Pacira Pharmaceuticals, Inc. (PCRX)

[surf1944]

6:32AM Pacira Pharma EXPAREL, as the foundation of a multimodal regimen, achieves statistical significance in all primary endpoints, including a 60% reduction in length of hospital stay (PCRX) 18.55 : Co announces topline results from the first completed IMPROVE study in its prospective Phase 4 clinical program. The study was designed to compare the difference in three primary endpoints, cost, opioid consumption and hospital length of stay, between one group of patients receiving a standard opioid-based postsurgical pain management regimen and a second group of patients receiving EXPAREL as the foundation of an opioid-sparing multimodal regimen. The EXPAREL-based multimodal regimen achieved a statistically significant reduction in each primary endpoint, including a 60% reduction in LOS in patients undergoing open colectomy, a surgical procedure to remove all or part of the colon through an incision in the abdominal wall. EXPAREL is a non-opioid local analgesic indicated for administration into the surgical site to produce postsurgical analgesia. The overall safety profile for EXPAREL was consistent with previous experiences in the Phase 3 program.