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Aevi Genomic Medicine, Inc. (GNMX)

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Last Post: 3/19/2019 8:28:08 AM - Followers: 16 - Board type: Free - Posts Today: 0

https://aevigenomicmedicine.gcs-web.com/static-files/550762a8-6d9f-4cd6-933f-5ff7e8e12ab8



Avei Genomic Medicine, Inc., a clinical stage biopharmaceutical company, researches and develops novel therapies for pediatric onset and life-altering diseases in the United States. The company's lead product candidates include AEVI-001, a glutamatergic neuromodulator, which has completed Phase II/III SAGA trial for the treatment of a genetically-defined subset of adolescent attention deficit hyperactivity disorder patients who have genetic mutations that disrupt the mGluR network resulting in glutamate imbalance; and AEVI-002, an anti-LIGHT monoclonal antibody that is in Phase Ib clinical trial for use in severe pediatric onset Crohn's disease. The company also develops AEVI-005, which is in preclinical stage for the treatment of pediatric rare diseases. It has a strategic collaboration with Kyowa Hakko Kirin Co., Ltd. for an early stage monoclonal antibody program in an ultra-orphan pediatric indication. The company was formerly known as Medgenics, Inc. and changed its name to Aevi Genomic Medicine, Inc. in December 2016. Aevi Genomic Medicine, Inc. was founded in 2,000 and is based in Wayne, Pennsylvania.

Related Publications

Hakonarson H, Kao C, Squires LA, et al. 6.61 PREDICTIVE VALUE OF GLUTAMATERGIC NETWORK GENE MUTATION TESTING FOR ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CHILDREN AND ADOLESCENTS IN AN OUTPATIENT PSYCHIATRY SETTING. Journal of the American Academy of Child & Adolescent Psychiatry. 2016;55, S224.
http://www.jaacap.com/article/S0890-8567(16)31609-4/abstract

Elia J, Khan M, Kim C, et al. 6.67 GLUTAMATERGIC NETWORK GENE MUTATIONS IN ADOLESCENTS AND CHILDREN WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER. Journal of the American Academy of Child & Adolescent Psychiatry. 2016;55, S226.
http://www.jaacap.com/article/S0890-8567(16)31615-X/abstract

Elia J, Glessner JT, Wang K, et al. Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nature genetics. 2012;44(1):78-84.
https://www.ncbi.nlm.nih.gov/pubmed/22138692

Byrnes KR, Loane DJ, Faden AI. Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders. Neurotherapeutics. 2009;6(1):94-107.
https://www.ncbi.nlm.nih.gov/pubmed/19110202

Harvey BH, Shahid M. Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical translational models. Pharmacol Biochem Behav. 2012;100(4):775-800.
https://www.ncbi.nlm.nih.gov/pubmed/21708184

Pitsikas N. The metabotropic glutamate receptors: potential drug targets for the treatment of anxiety disorders? Eur J Pharmacol. 2014;723:181-4.
https://www.ncbi.nlm.nih.gov/pubmed/24361306

Yasuhara A, Chaki S. Metabotropic glutamate receptors: potential drug targets for psychiatric disorders. Open Med Chem J. 2010;4:20-36.
https://www.ncbi.nlm.nih.gov/pubmed/21160908

McDonald-McGinn DM, Sullivan KE, Marino B, et al. 22q11.2 deletion syndrome. Nat Rev Dis Primers. 2015;1:15071.
https://www.ncbi.nlm.nih.gov/pubmed/27189754

Cardinale CJ, Wei Z, Panossian S, et al. Targeted resequencing identifies defective variants of decoy receptor 3 in pediatric-onset inflammatory bowel disease. Genes Immun. 2013;14(7):447-52.
https://www.ncbi.nlm.nih.gov/pubmed/23965943

Kugathasan S, Baldassano RN, Bradfield JP, et al. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat Genet. 2008;40(10):1211-5.
https://www.ncbi.nlm.nih.gov/pubmed/18758464

Steinberg MW, Shui JW, Ware CF, et al. Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners. Semin Immunopathol. 2009;31(2):207-21.
https://www.ncbi.nlm.nih.gov/pubmed/19495760

Wang J, Anders RA, Wang Y, et al. The critical role of LIGHT in promoting intestinal inflammation and Crohn's disease. J Immunol. 2005;174(12):8173-82.
https://www.ncbi.nlm.nih.gov/pubmed/15944326

Lin WW, Hsieh SL. Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer. Biochem Pharmacol. 2011;81(7):838-47.
https://www.ncbi.nlm.nih.gov/pubmed/21295012

 

FINRA REG SHO February 1st 2019 Short Volume - 1,092,671
GNMX
Current Price
Volume:
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GNMX News: Amended Statement of Ownership (sc 13g/a) 02/13/2019 04:33:46 PM
GNMX News: Current Report Filing (8-k) 02/12/2019 04:47:45 PM
GNMX News: Factors of Influence in 2019, Key Indicators and Opportunity within Park Hotels & Resorts, Planet Fitness, Aevi Genomic Medic... 02/12/2019 08:25:00 AM
GNMX News: Current Report Filing (8-k) 01/02/2019 04:34:15 PM
GNMX News: Aevi Genomic Medicine Announces Top-Line Results from Placebo-Controlled ASCEND Trial (Parts A & B) of AEVI-001 in Children w... 01/02/2019 04:30:00 PM
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#173   Break .26 during regular hours could run to AugustaFriends 03/19/19 08:28:08 AM
#171   :) 420man 03/12/19 12:36:00 PM
#170   Sure wish I had enough funds to force 420man 03/08/19 06:41:31 PM
#169   Looks like a potential squeeze starting here!!! 420man 02/14/19 03:42:27 PM
#168   Getting some traction, but worried about financials coming up... 420man 02/14/19 03:20:21 PM
#167   sc 13g/a Baker Bros 5.5%, warrants exercise @ Wildbilly 02/14/19 10:16:06 AM
#166   Tick tock :) 420man 02/06/19 07:56:37 PM
#165   Interesting play on watch. Betting big on low INTL 02/03/19 11:12:16 AM
#164   ;-) Rocketstockpix 02/02/19 07:15:37 PM
#163   Love what I see here, def think we Copacetic112 02/02/19 03:37:15 PM
#162   Looking for gap to be filled..... Tic tock 420man 02/02/19 12:44:34 PM
#161   * * $GNMX Video Chart 02-01-2019 * * ClayTrader 02/01/19 05:41:27 PM
#160   Squeeze coming here SOON! 420man 02/01/19 05:13:58 PM
#159   Vas ist los? Wildbilly 02/01/19 10:35:52 AM
#158   .60 420man 01/17/19 05:08:10 PM
#157   Oh no the angel of death clay. jbags187 01/16/19 01:04:12 AM
#156   A little defense please. Wildbilly 01/08/19 07:05:29 AM
#155   * * $GNMX Video Chart 01-07-19 * * ClayTrader 01/07/19 05:41:56 PM
#154   Recent bio tankers SGYP & HSGX took 5-6 Wildbilly 01/07/19 10:03:15 AM
#153   Day 3 bounce? Wildbilly 01/07/19 08:42:05 AM
#151   They will have to put a R/S up RLBTrader 01/05/19 10:38:41 AM
#150   Ugh lol maz1978 01/04/19 08:31:14 PM
#149   It is 1:9000 RS, someone just post it handMMJ 01/04/19 08:07:22 PM
#148   I'm sorry man...when answering I was referring to maz1978 01/04/19 07:14:00 PM
#147   This is Forward. Bro , means no RS, handMMJ 01/04/19 06:26:38 PM
#146   Do you consider fundamentals in conjunction to your 420man 01/04/19 04:29:47 PM
#145   Sorry wrong board. My bad. Pnypnchr 01/04/19 04:25:07 PM
#144   An RS here would only be useful for 420man 01/04/19 04:17:26 PM
#143   * * $GNMX Video Chart 01-04-2019 * * ClayTrader 01/04/19 04:13:40 PM
#142   Absolutely, an RS could be the best thing Pnypnchr 01/04/19 03:18:37 PM
#141   Yep...an rs doesn't bother me in the least maz1978 01/04/19 11:42:19 AM
#140   R/S Y or N, Max, MD is zipped handMMJ 01/04/19 11:27:33 AM
#139   I hope so I’ll be buying !!!! omri 01/03/19 08:19:38 PM
#138   Me too!!! Glta omri 01/03/19 08:18:41 PM
#137   You may actually be on target with your 420man 01/03/19 07:52:40 PM
#136   This will bounce, just a matter of time. 420man 01/03/19 06:11:38 PM
#135   Starter taken...extremely oversold maz1978 01/03/19 04:17:21 PM
#134   Totally oversold. Strong buy here and huge bottom aristotelisonassis 01/03/19 03:54:03 PM
#133   Going to drop another 35% over next 3 willlbone 01/03/19 12:56:41 PM
#132   That's a huge gap down that will likely 420man 01/03/19 12:44:27 PM
#131   Possible, but with RSI @ .18 it's currently 420man 01/03/19 12:25:52 PM
#130   Retail should wait until sub teens. willlbone 01/03/19 12:03:23 PM
#129   When the seller(s) realize that retail is willing 420man 01/03/19 09:44:44 AM
#128   It´s me... ;) Klinsmann 07/23/18 03:38:17 PM
#127   hello DD 07/23/18 03:23:16 PM
#126   2,30 - 2,60 hod - still nobody here Klinsmann 02/07/18 04:49:25 PM
#125   Over 2$ and still strong! Questions?!? lol Klinsmann 02/01/18 04:56:21 PM
#124   Still in love... :) Klinsmann 01/31/18 03:27:04 PM
#123   Keeping green step by step up, very nice Klinsmann 01/25/18 04:22:50 AM
#122   12 month consensus target price of $5.17 PennyWorld 01/24/18 06:21:29 PM
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