AIkido Pharma Inc (AIKI)

[Taurus69]

$aiki $1.11 v -0.04 (-3.48%)
Volume: 3,887,795 @07/31/20 7:59:52 PM EDT

[Viewmont]

A good PR and news on AIKI should be delivered next week! IMO.
It's been a while we hear directly from AIKI.

[Viewmont]

NEWS! Hoth Therapeutics Executes Licensing Agreement of VNLG-152 for Treatment of Dermatological Diseases
Hoth to receive equity stake in Isoprene, full license of VNLG-152 and royalties from Isoprene for all other fields including Oncology
NEW YORK, July 31, 2020 /PRNewswire/ -- Hoth Therapeutics, Inc. (NASDAQ: HOTH), a biopharmaceutical company, today announced it has executed a licensing agreement with Isoprene Pharmaceuticals, Inc. to acquire the rights to VNLG-152, a novel retinamides (Retinoic acid metabolism blocking agents, or RAMBAs) for the treatment of dermatological diseases. Isoprene is a cancer therapeutic company that is a University of Maryland, Baltimore New Venture Initiative start-up.


This agreement, which formalizes the previously announced Letter of Intent between the two companies, will also grant Hoth royalty payments from Isoprene for any use of its VNLG-152 including Oncology.

Researchers at the University of Maryland Baltimore discovered novel retinamide RAMBAs and validated their therapeutic utility in animal models of breast and prostate cancer. RAMBAs inhibit the cellular enzyme that metabolizes all-trans retinoic acid (ATRA), which actively directs cells to mature in a controlled manner to ensure normal growth.

In addition to enhancing the beneficial effects of ATRA, the mechanism of action for these RAMBAs has been shown to involve degradation of Mnk 1/2 and suppression of the oncogenic eIF4E pathway. For potential use in treating dermatological conditions, UMB researchers obtained promising early results demonstrating that lead retinamide RAMBAs have equal or superior effects over approved retinoids (ATRA and 13-CRA) to inhibit proliferation of normal human adult keratinocytes and sebocytes, and antikeratinizing effects in reconstructed human epidermis. Initial toxicity profiles for a panel of RAMBAs [Njar et al., 2006] also showed good indications for safe therapeutic use.

These novel RAMBAs block the normal metabolism of endogenous ATRA in cells, increasing the beneficial effects of ATRA. They provide a unique approach to achieve the therapeutic benefit of retinoid therapy while potentially circumventing the adverse events associated with it, a very important property for application to dermatology therapy. ATRA deficiencies are associated with dermatological diseases (acne and psoriasis), and retinoid derivatives have been one of the mainstay therapies for acne. Liarozole is in clinical use for the treatment of psoriasis and ichthyosis. Dermatological retinoid deficiencies are characterized by hyperkeratinization and desquamation and include diseases such as acne, eczema, psoriasis, cold sores, wounds, burns, sunburn, ichthyosis, skin cancer, and Kaposi's Sarcoma, all of which are plausible targets for retinamide RAMBA therapy.

Mr. Robb Knie, Chief Executive Officer of Hoth, commented, "Hoth is pleased to finalize this licensing agreement of a novel therapy that has shown such promise in targeting such a wide array of dermatological afflictions. This latest license agreement reinforces Hoth's commitment to developing novel therapies for multiple skin diseases."

About Hoth Therapeutics, Inc.
Hoth Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing new generation therapies for dermatological disorders. Hoth's pipeline has the potential to improve the quality of life for patients suffering from indications including atopic dermatitis, chronic wounds, psoriasis, asthma and acne. Hoth has also recently entered into two different agreements to further the development of two different vaccine prospects to prevent or treat COVID-19. To learn more, please visit www.hoththerapeutics.com.

[georgie18]

AIKI...$1.28...in the P/M...

[$oldier Hard]

Got a starter in $AIKI today.

[Viewmont]

Hopefully an up day tomorrow?

[Viewmont]

We should be hearing a follow up update from the following news/pr! IMO. https://www.otcmarkets.com/stock/AIKI/news/story?e&id=1641643

[Viewmont]

https://www.tradingview.com/symbols/NASDAQ-AIKI/technicals/

[Viewmont]

https://www.barchart.com/stocks/quotes/AIKI/opinion

[Viewmont]

Yup!

[mining101]

We will see...

[Icanslim]

Thanks starkd.

[starkd748]

Its means dilution for a quick cash infusion

[Icanslim]

Great point

[Icanslim]

Offerings not always bad, correct? Or too risky to hold through one?

[starkd748]

The chart its below the 50 ma....Which means it cant hold gains...An offering must be coming

[Icanslim]

what do you not like about this penny? Thanks in advance.

[tickersym]

Great Loading time on the DIP!

GLTA

[TrendTrade2016]

should have listened...
TrendTrade2016 Monday, 07/20/20 05:15:21 AM
Re: None 0
Post #
7916
of 7995
AIKI IS GARBAGE STAY AWAY!!

[starkd748]

Longterm is its barely above the 50ma

[mick]

$AIKI Alkido Pharma Inc (AIKI)
1.21 ? -0.01 (-0.82%)
Volume: 7,076,592 @07/24/20 7:59:16 PM EDT
Bid Ask Day's Range
1.18 1.2 1.13 - 1.32
AIKI Detailed Quote

[Viewmont]

http://schrts.co/SNZySEMg
Added some today, didn't get the low tho.

[mining101]

Look at the close and don’t post weired charting. Better check longterm trend

[starkd748]

More downtrend on the intraday look at the trend

[mining101]

How many more?

[tickersym]

Nice Dip! Added more!

[Viewmont]

$1.24 seems cheap today. This is preparing for a huge move up it looks like!

[Viewmont]

I agree!

[mining101]

Up again

[tickersym]

This things seems ready to Explode!!!

GLTA

[starkd748]

And whut do we have here

[getyourownshares]

Love the dip n rip

[Viewmont]

Nice huh!

[420man]

Offering on tap......
Clearly pushing SP up prior to announcing Tute offering. Same shizz different day. Be careful!

[BluSkies]

WOW!!

[Viewmont]

AIKI up she goes $1.32 after hours.

[mining101]

Strong closing

[georgie18]

AIKI...$1.23...Hit $1.28 Hod off the $1.12 bounce...

georgie18 Tuesday, 07/21/20 09:53:06 AM
Re: None 0
Post #
7962
of 7976
AIKI...$1.12...Dip filled the open gap this morning...should move hard from here...imo...we shall see...

[weedtrader420]

Off to the Races

[mining101]

Push the button

[BluSkies]

PUSH!

[mining101]

Waiting for more on Aikin- let’s go

[mining101]

Any news

[mining101]

It’s Rolling

[Viewmont]

Up 12% to $1.20 so far. Hopefully it continues going up!

[Viewmont]

Buy Technicals is back! https://www.tradingview.com/symbols/NASDAQ-AIKI/technicals/

[mining101]

If someone paid 3 dollar, why not paying 1 dollar for that stock?!?

[BluSkies]

Is this still a hold?

[posilock]

Wait for it lol..

[Viewmont]

AIKI consolidation time it looks like before the big take off?