Avid Bioservices Inc (CDMO)

[biopharm]

Why not use Bavituximab?

Anthony Fauci knows about Bavituximab=Cape Town SA

djohn-- I think you may be right and Bavituximab will be used. First, Peregrine will capitalize on a partnership to use the Bavi collaboration trials with oncology, where there is a patent cliff fistful of dollars ready be to tossed off this cliff, where the PS targeting platform will soon be .. hopefully going global.

Dr. Anthony Fauci

The NIAID budget for fiscal year 2013 was approximately $4.5 billion. Dr. Fauci serves as one of the key advisors to the White House and Department of Health and Human Services

Dr. Fauci also is the long-time chief of the NIAID Laboratory of Immunoregulation. He has made many contributions to basic and clinical research on the pathogenesis and treatment of immune-mediated and infectious diseases. He helped pioneer the field of human immunoregulation by making important basic scientific observations that underpin the current understanding of the regulation of the human immune response. In addition, Dr. Fauci is widely recognized for delineating the precise mechanisms whereby immunosuppressive agents modulate the human immune response.

http://www.niaid.nih.gov/ABOUT/DIRECTORS/BIOGRAPHY/Pages/biography.aspx

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Who used to work in Dr. Fauci's lab?: Dr. Douglas M. Powell

Dr. Powell received his Ph.D. in Genetics from George Washington University for work on HIV in the lab of Dr. Anthony Fauci, who is Director of The Laboratory of Immunoregulation and the National Institute of Allergy and Infectious Diseases.

http://www.zoominfo.com/s/#!search/profile/person?personId=443667709&targetid=profile

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Dr. Powell is speaking at the World Vaccine Congress in Washington, D.C. this week. Here's a summary of what he has been working on lately. Dr Douglas Powell, Director of Immunology, Antigen Express As an H5N1 virologist and immunologist, Antigen Express Director of Immunobiology Doug Powell studies the immune response H5N1 influenza vaccines and infection.

http://www.pharmamanufacturing.com/blogs/onpharma/avian-flu-not-if-but-when-immunologist-dr--douglas-powell-on-new-vaccine-development/

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Look who is on the "scientific board" at Antigen Express based in Worcester, MA ( for those who don't know... "Woostah" is 50 miles west of Boston ) so you tell me if its more likely that an employee at Antigen Express ventures further west to Tustin, CA for the warmer weather or for the PS targeting platform that will go global. Look for the words "Bavituximab - Global Development"

http://investorshub.advfn.com/boards/read_msg.aspx?message_id=93804265&txt2find=nikoletta

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Dr. Douglas Powell....

http://www.linkedin.com/pub/doug-powell/9/11b/756

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Something tells me that Ms. Kallinteris did not decide to leave Boston area for Tustin, CA just for the warmer weather, but more so for a Bavi global opportunity of a lifetime that is developing...

Senior Clinical Scientist, Clinical Affairs/Biomarkers Project Lead
Peregrine Pharmaceuticals
September 2013 – Present (3 months)

BAVITUXIMAB-Global Development
Translational Studies-Oncology Translational Medicine

http://www.linkedin.com/pub/nikoletta-lea-kallinteris/34/39a/212
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One possible path from Antigen Express to Peregrine... may be via Dr. George Peoples, one of the listed contributors here:

Sonia A. Perez PhD 1,
Eric von Hofe PhD 2,
Nikoletta L. Kallinteris MSCE 2,
Angelos D. Gritzapis PhD 1,
George E. Peoples MD 3,
Michael Papamichail MD, PhD 1,
Constantin N. Baxevanis PhD 1,

1 Cancer Immunology and Immunotherapy Center, St. Savas Cancer Hospital, Athens, Greece
2 Antigen Express Inc., Biotec III, Worcester, Massachusetts
3 Department of Surgery, General Surgery Service, Brooke Army Medical Center, Fort Sam Houston, Texas

http://onlinelibrary.wiley.com/doi/10.1002/cncr.24988/abstract
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Digging deeper.... how does one go from Worcester to Tustin? Now if you search enough you see "MANY" correlations here but I'll list one only because I'm sure you don't want to be reading much longer:

MD Anderson Cancer Center researcher Dr. Elizabeth A Mittendorf is the principal investigator and George E. Peoples from Brooke Army Medical Center is the Study Director of trial that is being funded and collaborated by San Antonio Military Medical Center, Norwell, Inc and Antigen Express, Inc.

http://bionews-tx.com/news/2013/10/07/us-military-opens-clinical-trials-for-breast-cancer-vaccine-internationally/

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Elizabeth A. Mittendorf

Dr. Mittendorf is an Assistant Professor in the Department of Surgical Oncology at the University of Texas MD Anderson Cancer Center. At MD Anderson, she focuses both her clinical and laboratory efforts on the study of breast cancer with a specific interest in breast cancer immunotherapy.

http://faculty.mdanderson.org/Elizabeth_Mittendorf/

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Now pay attention here...... Antigen Express is the subsidiary of "Generex" and notice the date June 12, 2013 below.... didn't Peregrine say those combination trials started in June? : )

Generex Announces Interview of MD Anderson's Dr. Elizabeth Mittendorf, Principal Investigator on Company's AE37 Phase IIb Breast Cancer Efficacy Trial

June 12, 2013

Finally, Dr. Mittendorf pointed to the possible real benefit of combining AE37 with other agents, such as immune checkpoint inhibitors. In particular, inhibitors of PD-1 (programmed cell death protein 1) or CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) have been shown to essentially take the brakes off the immune system, allowing it to more effectively combat tumor cells in a general way. As AE37 activates the immune system to specifically attack tumor cells, essentially "stepping on the gas", it is an exciting hypothesis to try combining them. It should be noted, however, that patients treated with AE37 alone also appear to have "taken the brakes off" the immune system to an extent.

http://finance.yahoo.com/news/generex-announces-interview-md-andersons-130000910.html

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There are many off-shoots to this entire line of events but I hope this was a clear view of at least how one from Worcester lands in Tustin - Antigen Express to Peregrine and we still have the Dr. Douglas Powell mystery of his info not being updated of where he is working... but we may find out eventually: and all of Big Pharma will soon realize that Bavi offers 200-300% response rates that downstreamers can't compete with! - and thats where the buyout behind door#3 will remain a possibility

As Peregrine releases more advancing data on the immune combination studies we should see more hints of the plus 200%-300% benefits to downstream immunotherapies that Dr. Brekken described.

http://investorshub.advfn.com/boards/read_msg.aspx?message_id=94181535&txt2find=dr|brekken|200|300