Wednesday, August 15, 2012 7:38:52 PM
us about how the MOA has been updated to include exosomes. These very small vesicles are
released by the tumor and have PS on their surface. This PS is sensed by the macrophages and
dendritic cells which have PS receptors (TIM-3, TIM-4). This then causes an immunosuppresive
signal in those immune cells. When bavi is added it binds to the PS on the exosomes and the
Fc-gamma receptors on the immune effector cells. This send a immunostimulatory signal
to those immune cells. It is then the combination of the two signals which determines
what the immune response will be. The immunostimulatory signal over-rides the
immunosuppressive signal and the tumor microenvironment is changed to be immunostimulatory.
I drew this figure to show what is happening. This was the first time I have heard Thorpe
talk about exosomes in such detail. You can replace "exosome" with "tumor cell" also.
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