source of hematopoietic stem cells for stem cell transplants because their immune system is still immature and the stem cells have a lower probability of inducing an adverse immune response in patients. Furthermore, a perfect immunological match between donor and recipient is not necessary, unlike in bone marrow transplants.

However, in most cases a unit of umbilical cord blood contains too few stem cells to treat an adult patient and its use is confined above all to the treatment of children. Numerous patients have better matched cord blood products available (5/6 or 6/6 HLA match), however those products have low cell doses and are not suitable for use in adult patients. This is one of the reasons why less than 3 percent of cord blood collected in the United States is ever used. Low volume cord blood units present the opportunity to expand and/or enhance these unused cord blood units for the widespread use of hematopoietic stem cells in regenerative medicine.

Off-The-Shelf Therapeutic

Our Perivascular Cell Therapy is created using immunologically privileged and immune-modulating stem cells from a portion of the human umbilical cord and co-cultured with adipose-derived stem cells along with cord blood cells to create a perivascular cell mixture that can be used to treat malignant and non-malignant hematological disorders.

Endonovo’s cell therapy is an off-the-shelf therapeutic that can be stored indefinitely in a low temperature freeze without requiring cryopreservation. Our technologies are particularly suited to expand the use and effectiveness of low-volume cord blood units.

More In Vivo-Like Stem Cells

Our off-the-shelf therapeutic is created in a three-dimensional bioreactor using our proprietary Cytotronics™ platform to further expand and enhance the biological properties of the stem cells within the perivascular cell mixture. Our use of a perivascular co-culture in a three-dimensional bioreactor is meant to mimic the way that blood-forming stem cells renew and reside in the body. This simulated stem cell niche allows for the expansion of long-term self-renewing stem cells. Researchers had previously identified endothelial and perivascular cells as the cells that were functionally responsible for the maintenance of blood-forming stem cells (HSCs) in the body. Our technologies provide a method for the expansion of HSCs in an environment that resembles their native stem cell niche.
 



Endonovo is using a three-dimensional bioreactor that allows for the large-scale expansion of blood-forming stem cells that enhances cell-to-cell contact between perivascular cells and HSCs, providing a culture method that more closely resembles the stem cell niche. As seen below, (A) cells grown in three-dimensions become more spherical that those grown in (B) static two-dimensional cultures. Cells grown two dimensionally in Petri dishes or t-flasks sink within their growth medium. These cells do not look or function like real human cells, which grow three-dimensionally in the body.



 

Management

Alan Collier – Chairman & Chief Executive Officer

Mr. Collier has more than twenty years of experience in corporate finance, IP development, telecommunications and technology with a concentration in healthcare and technology over the last five years. Prior to his appointment as Endonovo’s CEO and chairman, Mr. Collier served as CEO and director of IP Resources International, Inc. where he was instrumental in developing a platform for for the licensing and acquisition of life science and technology companies.

Previously, Mr. Collier served as a Senior Managing Director at Mid-Market Securities, a FINRA-registered Broker-Dealer. Prior to joining Mid-Market Securities, Mr. Collier was a Managing Director at Mosaic capital and co-managed its Capital Markets Group. He was previously a Vice President at Corporate Capital Group and Managing Director and CEO of Greenbridge Capital Group.

Over the progression of his career, he has specialized in the development and financing of early stage, high growth, and acquisitive companies (public and private). He has structured, participated in, and completed numerous transactions including mergers and acquisitions, equity and debt placements, capital restructuring, joint venture development, and channel partner procurement. He has held numerous board and executive positions throughout his career in the telecommunications, technology, specialty finance, corporate finance and healthcare industries. Mr. Collier holds FINRA Series 7, 79, 63, and 24 Licenses.

Michael Scott Mann – President
Mr. Mann has over 30 years experience in merger and acquisitions and operational management. In 2008 Mr. Mann acquired the assets of Hanover Asset Management, now Endonovo Therapeutics, Inc,. and led the company to become listed on the OTCBB in 2012.

From January 2003 to April, 2011, Mr. Mann was the Founder, President and Chief Executive Officer of U.S. Debt Settlement, Inc. (USDS), a Frankfurt listed company, where he implemented a growth by acquisition strategy successfully acquiring numerous companies.

From January 2002 to July 2003, Mr. Mann was the Chief Executive Officer of Shared Vision Capital, a boutique investment banking firm that assisted emerging companies with early seed capital and bridge loans. Earlier still, from October 1998 to December 2001, Mr. Mann was the Vice President of Investor Relations for JuriSearch.com, an online legal research platform. During his tenure with JuriSearch.com, Mr. Mann was directly responsible for funding the company’s growth and development. In addition, Mr. Mann founded Universal Pacific Communications, a privately owned telecommunications company. Under his leadership as President, Universal Pacific developed a fiber optic disaster recovery telecommunications network, designed for and successfully marketed to Fortune 1000 companies.

Leonard Makowka, M.D., Ph.D. – Chief Medical Officer

Over the past 30 years, Dr. Makowka has transitioned himself as a distinguished clinical and transplantation surgeon and medical researcher to a successful entrepreneur, advisor and board member in a wide range of industries. Since receiving his M.D. degree from the University of Toronto Medical School in 1977 and Ph.D. from the University of Toronto’s Department of Pathology in 1982, he has published over 400 articles and chapters in both clinical and basic scientific research.

Between 1989 and 1995, Dr. Makowka served as the Chairman of the Department of Surgery and Director of Transplantation Services at Cedars Sinai Medical Center in Los Angeles, California. During this time, he also served as Professor of Surgery at the UCLA School of Medicine. Dr. Makowka would later become Executive Director of the Comprehensive Liver Disease Center at St. Vincent’s Medical Center in Los Angeles, CA, where he created a multiple disciplinary approach to the treatment of liver disease.  He is currently the active Chairman of the Corporate Advisory Board of the UCLA School of Nursing. Dr. Makowka has since retired from the active practice of medicine and has experienced a successful career in developing investment and business strategies for companies in the healthcare, life sciences, finance, and other industries.

Dr. Makowka has served on the board of directors for various private and publicly traded companies in the healthcare and life science industries. From 1998 to 2003 he served on the Board of Directors of Hollis Eden Pharmaceuticals, (NASDAQ: HEPH) and served on the Board of Directors for Kinmed, Inc., a privately held biotech company. As an entrepreneur, Dr. Makowka has worked with several companies in a wide range of industries. He was a founding consultant for Ivivi Technologies, Inc. (NASDAQ: IVVI), a publicly traded medical technology company focusing on designing, developing, and commercializing proprietary electrotherapeutic technologies. In addition, Dr. Makowka founded Trillenium Medical Imaging Inc., a company engaged in the novel healthcare application of proprietary infrared imaging.

As Endonovo Therapeutics’ Chief Medical Officer, Dr. Makowka will be responsible for developing the company’s scientific advisory board, overseeing the company’s clinical research activities and will serve as a liaison between the company and the medical community.

Donnie Rudd, Ph.D., D.Sc., D.D., J.D. – Chief Scientist & Director of Intellectual Property

Dr. Rudd began his career as a Chemical Engineer after graduating with a B. S. degree in Chemical Engineering from Texas A&M. His career then progressed into work as a successful Patent Attorney after obtaining his J.D. degree from Chicago-Kent College of Law. Over the course of 15 years of litigating cases as one of the principals of Rudd & Associates., he was admitted to over 14 courts and taught at 3 universities. Dr. Rudd has written 17 books and over 140 publications.

After a successful tenure and being recognized as “One of the top 5 attorneys in the United States”, he earned his Ph.D. in Bioscience and shifted his focus to stem cell and electromagnetic therapy research.

He joined Regenetech, Inc. in April 2002 as CEO and Corporate Secretary. In 2002 he became its Chief Scientist and Director of Intellectual Property. With patented licensing rights through an innovation from NASA, he lead in the research on the NASA licensed bioreactor. Subsequently, NASA researchers under Dr. Rudd’s guidance added TVEMF technology to the bioreactor. He has developed over 100 different patents and inventions focused on stem cell technology. In accordance with his patents and groundbreaking discoveries in stem cell research, he has become a NASA recognized inventor. For his patent and inventive work during his time at Regenetech, Inc., Dr. Rudd’s work received recognition from the Space Foundation after they inducted the Commercial Earth-Imaging Satellite and Intrifuge CellXpansion technology into the Space Technology Hall of Fame.

 



Investor Relations Contact:
Endonovo Therapeutics, Inc.
Mr. Steven Barnes
Vice President of Investor Relations
(800) 701-1223, Ext. 108
Sbarnes@endonovo.com
www.endonovo.com
 
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#28071  Sticky Note Endonovo Therapeutics, Inc. (ENDV) Reports First Patient Enrollment rockman213 06/14/18 10:17:35 AM
#27949  Sticky Note Current State of Affairs with Endonovo Craig305 06/06/18 11:28:00 PM
#26891  Sticky Note Endonovo Therapeutics Signs Distribution Agreement with Plagens Medical brojazzy 05/09/18 09:16:10 PM
#21001  Sticky Note Here is a breakdown in layman terms of Biotech_Tradez 10/15/17 02:34:31 PM
#14181  Sticky Note Daily and Weekly Charts The_Free_Nebula 06/08/17 07:52:58 AM
#28195   You are correct. This is a huge waiting Craig305 06/21/18 08:58:49 PM
#28194   That 10k was for you buddy... don’t say pizzler1218 06/21/18 02:26:26 PM
#28193   I feel like many shareholders here are our brand0nnn 06/21/18 02:22:47 PM
#28192   Such pathetic ass buy volume here, once again brojazzy 06/21/18 02:00:36 PM
#28191   Compensation Disclosures: ACR Communications LLC. which is the company money2013 06/21/18 10:09:47 AM
#28190   https://finance.yahoo.com/news/biotech-company-endv-everyones-watchlist-14000066 money2013 06/21/18 10:07:48 AM
#28189   What article are you referring to? CMohnR 06/21/18 10:06:30 AM
#28188   ENDV paid $59,000 for the article. Nothing wrong money2013 06/20/18 11:30:59 PM
#28187   Mann had the last buy on the Ask Craig305 06/20/18 04:22:42 PM
#28186   Biotech Company, ENDV Should Be On Everyone's Watchlist brojazzy 06/20/18 02:21:44 PM
#28185   Very very nice twit #Biotech Company, $ENDV Should Be Las3r 06/20/18 02:19:00 PM
#28184   Yes sir, I noticed the exact same thing! brojazzy 06/20/18 01:01:14 PM
#28183   Maybe this is a hint they have submitted Craig305 06/20/18 12:56:55 PM
#28182   I also see they want some shares above Craig305 06/20/18 12:51:55 PM
#28181   Whenever the bid gets tight there's ALWAYS someone brojazzy 06/20/18 12:44:38 PM
#28180   Nice that they are posting stuff, keep it Las3r 06/20/18 11:50:02 AM
#28179   A way around #opioids: Target the type of Las3r 06/20/18 11:48:05 AM
#28178   Nice twits from Endv The growing case against IV Las3r 06/20/18 11:46:42 AM
#28177   Hopefully I'm not jinxing it, but no he's brojazzy 06/20/18 11:16:02 AM
#28176   Gotta ignore the kids, where is ARCA? pizzler1218 06/20/18 10:16:46 AM
#28175   The "cheerleading"....Where is it? I don't see anyone brojazzy 06/20/18 09:52:37 AM
#28173   ARCA back on the ASK, he's got endless brojazzy 06/20/18 09:43:33 AM
#28172   I guess Mann is buying as usual, just Las3r 06/19/18 11:21:12 PM
#28169   If mann is still buying there are still vp_007_99 06/19/18 05:07:49 PM
#28168   Form 4 Update There was no purchase from Mann Craig305 06/19/18 04:42:07 PM
#28167   I cordially invite them for a play date Lo$eitall80 06/19/18 07:15:24 AM
#28166   MAXM was the one buying at the end pizzler1218 06/18/18 09:54:38 PM
#28165   I was not paying attention to L2 at Craig305 06/18/18 09:53:36 PM
#28163   I enjoy reading your posts here. You are PencilNeckGeek 06/18/18 08:46:31 PM
#28162   In the last two minutes of trading, shares rbd1 06/18/18 04:49:12 PM
#28161   Hmmmmm MAXM on the BID pizzler1218 06/18/18 03:59:02 PM
#28160   Ok thanks for the explanation but it still carp302 06/18/18 01:13:33 PM
#28159   You beat me to it you SOB! pizzler1218 06/18/18 01:10:45 PM
#28157   How about the fact that expanding the label Biotech_Tradez 06/18/18 01:07:54 PM
#28156   You said in April, you were invested in Craig305 06/18/18 01:07:35 PM
#28155   So why aren’t they trying to expand sofpulse Doyle McBoyle1 06/18/18 12:56:03 PM
#28154   Stop me if I’m wrong, but I feel Doyle McBoyle1 06/18/18 12:51:01 PM
#28153   It is cleared for a limited indication: post-surgical Biotech_Tradez 06/18/18 12:43:08 PM
#28152   I can't explain it either. If they have carp302 06/18/18 12:15:28 PM
#28151   Amazing* Doyle McBoyle1 06/18/18 11:19:16 AM
#28150   And idk who posted it but if we Doyle McBoyle1 06/18/18 11:18:56 AM
#28149   Funny cause sales revenue= increase in SP but Doyle McBoyle1 06/18/18 11:17:47 AM
#28148   This is good, what’s next? Will it be Las3r 06/18/18 09:47:32 AM
#28147   If they can grow hair for real they carp302 06/18/18 06:22:41 AM
#28146   Everyone should take a look at this application. Craig305 06/17/18 10:23:49 PM
#28145   Was doing some research on the RGN patent Craig305 06/17/18 09:35:10 PM
#28144   You have a great weekend too, Carp! brojazzy 06/15/18 05:36:36 PM
#28143   Looks like medical devices are getting pulled into CMohnR 06/15/18 05:04:11 PM
#28142   Nice finish. Have a good weekend everyone. carp302 06/15/18 04:12:12 PM
#28141   So all those shares of ARCA's were bought brojazzy 06/15/18 02:50:16 PM
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