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Re: KMBJN post# 14608

Tuesday, 12/18/2012 6:02:12 PM

Tuesday, December 18, 2012 6:02:12 PM

Post# of 402069
Thanks for the info, but, rather than speculate, I contacted the company for an answer.

From Leo Ehrlich, in response to my question as to whether or not kevetrin is the same as CG200745.

All good compounds must work via multiple pathways as a cancer drug. Kevetrin acts primarily through regulating p53 activity.

Kevetrin is also HDAC-2 and HDAC-6 regulators, not an HDAC-2 or -6 inhibitor, as is the Crystal Genomics compound, or approved drugs, such as Vorinostat or Romidepsin.

Kevetrin has several other subordinate activities, such as, regulating c-myc activity, inducing apoptosis, etc.. We have also seen that Kevetrin has anti-angiogenic properties.



I'm glad we can put that to rest. ;)







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