Replies to post #32126 on Ariad Pharmaceuticals Inc fka ARIA

[jaybe]

Here's another promising excerpt from Parkinson's patent...

We have also found that the concentration of ponatinib in the brain tissue of the subjects receiving 30 mg of ponatinib can significantly exceed the concentration needed to increase the protective function of the gene product, parkin, in brain cells, in subjects having PD.

These results indicate that in these experiments, exposure to ponatinib was 2.79 times greater in brain relative to blood on an area under the curve (AUC) basis and 2.26 times greater on a the basis of maximum concentration observed (Cmax). The observed elimination half-life was also longer in brain than in blood.