Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Great Idea........one day $BIXT will be famous for curing these viruses..........
Z
This situation with the emerging Bird Flu epidemic is reminiscent of the Mad Cow disaster which was triggered by feeding bovines ground up cattle meat and bone meal containing self-propagating prions--just as God intended, eh?
What if $BIXT 's antiviral is used with Ifus cattle feed to stop bird flu?
https://www.telegraph.co.uk/global-health/science-and-disease/chicken-waste-fed-to-cattle-may-be-behind-bird-flu-outbreak/
The Telegraph
Ground-up chicken waste fed to cattle may be behind bird flu outbre...
Experts warn that lax regulations could also see the virus spread to US pig farms, with serious consequences for human health
[10:36 PM]
Fears are growing that the H5N1 outbreak among cattle in the United States could have been caused by contaminated animal feed.
In contrast to Britain and Europe, American farmers are still allowed to feed cattle and other farm animals ground-up waste from other animals including birds.
Dairy cows across six US states – and at least one farm worker – have become infected with the highly pathogenic virus, which has already killed millions of animals across the globe since 2021.
The farm worker, who is thought to have been exposed via infected cattle in Texas, is only the second recorded human H5N1 case in the US. Since February, the US has investigated and discounted a further 8,000 possible exposures, according to Dr Joshua Mott, WHO senior advisor on influenza.
The development is of concern because it allows the virus, which has killed millions of birds and wild mammals around the world, more opportunities to mutate.
[10:39 PM]
Experts fear that H5N1, which was only first detected in cows a few weeks ago, may have been transmitted through a type of cattle feed called “poultry litter” – a mix of poultry excreta, spilled feed, feathers, and other waste scraped from the floors of industrial chicken and turkey production plants.
In the UK and EU, feeding cows proteins from other animals has been tightly regulated since the outbreak of BSE – or ‘mad cow disease’ – 30 years ago.
Experts are unsure but fear it could be the poultry litter feed used in the US that has passed the virus to cattle.
“In the US, the feeding of poultry litter to beef cows is a known factor in the cause of botulism in cattle, and is a risk in the case of H5N1,” said Dr Steve Van Winden, Associate Professor in Population Medicine at the Royal Veterinary College.
Dr Tom Peacock, a virologist and fellow at the Pirbright Institute agreed: “This latest case wouldn’t be the first time there have been concerns H5N1 could be moving through different mammals via contaminated feed,” citing the outbreak of avian flu in cats in Poland last year, which experts suspected might have been transmitted through mink byproducts used in raw cat food.
The US cattle industry is worth over $100 billion and regulations covering animal standards there have long been controversial in Europe – most famously over the use of hormones in the rearing of cattle for meat.
[10:40 PM]
Although the presence of H5N1 in US cattle herds increases the risk of the virus getting into humans via farm workers, it is the spread of the virus to pig farms that presents the bigger threat.
This is because pigs have receptors on some cells that are similar to humans, making it much more likely that the virus could mutate and jump to humans if pig farms become infected.
So far, the virus hasn’t shown any signs of worrying mutation, however.
“Infection of H5N1 in pigs is of particular concern – they are highly susceptible to human influenza virus strains so could act as mixing vessels for avian and human viruses to mix and generate viruses that can more efficiently infect humans,” said Dr Tom Peacock.
Poultry litter is not only cheaper than other food sources like soy and grains but is also more calorie-dense, meaning farmers can bulk up their herds much more quickly.
Great read. I bought some galt today as well.
https://www.insiderfinancial.com/post/galectin-therapeutics-galt-a-discount-opportunity-moving-on-analysts-upgrade
BIXT gets great reviews here
BIG RIG
Basically it's saying that $BIXT has a cure for the Common Cold.......doesn't get any bigger than that........
Z
Yup: broad spectrum antiviral capable of neutralizing a number of viruses capable of upper respiratory tract infections. We are advancing the field of Glycovirology and working toward bringing to market the potential first broad spectrum antiviral capable of neutralizing a number of viruses without changing the formulation and theoretically resistant to viral mutations. Says a lot.
$BIXT
Perhaps a few of us here can help with that if our other investments would just cooperate and bloom MASSIVELY...Sigh...
You're more than welcome.......hope you join our team.........
Z
thanks for he info dear one
Science takes a step into the future!
https://www.zerohedge.com/news/2024-03-11/terminating-viral-threat-artificial-intelligence-myth-or-reality
I think the question comes down to whether you want 100% of nothing maybe 100% of something five years from now or a smaller percentage next year!
I hope that is what they will do.
Financing is not the answer! Partnering is the only thing that makes sense. Let them spend their money for percent of ownership.
finding a suitor rather than dilute it into the ground
What’s the hold up for funding?
yes they need funding for phase 3 they get that its full on
Sort of like an NFL quarterback with multiple pre-snap reads who can't make up his mind which direction to head in(?). If we can just secure enough financial backing to get these projects off the ground perhaps we'll be the darling of Wall Street someday? Or is it something else?
With that patent pending, this company can go in 60 different directions. I was expecting the next PR to be something about the COVID trials. Instead, it was on herpes zoster (shingles). Shows that this company has a lot of directions it can go and multiple drug possibilities in the pipeline. I had shingles once and it was a painful 7 weeks of very little sleep with the medication I was prescribed not helping much. If this drug actually works and patients get relief in 3-4 days....... they call it a game-changer.
yes Im shocked they havent gotten a deal yet with all these possibilities
Exciting news... hopefully the first of many more to follow. This company and their research has pretty exciting potential.
With an average volume of 62,701 shares over 30 days, $BIXT maintains steady trading activity, reflecting investor confidence in their innovative solutions for hypoxia and viral diseases.
You make a good point about the number of pills. Patients don't like taking a lot of pills or large ones so the dose optimization study is important for general use and adoption. Health care providers shy away from prescribing medications where patients complain about the size of the pills or how many or how often one needs to take them. Once a day and a small, easy to swallow pill is ideal. But a company can control that property to a certain extent by making the pills more or less potent and larger or smaller by adjusting the inert, carrier materials in the pill as the trial outcome dictates. The best we can hope for on this trial is that a small pill taken once a day for a short period of time is effective at eradicating the virus from the body. If that happens, BIXT is sitting on a gold mine!
I’m very confident that the dose study will be a reduction in the number of tablets required to effectively cure the virus!
$BIXT has ranged from $0.071 to $1.05 over the past 52 weeks, reflecting fluctuations in investor sentiment and market dynamics. With an average volume of 74,292 shares over the last 30 days, it remains actively traded.
Bioxytran's ( $BIXT ) previous price of $0.117 signifies ongoing market interest and potential developments in their hypoxia and viral disease treatment initiatives.
So, if the big dogs some day feel threatened by this newcomer, wouldn’t one of them just make a nice offer to acquire the company?
Nice post...........Kudos..............
Z
"Does it cure the common cold?" I have some experience in medicine for 30 years but no expert on this. It seems to me that it boils down to whether the virus in question (in this case, the common cold viruses) have a galectin fold. There are about 300 viruses estimated to cause "the common cold." Many are in the rhinovirus class but there are some colds caused by coronaviruses (not the SARS recent Covid virus). Thus you get mild colds and "bad colds" depending upon the type of virus you caught. Read this section of the PR carefully:
"“We used Nuclear Magnetic Resonance imaging to engineer / optimize a carbohydrate structure ideally suited to neutralize the spike protein of the SARS-CoV-2 virus. Before this discovery, neutralizing antibodies were only able to target the tip of the spike proteins of viruses which rapidly mutate, but after this discovery we found out that carbohydrates are able to neutralize viruses by binding to the galectin fold. The galectin fold represents a conserved structure on the spike protein virtually incapable of mutation, therefore it opens up a whole new field of research in Glycovirology. We believe a large number of viruses contain this galectin binding region on their spike proteins offering a widely druggable target that could be easily tested in a lab setting."
So the key is, does the common cold have a galectin fold? But the part I like the most about this new drug is the "galectin fold is virtually incapable of mutation" part. That means no chasing a new virus mutation every time you turn around with a different drug. If this ProLectin-M drug does what they say it does, big Pharma is NOT going to be happy. It will neutralize (no pun intended) a lot of drugs out there (Paxlovid, monoclonal antibody treatments, etc.) and big Pharma will lose a lot money if this drug works. A big IF for sure. But also keep in mind as some on here have alluded to, these drug trials take a LONG time to do and if you have no patience or don't have a long investment horizon, you are in the wrong place. The FDA has a way of stringing these things out with requests for this, that and the other thing during the trials. "Oh, this patient got shingles while they were on the trial? Oh, maybe the drug caused that. No? Prove it, etc." I've seen it happen and further I was part of one of those trials collecting data for the approval process...... My thoughts FWIW
News out this morning that BIXT is starting the dosing Optimization phase for the Phase III trial.
Longer it sits here the more I can load up. Tire kickers and waiters can pay more and chase when antivirals are approved for up 60+ viruses.
Hope they do before 2035. I mean this one has been trickling down for weeks. And pretty much since they got 500k from the university hedge fund
If it drops further I might add more but wow this hasn’t been a good investment even for insiders!
So far............but things will change.............
Z
Not enough people realize what $BIXT has........
Z
Just do a search for DDAmanda....will be the #1 Result.....all the info is on the site........
or Call/Text: 760 702-2009
Z
Apparently the market reaction is a big yawn.
Did he pay for them or did company award them ?
Working on any thing besides COVID ?
The historical pps chart says NO.
Does $BIXT have the cure for the Common Cold??
https://www.otcmarkets.com/stock/BIXT/news/Bioxytrans-Oral-Antiviral-Drug-to-Enter-Dose-Optimization-Clinical-Trial-for-COVID-19?id=431020
if you can or want to share where do I get this Amanda screener? and how do you use it
$BIXT: Is this news significant?
The cure for all viruses?...100% in Clinical Trials....... Wow.
https://www.otcmarkets.com/stock/BIXT/news/Bioxytrans-Oral-Antiviral-Drug-to-Enter-Dose-Optimization-Clinical-Trial-for-COVID-19?id=431020
With this discovery, we could use Nuclear Magnetic Resonance as a screening mechanism for viruses. In our COVID-19 case study we proved that the carbohydrate structures tested bound with high pico molar affinity, rarely seen with existing drugs, neutralize the viruses and that this data correlated with in vitro and the clinical trial results. We are at the dawn of a new age in virology that changes the current treatment paradigm of antivirals and vaccines to one of carbohydrate neutralization structures capable of efficiently neutralizing the virus to prevent cellular entry.”
About ProLectin-M
ProLectin-M is an oral galectin antagonist that prevents the entry of the SARS-CoV-2 virus into human cells. In recent clinical trials the drug achieved a 100% responders rate of negative PCR tests by day 7. In 3 days, the drug achieved an 88% responders rate of negative PCR tests. The treated population experienced no viral rebounds during the 14-day observation period. The company is preparing for a phase 3 clinical trial in order to seek regulatory approval.
Z
Science behind the product:
Bioxytran has a significant subject matter expertise in the formulation of an oral form of a Galectin inhibitor. The company was able to capitalize on Dr Platt’s many years of research and recent peer reviewed articles on Galectins and COVID-19 to quickly complete the proof of concept phase. Dr Platt, who has a PhD in carbohydrate chemistry, was the first scientist to express the gene, which he named Galectin, 28 years ago.
We know that the N-terminal domain (NTD) of the coronavirus spike protein is similar from genus to genus. On the COVID-19 spike protein scientists have elucidated a galectin fold on the side of the spike that should have a binding affinity to sugar carbohydrates like ProLectin. Animal studies on influenza (needs reference) have demonstrated that inhibiting galectin-1 improves outcomes in lethal influenza models. Other animal’s models show that galectin inhibitors act as immune modulators in cancer and other diseases.
Our molecule is designed to stay in the blood and attach to the COVID-19 protein spikes. When the inhibitor binds to the spike it effectively tags the virus for elimination through the liver. Galectins are theorized to participate in the antiviral defense which starts at the initial recognition of the virus before it binds to the entry receptor all the way through the activation and amplification of the innate and adaptive responses of the immune system.
Galectins are adhesion molecules and allow neutrophils to stay prepositioned in the pulmonary capillaries for a quicker reaction in case of infection. They are also involved in the trafficking of macrophages responsible for the inflammatory cycle of the cytokine storm. Additionally, research in cancer and viruses has demonstrated that galectins form a plaque on CD-8 T-cells which inhibit the adaptive immune response. Therefore, our galectin antagonist should not only reduce the viral load of COVID-19, but also modulate the immune response by reducing the trafficking of macrophages thereby reducing the cytokine storm and returning the immune system to homeostasis. We also expect it to restore functionality to the adaptive immune system by reactivating anergic T-cells that were covered in galectin plaque.
If given early in the disease, we believe that our first drug candidate, galectin antagonist, will block viral entry and tag the virus for elimination through the liver. In theory the virus will be eliminated from the blood stream after a couple of treatments. At a later stage in the disease pathology, a more potent IV solution, ProLectin- I could restore adaptive immune function to help eradicate the virus from the body. In severe COVID-19 patients the drug, ProLectin-A, could reduce the trafficking of macrophages responsible for the cytokine storm and restore immune homeostasis. ProLectin-F is designed to treat organ damage after virus is eliminated from the system.
Galectin Antagonist is the first-in-class of inhibitors to cover a range of Galectins associated with viral replication adhesion and immune system blockage (not modulation). The N-terminal domain (NTD) of the coronavirus spike protein is similar from genus to genus. On the COVID-19 spike protein the Galectin fold on the side of the spike has a binding affinity to sugar carbohydrates like Galectin Antagonist.
Galectins are members of a family of proteins called lectins. These proteins interact with carbohydrate sugars located on the surface, in between cells, and on the Galectin fold of the spike protein. These interactions cause the cells to change behavior, including cell movement, multiplication, and other cellular functions. The interactions between lectins and their target carbohydrate sugars occur via a carbohydrate recognition domain (CRD), within the lectins. Galectins have a CRD that binds specifically to sugar molecules. They have a broad range of functions, including regulation of cell survival and adhesion, promotion of cell-to-cell interactions, growth of blood vessels, regulation of the immune response and inflammation. During viral infections Galectins are upregulated and downregulated based on the type of virus.
Bioxytran intends to develop and, through third party contracts, manufacture oxygen therapeutics. Our oxygen therapeutics are a new class of pharmaceuticals that are administered intravenously to transport oxygen to the body’s tissues. Currently there are four drug candidates to treat a stroke. Abciximab from Eli Lilly is a platelet aggregation inhibitor. Clinical trials show little advantage over placebos and could lead to dangerous side effects, including more bleeding in patients. Cerovive from AstraZeneca is a Nitrone-based neuro protectant currently in phase III clinical trials which shows no significant benefit over placebos with respect to changes in neurological impairment as measured by the national institute of health stroke scale. Candesartan, from AstraZeneca, is an angiotensin receptor blocker which was used to control blood pressure. Its efficacy in stroke patients still must be proven. Ancod from Knoll Pharmaceuticals is an anti-coagulant that acts by breaking down the fibrinogen. It increases the risk of hemorrhage similar to those associated with tPA. Using our issued patents and proprietary technology, we intend to develop and manufacture BXT-25 and similar drugs for applications including treatment of stroke conditions. Our patent position consists of 2 parts: a patent related to our co-polymer technology issued in 2009 by the United States Patent and Trademark Office expiring in February 2029 (method patent for producing modified pectins consisting of neutral sugar sequences ) and assigned to us outright by David Platt; various methods to stabilize a single hemoglobin molecule that are in the public domain; Dr. Platt did not receive any compensation from the Company in consideration of his assignment of the patent. Additionally, Bioxytran, Inc. has an exclusive license for an FDA approved technology monitoring NADH (OxySense), the control marker in the body’s conversion of Oxygen to Energy, or the energy generating chain. The technology provides a clinical end-point for measuring oxygen supply to the brain in real-time. OxySense, developed by MDX LifeSciences, Inc., provide us with a rapid, cost-effective and validated development of safe new molecules that address unmet medical needs in disease indications resulting from hypoxia. MDX LifeSciences has licensed a patent (Tissue Metabolic Score for Patient Monitoring) to Bioxytran for clinical monitoring of oxygen delivery through oxygen carriers.
Volume | |
Day Range: | |
Bid Price | |
Ask Price | |
Last Trade Time: |