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Re: MiamiGent post# 497

Tuesday, 08/28/2012 7:27:21 AM

Tuesday, August 28, 2012 7:27:21 AM

Post# of 531
MDCO. before-open. Latest European Heart Attack Treatment Guidelines Recommend Angiomax(R)/Angiox(R) (Bivalirudin) Over Heparin
http://finance.yahoo.com/news/latest-european-heart-attack-treatment-050000838.html

MUNICH, GERMANY--(Marketwire -08/28/12)- Updated treatment guidelines presented by a leading European acute cardiology expert task force on the management of a severe form of heart attack called ST-segment elevation acute myocardial infarction (STEMI) recommend the use of bivalirudin (The Medicines Company (MDCO) trade name Angiox® in Europe and Angiomax® in North America and Asia) over heparin and a GP IIb/ IIIa blocker.

According to the guidelines, an anticoagulant "must be used" in patients undergoing primary percutaneous coronary intervention (PCI), an emergency lifesaving procedure used to unblock coronary arteries and restore blood flow to the heart muscle in a heart attack. The experts nominated Angiox as the Class I first choice "recommended over unfractionated heparin and a GP IIb/IIIa blocker."

The guidelines, presented as part of the European Society of Cardiology (ESC) annual congress in Munich this week, were developed by a 23 member expert Task Force on Myocardial Revascularization of the European Society of Cardiology. The guidelines provide recommendations for the management of heart attack patients from diagnosis to treatment, and are used by health care teams across Europe.

Bivalirudin was recognized by the expert panel as having both the highest strength of recommendation and level of evidence from clinical research (Class I, level of evidence B) of any intravenous antithrombotic listed in the updated guidelines.

Efthymios Deliargyris, MD, Global Medical Director for The Medicines Company, commented, "Over the last years, great strides have been made in the management of STEMI. Compared to a few years ago, thanks to advances in treatment techniques, technologies and medicines available for use in patients with STEMI, the risk of dying has been markedly reduced."

Cees Heiman, Senior Vice President and Regional Engagement Leader for Europe and the Middle East for The Medicines Company said, "Since the last guideline update in 2010, several milestones regarding Angiox and The Medicines Company in Europe have occurred. Most notably, in June 2011, The Lancet published the final three year results of a clinical trial called HORIZONS-AMI that was conducted globally in 3,602 STEMI patients undergoing primary PCI. We welcome these latest updates to the guidelines, as they will help health care teams make informed decisions in providing the best care for their patients."

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