Alaunos Therapeutics Inc (TCRT)

[jondoeuk]

The PR is damage control, and nothing but an act of desperation. The company needs to execute and deliver

[jondoeuk]

Precigen UltraCarT https://www.prnewswire.com/news-releases/precigen-announces-clearance-of-ind-to-initiate-phase-11b-study-for-first-in-class-prgn-3006-ultracar-t-therapy-in-patients-with-relapsed-or-refractory-acute-myeloid-leukemia-aml-and-higher-risk-myelodysplastic-syndrome-mds-300770244.html

So the ZIOP POC trial still has an FDA hold placed on it, but Precigen's 2-day UltraCAR-T gets approval for a trial. Something doesn't add up here.

[jondoeuk]

Good luck with that......

The company has been under performing for years now. The TCR trial at the NCI is delayed yet again, the 3rd Gen CAR has an FDA hold still placed on it and Ad-RTS-hIL-12 is useless in rGBM like it was in melanoma and breast cancer. Meanwhile, the competition continues to move forward.

[ClayTrader]

* * $ZIOP Video Chart 11-21-18 * *

Link to Video - click here to watch the technical chart video

[ClayTrader]

* * $ZIOP Video Chart 11-13-18 * *

Link to Video - click here to watch the technical chart video

[barnovage]

Long.

[ClayTrader]

* * $ZIOP Video Chart 08-07-18 * *

Link to Video - click here to watch the technical chart video

[Plegee]

Something going on, second trading day in a row with a strong uptrend. Recent CC was enthusiastic, but sorely lacking in substance once again. Critical trial now delayed to 2nd half of 2018 it appears, a contradiction already from a 1st half prediction made just this past December. Hopefully some partnership negotiations are getting serious. Competition catching up, our keys to the Kingdom looking more like automatic glass doors at your neighborhood mall.

[Plegee]

Even if this stock triples here from an unlikely partnership announcement, this has been a horrible investment. Kirk's convoluted arrangement with XON is keeping suitors away, they just don't want to deal with his twisted sense of business reality. He has been a star in the past, certainly not in this case. CEO should have business acumen, not a research background. Another Ed Lamphier Another cash raise needed this year, maybe this time they use Big Ed's Pawn shop, can't be any worse than the last one.

[gator16]

SAME AS ALWAYS !!! GOOD NEWS STOCK DROPS>>BAD NEWS STOCK DROPS !!

[buckiii2]

Feb 12th slide. http://www.ziopharm.com/pipeline/presentations-publications

[ClayTrader]

* * $ZIOP Video Chart 02-06-18 * *

Link to Video - click here to watch the technical chart video

[Regis999]

Which Billionaire Randall Kirk Biotech company is the most capital efficient based upon market cap? $HALO by a mile.


ZIOPHARM Oncology, Inc. $ZIOP) Capital Raised since inception $ 619.232 million Market Cap $ 607.5 million

For every dollar ZIOP has raised in capital it has resulted in $.98 of Market Cap

Randall Kirk and affiliates owns 7.4% of ZIOP times $ 607.5 Million ZIOP market cap or $ 44.9 Million

Halozyme Therapeutics, Inc. (HALO) Capital Raised since inception $ 718.553 million Market Cap $ 2.63845 Billion

For every dollar HALO has raised in capital it has resulted in $3.66 of Market Cap

Randall Kirk and affiliates owns 18.5% of HALO times $ 2.638 Billion HALO market cap or $ 488 Million---10 TIMES the ownership of ZIOP !!

Intrexon Corporation (XON) Capital Raised since inception $ 1.370 Billion Market Cap $ 1.509 Billion

For every dollar XON has raised in capital it has resulted in $1.10 of Market Cap

Randall Kirk and affiliates owns 52.1% of XON times $ 1.370 Billion XON market cap or $ 713.8 Million

Which Kirk Biotech is likely to be acquired first: $HALO--

$HALO Tweets following science https://twitter.com/fezziwig2008

[dirtydozen911]

getting ready to pounce on this again......jumped out mid sept, with a nice gain......a little bit lower and POW!! GLTA

[sandyraveon]

ZIOPHARM reportrs clinical data from Data from T-Cell Therapy Programs; shows continued survival benefit
5:25 AM ET 12/11/17 | Briefing.com
Co announced data supporting its non-viral approach to rapid manufacture of chimeric antigen receptor (CAR)-modified T cells to treat patients with cancers Two trials demonstrated that first-generation SB-modified CD19-specific CAR+ T cells appear to provide long-term cancer control when infused after hematopoietic stem-cell transplantation (HSCT) for patients with advanced CD19+ malignancies and could be detected years after administration in some recipients. All seven patients with advanced CD19+ non-Hodgkin's lymphoma (NHL) that received autologous T cells were alive at a median survival of 40 months since infusion, with progression-free survival (PFS) reported at 86% and overall survival (OS) at 100%. For 19 patients with advanced CD19+ acute lymphoblastic leukemia (ALL) and NHL infused with allogeneic T cells following HSCT, nine patients were alive with a median survival of 31 months. The PFS rate and OS rates are 32% and 49%, respectively. Of the subset of eight patients who received donor-derived T cells after haploidentical HSCT, PFS and OS rates are 50% and 63%, respectively. Persistence of circulating SB-modified CAR+ T cells was demonstrated at two years in an autologous and allogeneic patient and for four years in two autologous patients.

[buckiii2]

https://www.investorvillage.com/smbd.asp?mb=16353&mn=92761&pt=msg&mid=17751869

[TREND1]

ZIOP= Profit/Loss = US$ -165.3M

[buckiii2]

https://www.bizjournals.com/boston/news/2017/11/20/ziopharm-says-its-brain-cancer-drug-helped-trial.html

[Plegee]

KITE helping all CRT, gene efiting stocks and cykotine switches (BLCM). Many articles suggesting this is the first acquisition of many in this group space area. Hopefully this continues to lift this stock until it is finally our turn. PFE is my wild guess as a suitor or partner. Have no idea what is taking Merck so long to advance their studies.

[dirtydozen911]

mr kirk has his hand in the cookie jar again.....what else is new!!!

[dirtydozen911]

this month long downtrend has sucked!...need her to go back to her roller-coaster mode....maybe today starts a new trend..gltu

[now invest]

Nice move thus far today... up 9% !! Maybe getting ready for a run??

[dirtydozen911]

might take a nibble on this tomorrow if overall market conditions are favorable......?..?..?

[ddbl_our_buck]

..thanks for that, Im leaning that way myself..
Check ONV* for a similar chart pattern and similar perspective on value.
cheers..

[dirtydozen911]

made lots of money on this the last few years.......usually stop trading this above 6.50.......was getting ready to jump in again, but an insider sell and some other developments, have changed my mind........I think she`s gonna take a dive......if she gets down in the 4`s , might give her another look, and geta big chunk to sit on .....???????????

[Plegee]

Yes, underwhelmed. CVI has the reputation of aggressively working their stakes in various invested companies; apparently DNDN and CRMD have been in their stable in the past. Disappointed this is the best we could do for the ridiculous discount we offered. Things just don't feel right. Empty/over promises by Kirk and Cooper. Plan to be out if nothing material happens before the 90 day CVI lockout expiration. This thing will be optioned pinned to death.

[wiltonio]

CVI Investments, Inc. has filed a new 13G, reporting 6.8% ownership in $ZIOP - https://fintel.io/so/us/ziop

[Plegee]

Down 37 cents or 5% on no news today so the MM can play his little games and have all those 7 call options expire worthless. Blatant manipulation. Closed at $6.99 . . . . what a coincidence with those 2700+ 7 strike options open.

[Pennybuster]

ZIOPHARM Oncology, Inc. Nasdaq: $ZIOP 11-10-16 announced that Laurence Cooper, M.D., Ph.D., Chief Executive Officer, will present at the Jefferies 2016 London Healthcare Conference on Thursday, November 17, 2016 at 4:40 p.m. GMT.
As previously announced, ZIOPHARM will host a conference call and webcast slide presentation Thursday, November 17, 2016, at 8:00 am ET to discuss information featured at the Society for Neuro-Oncology (SNO) Annual Meeting, including updated data from the Company’s Phase 1 study of Ad-RTS-hIL-12 + veledimex in high-grade glioma. The call can be accessed by dialing [phone] (U.S. and Canada) or [phone] (international). The passcode for the conference call is 11110235. To access the slides and live audio webcast, or the subsequent archived recording, visit the "Investors & Media" section of the ZIOPHARM website at www.ziopharm.com. A replay of the call will be available on the Company's website for two (2) weeks.

About ZIOPHARM Oncology, Inc.:

ZIOPHARM Oncology is a Boston, Massachusetts-based biotechnology company employing novel gene expression, control and cell technologies to deliver safe, effective and scalable cell- and viral-based therapies for the treatment of cancer and graft-versus-host-disease. The Company's immuno-oncology programs, in collaboration with Intrexon Corporation (NYSE:XON) and the MD Anderson Cancer Center, include chimeric antigen receptor T cell (CAR-T) and other adoptive cell-based approaches that use non-viral gene transfer methods for broad scalability. The Company is advancing programs in multiple stages of development together with Intrexon Corporation's RheoSwitch Therapeutic System® technology, a switch to turn on and off, and precisely modulate, gene expression in order to improve therapeutic index. The Company's pipeline includes a number of cell-based therapeutics in both clinical and preclinical testing which are focused on hematologic and solid tumor malignancies.


Contact:
Lori Ann Occhiogrosso
ZIOPHARM Oncology, Inc.
617-259-1987
[e-mail]

David Pitts
Argot Partners
212-600-1902
[e-mail]

[DrStockonomics]

ZIOP remains a buyout candidate. Lowering debt to make it more attractive to potential buyers. As for XON, it remains, in my opinion, a solid long term investment. Very volatile right now, but eventually will be a $100 stock in the not to distant future. They just have to many sectors they are involved in to fail.

[foster g]

Anyone know why the big rise today? XON good investment?

[Fibanotch]

let it pull back 30% ...then u'll get a good bang for ur buck!

[jondoeuk]

The webcast for the second quarter financial results will start at 4:30 PM ET on the 9th of this month http://ir.ziopharm.com/eventdetail.cfm?EventID=174958

[growacet]

Juno being sued, is Ziopharm next?

ZIOP JUNO and KITE mentioned:

http://www.avoidthebag.com/2016/07/juno-therapeutics-being-sued-is.html

[tpizzazz24]

Blood sucking ambulance chasers if you don't know that by now. Slumdog

[blackcat]

Those CA suits mean nothing. The law firms are pure ambulance chasers. It will likely be dismissed and companies carry insurance against them any way.

[stanace27]

Chart is wonderful

[louisgeorge]

With a lawsuit on the way, no way this will go up. Down it will go.

[stanace27]

Shorts covering will move this back to over $5

[growacet]

Shorts have made huge $$$ on ZIOP

Longs? Anyone who bought in after ZIOP paid Anderson $57.5 million in shares for the partnership deal....not so good. Although those who bought in back in October of 2014 around $2 or $3, they'd still be up...although they're probably kicking themselves if they didn't take any profits at $10+

XON shareholders who got free divy shares, they're obviously green at any price, although they too are probably kicking themselves if they didn't dump and take the money.

Who's buying right now? My guess is its probably short players covering to crystalize some awesome gains. And with all the uncertainty right now over the trial and the need for further financing on top of the ambulance chasers investigating....Overall a good time to cover off imo, when demand should be very low.

Who knows...they may just reload and short more going forward, maybe even try and pump it back up.

[stanace27]

What you talking about this will pass $5 tomorrow

[louisgeorge]

Just dump this, told u guys to do this days ago.

[stanace27]

New 52 week low just registered

[blackcat]

It's part of a sector wide sell down today.

[dave7933]

So it was up early this morning 8% on the news. Now it's down almost 8% why is that?

[jondoeuk]

ZIOPHARM Provides Update Regarding Phase I Study of Gene Therapy Candidate Ad-RTS-hIL-12 in Brain Cancer

BOSTON, July 19, 2016 (GLOBE NEWSWIRE) -- ZIOPHARM Oncology, Inc. (Nasdaq:ZIOP) today provided an update regarding the Company's ongoing multicenter Phase I study of Ad-RTS-hIL-12 + orally administered veledimex in recurrent or progressive glioblastoma (GBM) or grade III malignant glioma.

The patient death resulting from intracranial hemorrhage in the third cohort of this Phase I study was deemed unrelated to study drug following the receipt and analysis of additional information by the sponsor and the study's Safety Review Committee. As with all study events, the Company expects to report the data to the U.S. Food and Drug Administration in accordance with the study's protocol and applicable regulations. As previously announced, the study remains open for enrollment. The Company expects to provide further updates on the progress of the study, including longer-term survival follow up, at an appropriate meeting later this year.

"Recurrent GBM is a devastating disease with an expected overall survival that remains far too short as this case illustrates," said Francois Lebel, M.D., Executive Vice President, Research and Development, Chief Medical Officer at ZIOPHARM. "Preliminary overall survival in this study, including a median follow-up of over 8 months in the first dose cohort, remain encouraging, and we will continue to work diligently toward understanding the full potential of Ad-RTS-hIL-12 + veledimex in this disease, with the goal of providing safe and effective treatment options to these patients."

http://ir.ziopharm.com/releasedetail.cfm?ReleaseID=980076

[growacet]

Sure....here it is

You didn't include all of the definitions, here it is from the same Merriam-Webster site. Words can have more than 1 or 2 meanings, I shouldn't have assumed you'd know that. Of course you conveniently left out the definition that applied...But with ZIOP longs I'm used to seeing selective reasoning being used, longs only see what they want to see instead of taking in the full picture, its why so many paid $8+

: not likely to be true or correct : giving reason to doubt or question something
: likely to be bad : not worthy of trust
: not certain : unknown or undecided

http://www.merriam-webster.com/dictionary/questionable

Try to slow down, it'll save you from making mistakes.

Same thing happened when UTIMCO chose to dump the ZIOP shares they had discretionary authority over.....Some morons thought they had no choice, that it was mandated they had to sell. If they'd only read ALL the info instead of just what they wanted to see.

[blackcat]

I referred to their therapy as "questionable"....which means exactly what you said...their drug, "either will or will not work". That's what questionable means..

No-that is not what it means.


Simple Definition of questionable

: not likely to be true or correct : giving reason to doubt or question something

: likely to be bad : not worthy of trust
Source: Merriam-Webster's Learner's Dictionary

So-when you stated that their therapy is questionable, I assumed you feel that it was not likely to work.

I'm done with this. You're welcome to the last word if you want it.

[growacet]

Do you understand English?

I referred to their therapy as "questionable"....which means exactly what you said...their drug, "either will or will not work". That's what questionable means...if I thought their therapy wouldn't work I would have expressed that view...like you I don't know.

And it won't be proven one way or another in a phase I trial, even if they ever get to the 48 patients cited at clinicaltrials.gov.

How long did they know of this death before notifying shareholders? According to news being released it already quashed a $50,000,000 share offering the day before the news hit....Why wasn't the news released Thursday?

[blackcat]

Do you have any idea how trials actually work? I do.
I have worked for a Biotech, helped with trial design, recruited patients, and followed them through the trial and beyond.

ZIOP's drug either will or will not work. We will learn in time. You seem to have decided it will not. That's fine, but posting FUD is not.