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Medical - Drugs
Acusphere, Inc. (ACUS)
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10/10/2018 12:04:54 PM
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Today : Friday 20 January 2012
Acusphere, Inc. (ACUS.PK) today announced that its stockholders voted to approve the proposed 1-for-10 reverse stock split of the Company's common stock at its Special Meeting of Stockholders held today.
See post 749 for press release, also currently a sticky post.
End Update 01.20.2012
Proxy Notice Of Special Meeting Received via US Mail. Posted a sticky on some highlights, I can't find a link to it on the ACUS website but one can likely find it searching the SEC, maybe?
They are asking for a 1-10 reverse stock split. The proxy has lots of interesting stuff in it. Maybe someone can find a link to it and post it.......
End Update 12.23.2011
Another Letter to the Shareholders was issued yesterday and can be read as the first sticky post.
A line from the letter is:
"We have now arrived at an important juncture, and we need your support to help effect a reverse stock split to allow the Company to finance the completion of our strategic direction."
So a reverse split may be coming. I have lightened up on my own shares but as of now still hold some and may buy or sell more as the future unfolds.
End 12.20.2011 update.
Imagify was shot down by the FDA advisory panel a couple years ago ,give or take a little, I think it was 16-1, mainly because Imagify had not been tested against a placebo. They had run trials against the "Standard Of Care," Nuke testing.
On June 8th 2011 ACUS announced that Imagify has been granted a SPA by the FDA for an addtional phase III against a placebo.
Also on June 8th 2011 ACUS announced that they hoped to complete their work to the EU for an MMA application for Imagify in the 2nd half of 2011.
You can read about these latest developments here, and I will try to figure out how to make this post a sticky.
Since I-Hub did away with their spell checker I no longer run my posts through one, so I apoligize to those who may be offened by this fact, in advance.
End of 10.07.2011 update.
Imagify is a cardiovascular drug for the detection of coronary artery disease, the leading cause of death in the United States & Europe.
: On October 24, 2008, Acusphere, Inc. (the "Company") announced the signing of a definitive agreement with Cephalon, Inc. ("Cephalon") to provide $20 million in upfront financing by purchasing a $15 million senior secured convertible note and by paying a $5 million upfront fee for an exclusive worldwide license to AI-525, a preclinical-stage injectable formulation of celecoxib using Acusphere's proprietary Hydrophobic Drug Delivery System (HDDS?) technology. On July 7, 2004, Acusphere announced a $70 million partnership for European development and marketing rights to Nycomed. From this partnership, Acusphere has currently received $12 million in milestone payments. An additional $58 million in milestone payments are related to regulatory approvals and achievement of certain sales goals.
Market Potential & Competition
: The potential market in the US for Imagify is estimated to be roughly $2 billion annually. It is estimated that more than 10 million procedures are done each year in the U.S. to detect coronary artery disease. The leading procedure to detect coronary heart disease is nuclear stress testing, which costs roughly double the amount to implement, takes significantly more time to administer, and is arguably more harmful to the patient/environment.
: The FDA granted ACUS an Advisory Panel Meeting for Imagify on December 10th, 2008. The panel voted against recommendation by a vote of 16-1. The PDUFA date is set for February 28, 2009. On this date the FDA will decide whether or not they approve of the drug. The company is also working with Nycomed to submit its MAA filing in Europe.
: AI-850 is a Phase 1 clinical trial completed product candidate that utilizes hydrophobic drug delivery system to improve the dissolution rate of a cancer drug.
On March 31, Acusphere licensed the property rights to its Hydrophobic Drug Delivery System™ (HDDS) for oncology applications to Cephalon for $10 million. Per the last conference call, the company may choose to license out the HDDS system to other companies for other applications. (Oncology is only one of the potential applications.)
If you would like to listen to Acusphere's most current conference calls or presentations, please go to the following:
Current share count:
Authorized Common Stock: 250 million shares
Outstanding Common Stock: 49.51 million shares
Preferred Stock convertible to common: 25.2 million shares
Acusphere, Inc., a specialty pharmaceutical company, develops new drugs and formulations of existing drugs using its proprietary porous microparticle technology in the United States. Its porous microparticle technology enables to control the size and porosity of particles, including nanoparticles and microparticles. The company develops products in the areas of cardiology, oncology, and asthma. Its lead product candidate Imagify, a cardiovascular drug, is in Phase 3 clinical development for the detection of coronary artery disease. The company?s products also include AI-850, a Phase 1 clinical trial completed product candidate that utilizes hydrophobic drug delivery system to improve the dissolution rate of a cancer drug; AI-128, a Phase 1 clinical study completed formulation of asthma drug. Acusphere was founded in 1993 and is headquartered in Watertown, Massachusetts.
ACUS Detailed Quote
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I seen somewhere after 10 years they can
10/10/18 12:04:54 PM
09/07/18 10:13:48 AM
zon$x 2 shares in my opinion someone is
09/07/18 10:12:05 AM
I've never figured it out either. I see
09/06/18 09:32:37 PM
What do you think the one share sale
09/06/18 09:28:07 PM
When those 0001's take off one can make
08/22/18 01:32:35 PM
I actually bought txh@e instead of txh#d Like
08/21/18 09:07:17 PM
I'll have to look at it. Not too
08/13/18 09:25:15 AM
Can you tell what happened with TXH#d I
08/11/18 11:10:19 PM
The only true way to find out is
08/10/18 11:43:26 AM
Could be a while got to get interest
08/09/18 10:03:46 PM
This thing moves on air!
05/23/18 09:27:54 PM
05/14/18 01:50:31 PM
Low float money taker you buy it up
05/14/18 10:55:31 AM
Lets move tomorrow!
05/13/18 10:25:17 PM
Agree. Every day it is insanely thin to
05/11/18 10:05:24 PM
This could easy go to the sky ..just
05/11/18 05:26:51 PM
And a seller into the 045 bid.
05/10/18 02:35:34 PM
Not sure. Good money can be made if
05/10/18 11:49:14 AM
Wonder what needs to be done so people
05/09/18 08:35:08 PM
So far if you click on the 1
05/09/18 08:26:20 PM
05/09/18 01:17:23 PM
What Idiot sold to the 068 bid?? Unbelievable!
05/08/18 04:02:54 PM
No selling into the 068 bid. Good sign
05/08/18 03:09:11 PM
Don't sell into the .068 bid guys and
05/08/18 12:51:00 PM
21k to .25 now. 3 mm's bidding .05+
05/07/18 01:36:56 PM
05/07/18 10:06:17 AM
Agree. Any small buying volume and we go!
05/07/18 08:42:21 AM
ACUS $$$$ COULD HAVE A MASSIVE WEEK..SO THIN
05/07/18 12:35:30 AM
L2: 20k 068
05/04/18 03:12:16 PM
057 46k shares to .25 380%
05/04/18 02:32:20 PM
Who has the 25k shares for sale in
05/04/18 01:37:56 PM
ACUS..... Yes look at CLWT and IMTE. If
05/04/18 10:46:59 AM
05/04/18 10:41:29 AM
Low floats move so fast I bought 1000
05/03/18 11:01:42 PM
Looks worse than it is as a 4k
05/03/18 09:14:07 PM
On the flip side, tomorrow we'll show a
05/03/18 04:03:31 PM
Good to see the bid crept up to
05/03/18 03:28:54 PM
$6 sell drops us 56%. Funny
05/03/18 01:48:12 PM
2000 buy there on the ask .133
05/03/18 11:54:16 AM
Just 37k now to .25
05/03/18 10:32:16 AM
47k to .25 on L2
05/03/18 10:16:30 AM
Dam!! f we had 2 million volume like
05/02/18 10:54:04 PM
This Could Easily go up like IMTE DID
05/02/18 10:43:03 PM
Not a bad day at all. bid increased
05/02/18 08:51:18 PM
Super thin to $1 recent 5 days, 400%
05/02/18 03:53:18 PM
Bid uptick .055. 90k on ask is gone
05/02/18 03:50:25 PM
05/02/18 03:49:38 PM
Need some buying volume but no selling into
05/02/18 02:50:26 PM
05/02/18 12:12:36 PM
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