CLR 131 is a small-molecule, targeted PDC designed to deliver cytotoxic radiation directly and selectively to cancer cells. CLR 131 is our lead therapeutic PDC product candidate and is currently being evaluated in multiple Phase 2 and Phase 1 clinical studies.
CLR 1700 series is an internally developed PDC program leveraging a unique warhead targeting Burton tyrosine kinase (BTK) and designed to treat a broad range of hematologic cancers. The warhead provides further specificity by targeting the BTK pathway, which is upregulated in hematologic cancers versus in comparison to normal tissue. We believe that this additional level of targeting will allow us to provide a new drug candidate that has the ability to significantly improve patient outcomes. Leveraging our iterative discovery and screening process, we have been able to rapidly accelerate the development of this program. Currently marketed BTK inhibitors generate >$4B in revenues per year.
CLR 1900 series is another internally developed proprietary PDC program leveraging a novel class of small molecule cytotoxic compounds as the warhead. The warhead functions by targeting a validated pathway that results in the inhibition of cell division and thereby killing the tumor cells. This series of molecules could produce a product candidate targeted to select solid tumors. Currently, the program is in early preclinical development.
CLR 1800 series is part of a collaborative PDC program with Pierre Fabre, the third largest French pharmaceutical company with an extensive oncology research and development infrastructure. The objective of the research collaboration is to design a library of PDCs employing Pierre Fabre's chemotherapeutics in combination with our proprietary cancer-targeting delivery vehicle. The newly developed PDCs may provide enhanced therapeutic indices to otherwise highly potent, non-targeted warheads through the targeted delivery to cancer cells. Significant progress has been achieved and the program continues to rapidly advance with a number of PDC molecules showing enhanced pharmacologic behavior over the parent compound alone.
CLR 2000 series is part of a collaborative PDC program with Avicenna Oncology, a leading developer of antibody drug conjugates (ADCs). The objective of the research collaboration is to design and develop a series of PDCs utilizing Avicenna Oncology’s proprietary cytotoxic warhead. Although Avicenna Oncology is a leading developer of ADCs, this collaboration was sought as a means to overcome many of the challenges associated with ADCs, including those associated with the targeting of specific cell surface epitopes.
CLR 2100 and 2200
CLR 2100 and 2200 series are part of a collaborative PDC programs with Onconova Therapeutics, Inc., a biotechnology company specializing in the discovery and development of novel small molecule cancer therapies. The collaboration is structured such that we will design and develop a series of PDCs utilizing different small molecules that Onconova Therapeutics is developing as the warheads with the intent to show improved targeting and specificity to the tumor. Onconova Therapeutics has previously taken at least one of the molecules into Phase 1 clinical trials.