Tuesday, March 27, 2012 2:22:11 PM
List of studies showing anticancer and therapeutic effects of cannabinoids
Might be a good time to post this with more people watching.
BREAST CANCER
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
(full - 1998)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC20983/
Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation
(full - 2000)
http://endo.endojournals.org/cgi/content/full/141/1/118
Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells
(full - 2001)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222054/pdf/11485574.pdf/?tool=pmcentrez
Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
(full - 2006)
http://jpet.aspetjournals.org/content/318/3/1375.full
9-Tetrahydrocannabinol Inhibits Cell Cycle Progression in Human Breast Cancer through Cdc2 Regulation
(full - 2006)
http://cancerres.aacrjournals.org/cgi/content/full/66/13/6615
Anandamide inhibits adhesion and migration of breast cancer cells.
(abstract - 2006)
http://www.ncbi.nlm.nih.gov/pubmed/16343481?dopt=Abstract
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.
(full - 2007)
http://mct.aacrjournals.org/content/6/11/2921.long
Endocannabinoids in endocrine and related tumours
(full - 2008)
http://erc.endocrinology-journals.org/cgi/reprint/15/2/391.pdf
JunD is involved in the antiproliferative effect of Delta(9)-tetrahydrocannabinol on human breast cancer cells
(abstract - 2008)
http://www.knockoutscience.com/showabstract.php?pmid=18454173
Cannabinoid receptor agonists inhibit growth and metastasis of breast cancer
(abstract - 2008)
http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2008/1_Annual_Meeting/4081
Inhibition of Breast Cancer Aggressiveness by Cannabidiol
(abstract - 2008)
http://cbcrp.org.127.seekdotnet.com/research/PageGrant.asp?grant_id=4903
Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
(abstract - 2009)
http://mct.aacrjournals.org/content/8/11/3117.abstract
A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells.
(abstract - 2010)
http://www.ncbi.nlm.nih.gov/pubmed/20590578
BONE CANCER
Differential effects of repeated low dose treatment with the cannabinoid agonist WIN 55,212-2 in experimental models of bone cancer pain and neuropathic pain.
(abstract - 2008)
http://www.ncbi.nlm.nih.gov/pubmed/18611408
Reduction of bone cancer pain by activation of spinal cannabinoid receptor 1 and its expression in the superficial dorsal horn of the spinal cord in a murine model of bone cancer pain.
(full - 2009)
http://journals.lww.com/anesthesiology/Fulltext/2009/07000/Reduction_of_Bone_Cancer_Pain_by_Activation_of.31.aspx
Spinal and peripheral analgesic effects of the CB cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain.
(abstract - 2010)
http://www.ncbi.nlm.nih.gov/pubmed/20233215
A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss.
(abstract - 2010)
http://www.ncbi.nlm.nih.gov/pubmed/20176037
CERVICAL CANCER
Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1
(full - 2004)
http://science.iowamedicalmarijuana.org/pdfs/cancer/Contassot%202004.pdf
Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1
(full - 2008)
http://jnci.oxfordjournals.org/cgi/content/full/100/1/59
LIVER CANCER
Opposing Actions of Endocannabinoids on Cholangiocarcinoma Growth
(full - 2007)
http://www.jbc.org/content/282/17/13098.full
The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway
(full - 2008)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604798/?tool=pmcentrez
Recent advances in the regulation of cholangiocarcinoma growth
(full - 2010)
http://ajpgi.physiology.org/content/299/1/G1.full.pdf
COLORECTAL CANCER
Possible endocannabinoid control of colorectal cancer growth.
(abstract - 2003)
http://www.ncbi.nlm.nih.gov/pubmed/12949714
Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes.
(abstract - 2004)
http://www.ncbi.nlm.nih.gov/pubmed/16574988
The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2
(full - 2005)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774787/?tool=pmcentrez
Cannabinoids and cancer: potential for colorectal cancer therapy. (needs free registration)
(abstract - 2005)
http://www.medscape.com/medline/abstract/16042581
Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon
(full - 2007)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755791/
Cannabinoid Receptor Activation Induces Apoptosis through Tumor Necrosis Factor a–Mediated Ceramide De novo Synthesis in Colon Cancer Cells
(full - 2008)
http://clincancerres.aacrjournals.org/content/14/23/7691.full
Loss of cannabinoid receptor 1 accelerates intestinal tumor growth
(full - 2008)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561258/?tool=pubmed
Cannabinoids in intestinal inflammation and cancer
(full - 2009)
http://www.sciencedirect.com/science/article/pii/S1043661809000838
Induction of the antitumorigenic NSAID-activated gene (NAG-1) in synthetic hexahydrocannabinol-induced apoptosis of human colorectal cancer cells
(abstract - 2009)
http://www.fasebj.org/cgi/content/meeting_abstract/23/1_MeetingAbstracts/761.5
Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells
(abstract - 2010)
http://www.ncbi.nlm.nih.gov/pubmed/20230799
Involvement of NSAID-activated gene-1 in a novel synthetic hexahydrocannabinol analogue-induced growth inhibition and apoptosis of colon cancer cells
(abstract - 2010)
http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/965.8
STOMACH CANCER
The effect of cannnabinoid to gastric cancer
(abstract -2006)
http://www.aacrmeetingabstracts.org/cgi/content/abstract/2006/1/958-a
BRAIN CANCER
Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.
(abstract - 1998)
http://www.ncbi.nlm.nih.gov/pubmed/9771884
Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors
(full - 2000)
http://www.jbc.org/content/275/41/31938.full
Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation.
(abstract - 2000)
http://www.ncbi.nlm.nih.gov/pubmed/10700234
Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor1
(full - 2001)
http://cancerres.aacrjournals.org/cgi/reprint/61/15/5784.pdf
Inhibition of Rat C6 Glioma Cell Proliferation by Endogenous and Synthetic Cannabinoids. Relative Involvement of Cannabinoid and Vanilloid Receptors
(full - 2001)
http://jpet.aspetjournals.org/content/299/3/951.full
Inhibition of tumor angiogenesis by cannabinoids
(full - 2003)
http://www.fasebj.org/cgi/reprint/02-0795fjev1
Cannabinoids: Potential Anticancer Agents
(full - 2003)
http://americanmarijuana.org/Guzman-Cancer.pdf
Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
(full - 2003)
http://jpet.aspetjournals.org/content/308/3/838.long
Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(+)-Methanandamide-Induced Apoptotic Death of Human Neuroglioma Cells
(full - 2004)
http://science.iowamedicalmarijuana.org/pdfs/cancer/Hinz%202004.pdf
Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas
(full - 2004)
http://cancerres.aacrjournals.org/cgi/content/full/64/16/5617
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines.
(full - 2004)
http://science.iowamedicalmarijuana.org/pdfs/cancer/Massi%202004.pdf
Hypothesis: Cannabinoid Therapy for the Treatment of Gliomas?
(full - 2004)
http://hempirl.webs.com/The%20Compassionate%20Use%20of%20Medical%20Cannabis%20Act%202010/Velasco%20NP%202004%282%29.pdf
Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
(full - 2005)
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1576089&tool=pmcentrez
Endocannabinoid metabolism in human glioblastomas and meningiomas compared to human non-tumour brain tissue
(full - 2005)
http://www.ukcia.org/research/EndocannabinoidMetabolismInHumanGlioblastomasAndMeningiomas.pdf
Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells.
(abstract - 2005)
http://www.springerlink.com/content/m58jx46251w0287g/
A pilot clinical study of Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme.
(full - 2006)
http://www.nature.com/bjc/journal/v95/n2/full/6603236a.html
The non-psychoactive Cannabidiol triggers caspase activation and oxidative stress in human glioma cells.
(abstract - 2006)
http://www.springerlink.com/content/j204357070675797/
Cannabinoids Induce Glioma Stem-like Cell Differentiation
and Inhibit Gliomagenesis
(full - 2007)
http://www.jbc.org/content/282/9/6854.long
Expression of cannabinoid receptors and neurotrophins in human gliomas.
(abstract - 2007)
http://www.springerlink.com/content/d571738026861731/
Targeting astrocytomas and invading immune cells with cannabinoids: a promising therapeutic avenue.
(abstract - 2007)
http://www.springerlink.com/content/hku11676700hr12m/
Delta9-Tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells.
(full - 2007)
http://informahealthcare.com/doi/pdf/10.1080/02841860701678787
Cannabinoids and gliomas.
(full - 2007)
http://www.bbm1.ucm.es/cannabis/archivos/publicaciones/Mol_Neurobiol07_36_60_67.pdf
Cannabinoids Inhibit Glioma Cell Invasion by Down-regulating Matrix Metalloproteinase-2 Expression
(full - 2008)
http://cancerres.aacrjournals.org/cgi/content/full/68/6/1945
Cannabinoids as potential new therapy for the treatment of gliomas
(full - 2008)
http://safeaccess.ca/research/pdf/ParolaroCBasTherapyforGliomas2008.pdf
Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?
(full - 2008)
http://www.bbm1.ucm.es/cannabis/archivos/publicaciones/Neuropharmacology08_54_235_243.pdf
Cannabinoid action induces autophagymediated cell death through stimulation of ER stress in human glioma cells.
(full - 2009)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673842/?tool=pmcentrez
Cannabidiol Enhances the Inhibitory Effects of ?9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
(full - 2010)
http://www.letfreedomgrow.com/cmu/Brain_Cancer_Study.pdf
HEAD AND NECK CANCER
Marijuana use and Risk of Oral Squamous Cell Carcinoma
(full - 2004)
http://cancerres.aacrjournals.org/content/64/11/4049.full
Cannabis use and cancer of the head and neck: Case-control study
(full -2008)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277494/
A Population-Based Case-Control Study of Marijuana Use and Head and Neck Squamous Cell Carcinoma.
(full - 2009)
http://safeaccess.ca/research/pdf/MarijuanaUse_and_Head-NeckSquamousCellCarcinoma.pdf
KAPOSI'S SARCOMA
The CB1/CB2 receptor agonist WIN-55,212-2 reduces viability of human
Kaposi‘s sarcoma cells in vitro
(full - 2009)
http://science.iowamedicalmarijuana.org/pdfs/cancer/Luca%20et%20al%202009%2019539619.pdf
LEUKEMIA
Effects of cannabinoids on L1210 murine leukemia. 1. Inhibition of DNA synthesis.
(abstract - 1977)
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=897352&dopt=abstractplus
Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors
(full - 2000)
http://www.jbc.org/content/275/41/31938.full
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
(full - 2002)
http://bloodjournal.hematologylibrary.org/cgi/reprint/100/2/627.pdf
Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells.
(abstract - 2003)
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=14692532&dopt=abstractplus
Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway
(full - 2005)
http://bloodjournal.hematologylibrary.org/cgi/content/full/105/3/1214
Cannabidiol-Induced Apoptosis in Human Leukemia Cells : A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression
(full - 2006)
http://molpharm.aspetjournals.org/cgi/content/full/70/3/897
{Delta}9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria
(full - 2006)
http://mcr.aacrjournals.org/content/4/8/549.full
HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor
(full - 2007)
http://mct.aacrjournals.org/content/6/1/173.long
Enhancing the in vitro cytotoxic activity of Delta9-tetrahydrocannabinol in leukemic cells through a combinatorial approach
(abstract - 2008)
http://www.ncbi.nlm.nih.gov/pubmed/18608861
LUNG CANCER
A pilot study of orally administered ?1-trans-tetrahydrocannabinol in the management of patients undergoing radiotherapy for carcinoma of the bronchus
(full - 1974)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402430/?tool=pmcentrez&page=1
Antineoplastic activity of cannabinoids
(full - 1975)
http://www.ukcia.org/research/AntineoplasticActivityOfCannabinoids/default.html
In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas.
(abstract - 1977)
http://www.ncbi.nlm.nih.gov/pubmed/616322
Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.
(full - 1983)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011510/?tool=pmcentrez&page=1
Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers: Results of a Population-Based Case-Control Study
(full - 2006)
http://cebp.aacrjournals.org/content/15/10/1829.full
Marijuana Use and Lung Cancer: Results of a Case-Control Study
(abstract - 2006)
http://www.ukcia.org/research/MjUseAndLungCancer.php
{Delta}-9 Tetrahydrocannabinol inhibits growth and metastasis of lung cancer.
(abstract - 2007)
http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2007/1_Annual_Meeting/4749
Delta(9)-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
(abstract - 2007)
http://www.nature.com/onc/journal/v27/n3/abs/1210641a.html
Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1
(full - 2008)
http://jnci.oxfordjournals.org/cgi/content/full/100/1/59
Doubts about the role of cannabis in causing lung cancer.
(letter - 2008)
http://erj.ersjournals.com/cgi/content/full/32/3/815
LYMPHOMA
Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors
(full - 2000)
http://www.jbc.org/content/275/41/31938.full
The Peripheral Cannabinoid Receptor CB2 and CD40 Are Novel Biological Markers That Predict Outcome in Diffuse Large B-Cell Lymphoma of Elderly Patients.
(abstract - 2004)
http://abstracts.hematologylibrary.org/cgi/content/abstract/104/11/3256
Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma.
(abstract - 2005)
http://www.ncbi.nlm.nih.gov/pubmed/16337199?dopt=Abstract
Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma
(full - 2006)
http://molpharm.aspetjournals.org/content/70/5/1612.full
Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation.
(abstract - 2008)
http://www.ncbi.nlm.nih.gov/pubmed/18546271
NEUROBLASTOMA
Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors
(full - 2000)
http://www.jbc.org/content/275/41/31938.full
MOUTH CANCER
Boron trifluoride etherate on silica-A modified Lewis acid reagent (VII). Antitumor activity of cannabigerol against human oral epitheloid carcinoma cells.
(abstract - 1998)
http://www.ncbi.nlm.nih.gov/pubmed/9875457
Marijuana use and Risk of Oral Squamous Cell Carcinoma
(full - 2004)
http://cancerres.aacrjournals.org/content/64/11/4049.full
Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers: Results of a Population-Based Case-Control Study
(full - 2006)
http://cebp.aacrjournals.org/content/15/10/1829.full
Peripheral Cannabinoids Attenuate Carcinoma Induced Nociception in Mice
(full - 2008)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771220/
Cannabinoids Inhibit Cellular Respiration of Human Oral Cancer Cells
(abstract - 2010)
http://www.ncbi.nlm.nih.gov/pubmed/20516734
OVARIAN CANCER
Cannabinoid receptors as a target for therapy of ovarian cancer
(abstract - 2006)
http://www.aacrmeetingabstracts.org/cgi/content/abstract/2006/1/1084
PANCREATIC CANCER
Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress–Related Genes
(full - 2006)
http://cancerres.aacrjournals.org/cgi/content/full/66/13/6748
Cannabinoids in pancreatic cancer: Correlation with survival and pain
(full - 2008)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225529/?tool=pmcentrez
PITUITARY ADENOMA
Normal Human Pituitary Gland and Pituitary Adenomas Express Cannabinoid Receptor Type 1 and Synthesize Endogenous Cannabinoids: First Evidence for a Direct Role of Cannabinoids on Hormone Modulation at the Human Pituitary Level
(full - 2001)
http://jcem.endojournals.org/content/86/6/2687.full
PROSTATE CANCER
delta-9-Tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism
(abstract - 1999)
http://www.ncbi.nlm.nih.gov/pubmed/10570948
Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation
(full - 2000)
http://www.medicinalgenomics.com/wp-content/uploads/2011/07/Suppression-of-NGF-Trk-Receptors-and-Prolactin-Receptors-by-Endocannabinoids-inhibits-breast-and-prostrate-cancer-cell-growth.pdf
Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production.
(abstract - 2003)
http://www.ncbi.nlm.nih.gov/pubmed/12746841?dopt=Abstract
2-Arachidonoylglycerol A Novel Inhibitor of Androgen-Independent Prostate Cancer Cell Invasion
(full - 2004)
http://cancerres.aacrjournals.org/cgi/content/full/64/24/8826
Cannabinoid Receptor as a Novel Target for the Treatment of Prostate Cancer
(full - 2005)
http://cancerres.aacrjournals.org/cgi/reprint/65/5/1635.pdf
Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK1/2 Leading to G1 Cell Cycle Arrest
(full - 2006)
http://www.jbc.org/content/281/51/39480.full
Cannabinoid receptors agonist WIN-55,212-2 inhibits angiogenesis, metastasis and tumor growth of androgen-sensitive prostate cancer cell CWR22R{nu}1 xenograft in athymic nude mice
(abstract - 2007)
http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2007/1_Annual_Meeting/2195
Endocannabinoids in endocrine and related tumours
(full - 2008)
http://erc.endocrinology-journals.org/cgi/reprint/15/2/391.pdf
Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: Involvement of CB2
(full - 2009)
http://www.nature.com/bjc/journal/v101/n6/full/6605248a.html
CANCER RISK TOBACCO VS CANNABIS
Cannabis and tobacco smoke are not equally carcinogenic
(full - 2005)
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1277837
On the Carcinogenity of Marijuana Smoke
(transcribed part - 1975)
http://www.marijuana.com/threads/on-the-carcinogenicity-of-marijuana-smoke.245844/
Cannabis Vaporizer Combines Efficient Delivery of THC with Effective Suppression of Pyrolytic Compounds
(full - 2004)
http://www.safeaccessnow.org/downloads/Vaporizer_Study.pdf
Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer
(full - 2003)
http://www.jci.org/articles/view/17492
SKIN CANCER
Intractable nausea and vomiting due to gastrointestinal mucosal metastases
(abstract - 1997)
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=35
Cannabinoid receptors as novel targets for the treatment of melanoma
(full - 2006)
http://www.fasebj.org/cgi/content/full/20/14/2633
Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.
(abstract - 2006)
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=180
Cannabinoid receptor-1 modulation induces apoptosis of human melanoma cells
(abstract - 2008)
http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2008/1_Annual_Meeting/2678
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
(full - 2003)
http://www.jci.org/cgi/content/full/111/1/43?ijkey=MpUgjDbqHybAU
TESTICULAR CANCER
Crossover comparison of the antiemetic efficacy of nabilone and alizapride in patients with nonseminomatous testicular cancer receiving cisplatin therapy
(abstract - 1986)
http://www.ncbi.nlm.nih.gov/pubmed/3009962
THYROID CANCER
Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth
(full - 2001)
http://www.fasebj.org/content/15/14/2745.full
Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis1
(full - 2003)
http://www.fasebj.org/content/17/12/1771.full.pdf
Endocannabinoids in endocrine and related tumours
(full - 2008)
http://erc.endocrinology-journals.org/cgi/reprint/15/2/391.pdf
Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma.
(abstract + introduction - 2008)
http://business.highbeam.com/437444/article-1G1-186436843/cannabinoid-2-receptor-induction-il12-and-its-potential
A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis
(abstract - 2009)
http://www.ncbi.nlm.nih.gov/pubmed/19189054
DIVERSE, CANCER RELATED
Analgesic effect of delta-9-tetrahydrocannabinol.
(full - 1975)
http://www.druglibrary.org/crl/pain/Noyes%20et.al%2075%20Analgesic%20Effect%20JClinPharmac.pdf
Delta-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate A prospective, randomized evaluation
(abstract - 1979)
http://www.annals.org/content/91/6/819.abstract
Delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy; a double-blind cross-over trial against placebo
(full transcribed - 1979)
http://www.ukcia.org/research/antiemetic.php
Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9--tetrahydrocannabinol.
(full transcribed -1979)
http://www.myspace.com/ldsmmj/blog/517704966
Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy.
(abstract - 1979)
http://www.ncbi.nlm.nih.gov/pubmed/375088
A multi-institutional Phase III study of nabilone vs. placebo in chemotherapy-induced nausea and vomiting.
(abstract - 1982)
http://www.sciencedirect.com/science/article/pii/S0305737282800352
Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis
(page 1 - 1986)
http://resources.metapress.com/pdf-preview.axd?code=qp24657820k65r82&size=largest
Inhalation marijuana as an antiemetic for cancer chemotherapy.
(full transcribed - 1988)
http://www.omma1998.org/omr_vinciguerra.html
Efficacy of tetrahydrocannabinol in patients refractory to standard anti-emetic therapy
(page 1 - 1988)
http://resources.metapress.com/pdf-preview.axd?code=k3146279x826241v&size=largest
Dronabinol enhancement of appetite in cancer patients.
(abstract - 1990)
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=149
Dronabinol and prochlorperazine in combination for treatment of cancer chemotherapy-induced nausea and vomiting.
(abstract - 1991)
http://www.ncbi.nlm.nih.gov/pubmed/1652611
A phase II study of delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia
(abstract -1994)
http://www.ncbi.nlm.nih.gov/pubmed/8035251
Therapeutic Aspects of Cannabis and Cannabinoids
(full - 2001)
http://bjp.rcpsych.org/cgi/reprint/178/2/107.pdf
Targeting the endocannabinoid system in cancer therapy: A call for further research
(full - 2002)
http://www.fuoriluogo.it/medicalcannabis/documenti/bifulco2002.pdf
Endocannabinoids in the immune system and cancer.
(abstract - 2002)
http://www.ncbi.nlm.nih.gov/pubmed/12052046
Cannabinoids: Potential Anticancer Agents
(full - 2003)
http://americanmarijuana.org/Guzman-Cancer.pdf
Inhibition of tumor angiogenesis by cannabinoids
(full - 2003)
http://www.fasebj.org/content/early/2003/03/02/fj.02-0795fje.full.pdf
Established and potential therapeutic applications of cannabinoids in oncology
(page 1 - 2003)
http://resources.metapress.com/pdf-preview.axd?code=py9cunbm343und5v&size=largest
The effects of smoked cannabis in painful peripheral neuropathy and cancer pain refractory to opioids
(full - 2003)
http://www.cmcr.ucsd.edu/images/pdfs/Abrams_abs_4.pdf
Cannabinoid receptor systems: therapeutic targets for tumour intervention
(abstract - 2003)
http://informahealthcare.com/doi/abs/10.1517/14728222.7.6.749
Cannabinoids and cancer: pros and cons of an antitumour strategy
(full - 2006)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617062/?tool=pmcentrez
Different views on the relationship between cannabinoids and cancer
(full - 2006)
http://nts.prolekare.cz/cls/odkazy/clc0606-453.pdf
The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients
(abstract - 2006)
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=177
A Cannabinoid Anticancer Quinone, HU-331, Is More Potent and Less Cardiotoxic Than Doxorubicin: A Comparative in Vivo Study
(full - 2007)
http://jpet.aspetjournals.org/content/322/2/646.full
Sativex: Fact Sheet
(full - 2007)
http://www.bayer.ca/files/sativex_fs_fd_109461_e%20_GW_.pdf
Cannabinoids for Cancer Treatment: Progress and Promise
(full - 2008)
http://cancerres.aacrjournals.org/cgi/content/full/68/2/339
Changes in the Endocannabinoid System May Give Insight into new and Effective Treatments for Cancer
(full - 2009)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791688/?tool=pmcentrez
Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents.
(full - 2009)
http://www.fondazionezardigori.com/1/upload/pisanti_2009.pdf
Hexahydrocannabinols, novel synthetic cannabinoid derivatives, suppress the tumor growth by inhibiting the VEGF secretion and angiogenesis
(abstract - 2009)
http://www.fasebj.org/cgi/content/meeting_abstract/23/1_MeetingAbstracts/761.3
Cannabinoid receptor ligands as potential anticancer agents--high hopes for new therapies?
(full - 2009)
http://www.fondazionezardigori.com/1/upload/oesch_gertsch_2009.pdf
Cannabinoids in the treatment of cancer
(full - 2009)
http://www.phillynorml.org/documents/legis_files/09_Rosengren_Review%20of%20anticancer%20cannabinoids_Cancerletters.pdf
Targeting the Endocannabinoid System for the Treatment of Cancer - A Practical View.
(abstract - 2010)
http://www.ncbi.nlm.nih.gov/pubmed/20370711?dopt=Abstract
Might be a good time to post this with more people watching.
BREAST CANCER
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
(full - 1998)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC20983/
Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation
(full - 2000)
http://endo.endojournals.org/cgi/content/full/141/1/118
Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells
(full - 2001)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222054/pdf/11485574.pdf/?tool=pmcentrez
Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
(full - 2006)
http://jpet.aspetjournals.org/content/318/3/1375.full
9-Tetrahydrocannabinol Inhibits Cell Cycle Progression in Human Breast Cancer through Cdc2 Regulation
(full - 2006)
http://cancerres.aacrjournals.org/cgi/content/full/66/13/6615
Anandamide inhibits adhesion and migration of breast cancer cells.
(abstract - 2006)
http://www.ncbi.nlm.nih.gov/pubmed/16343481?dopt=Abstract
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.
(full - 2007)
http://mct.aacrjournals.org/content/6/11/2921.long
Endocannabinoids in endocrine and related tumours
(full - 2008)
http://erc.endocrinology-journals.org/cgi/reprint/15/2/391.pdf
JunD is involved in the antiproliferative effect of Delta(9)-tetrahydrocannabinol on human breast cancer cells
(abstract - 2008)
http://www.knockoutscience.com/showabstract.php?pmid=18454173
Cannabinoid receptor agonists inhibit growth and metastasis of breast cancer
(abstract - 2008)
http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2008/1_Annual_Meeting/4081
Inhibition of Breast Cancer Aggressiveness by Cannabidiol
(abstract - 2008)
http://cbcrp.org.127.seekdotnet.com/research/PageGrant.asp?grant_id=4903
Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
(abstract - 2009)
http://mct.aacrjournals.org/content/8/11/3117.abstract
A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells.
(abstract - 2010)
http://www.ncbi.nlm.nih.gov/pubmed/20590578
BONE CANCER
Differential effects of repeated low dose treatment with the cannabinoid agonist WIN 55,212-2 in experimental models of bone cancer pain and neuropathic pain.
(abstract - 2008)
http://www.ncbi.nlm.nih.gov/pubmed/18611408
Reduction of bone cancer pain by activation of spinal cannabinoid receptor 1 and its expression in the superficial dorsal horn of the spinal cord in a murine model of bone cancer pain.
(full - 2009)
http://journals.lww.com/anesthesiology/Fulltext/2009/07000/Reduction_of_Bone_Cancer_Pain_by_Activation_of.31.aspx
Spinal and peripheral analgesic effects of the CB cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain.
(abstract - 2010)
http://www.ncbi.nlm.nih.gov/pubmed/20233215
A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss.
(abstract - 2010)
http://www.ncbi.nlm.nih.gov/pubmed/20176037
CERVICAL CANCER
Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1
(full - 2004)
http://science.iowamedicalmarijuana.org/pdfs/cancer/Contassot%202004.pdf
Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1
(full - 2008)
http://jnci.oxfordjournals.org/cgi/content/full/100/1/59
LIVER CANCER
Opposing Actions of Endocannabinoids on Cholangiocarcinoma Growth
(full - 2007)
http://www.jbc.org/content/282/17/13098.full
The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway
(full - 2008)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604798/?tool=pmcentrez
Recent advances in the regulation of cholangiocarcinoma growth
(full - 2010)
http://ajpgi.physiology.org/content/299/1/G1.full.pdf
COLORECTAL CANCER
Possible endocannabinoid control of colorectal cancer growth.
(abstract - 2003)
http://www.ncbi.nlm.nih.gov/pubmed/12949714
Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes.
(abstract - 2004)
http://www.ncbi.nlm.nih.gov/pubmed/16574988
The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2
(full - 2005)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774787/?tool=pmcentrez
Cannabinoids and cancer: potential for colorectal cancer therapy. (needs free registration)
(abstract - 2005)
http://www.medscape.com/medline/abstract/16042581
Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon
(full - 2007)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755791/
Cannabinoid Receptor Activation Induces Apoptosis through Tumor Necrosis Factor a–Mediated Ceramide De novo Synthesis in Colon Cancer Cells
(full - 2008)
http://clincancerres.aacrjournals.org/content/14/23/7691.full
Loss of cannabinoid receptor 1 accelerates intestinal tumor growth
(full - 2008)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561258/?tool=pubmed
Cannabinoids in intestinal inflammation and cancer
(full - 2009)
http://www.sciencedirect.com/science/article/pii/S1043661809000838
Induction of the antitumorigenic NSAID-activated gene (NAG-1) in synthetic hexahydrocannabinol-induced apoptosis of human colorectal cancer cells
(abstract - 2009)
http://www.fasebj.org/cgi/content/meeting_abstract/23/1_MeetingAbstracts/761.5
Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells
(abstract - 2010)
http://www.ncbi.nlm.nih.gov/pubmed/20230799
Involvement of NSAID-activated gene-1 in a novel synthetic hexahydrocannabinol analogue-induced growth inhibition and apoptosis of colon cancer cells
(abstract - 2010)
http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/965.8
STOMACH CANCER
The effect of cannnabinoid to gastric cancer
(abstract -2006)
http://www.aacrmeetingabstracts.org/cgi/content/abstract/2006/1/958-a
BRAIN CANCER
Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.
(abstract - 1998)
http://www.ncbi.nlm.nih.gov/pubmed/9771884
Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors
(full - 2000)
http://www.jbc.org/content/275/41/31938.full
Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation.
(abstract - 2000)
http://www.ncbi.nlm.nih.gov/pubmed/10700234
Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor1
(full - 2001)
http://cancerres.aacrjournals.org/cgi/reprint/61/15/5784.pdf
Inhibition of Rat C6 Glioma Cell Proliferation by Endogenous and Synthetic Cannabinoids. Relative Involvement of Cannabinoid and Vanilloid Receptors
(full - 2001)
http://jpet.aspetjournals.org/content/299/3/951.full
Inhibition of tumor angiogenesis by cannabinoids
(full - 2003)
http://www.fasebj.org/cgi/reprint/02-0795fjev1
Cannabinoids: Potential Anticancer Agents
(full - 2003)
http://americanmarijuana.org/Guzman-Cancer.pdf
Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
(full - 2003)
http://jpet.aspetjournals.org/content/308/3/838.long
Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(+)-Methanandamide-Induced Apoptotic Death of Human Neuroglioma Cells
(full - 2004)
http://science.iowamedicalmarijuana.org/pdfs/cancer/Hinz%202004.pdf
Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas
(full - 2004)
http://cancerres.aacrjournals.org/cgi/content/full/64/16/5617
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines.
(full - 2004)
http://science.iowamedicalmarijuana.org/pdfs/cancer/Massi%202004.pdf
Hypothesis: Cannabinoid Therapy for the Treatment of Gliomas?
(full - 2004)
http://hempirl.webs.com/The%20Compassionate%20Use%20of%20Medical%20Cannabis%20Act%202010/Velasco%20NP%202004%282%29.pdf
Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
(full - 2005)
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1576089&tool=pmcentrez
Endocannabinoid metabolism in human glioblastomas and meningiomas compared to human non-tumour brain tissue
(full - 2005)
http://www.ukcia.org/research/EndocannabinoidMetabolismInHumanGlioblastomasAndMeningiomas.pdf
Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells.
(abstract - 2005)
http://www.springerlink.com/content/m58jx46251w0287g/
A pilot clinical study of Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme.
(full - 2006)
http://www.nature.com/bjc/journal/v95/n2/full/6603236a.html
The non-psychoactive Cannabidiol triggers caspase activation and oxidative stress in human glioma cells.
(abstract - 2006)
http://www.springerlink.com/content/j204357070675797/
Cannabinoids Induce Glioma Stem-like Cell Differentiation
and Inhibit Gliomagenesis
(full - 2007)
http://www.jbc.org/content/282/9/6854.long
Expression of cannabinoid receptors and neurotrophins in human gliomas.
(abstract - 2007)
http://www.springerlink.com/content/d571738026861731/
Targeting astrocytomas and invading immune cells with cannabinoids: a promising therapeutic avenue.
(abstract - 2007)
http://www.springerlink.com/content/hku11676700hr12m/
Delta9-Tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells.
(full - 2007)
http://informahealthcare.com/doi/pdf/10.1080/02841860701678787
Cannabinoids and gliomas.
(full - 2007)
http://www.bbm1.ucm.es/cannabis/archivos/publicaciones/Mol_Neurobiol07_36_60_67.pdf
Cannabinoids Inhibit Glioma Cell Invasion by Down-regulating Matrix Metalloproteinase-2 Expression
(full - 2008)
http://cancerres.aacrjournals.org/cgi/content/full/68/6/1945
Cannabinoids as potential new therapy for the treatment of gliomas
(full - 2008)
http://safeaccess.ca/research/pdf/ParolaroCBasTherapyforGliomas2008.pdf
Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?
(full - 2008)
http://www.bbm1.ucm.es/cannabis/archivos/publicaciones/Neuropharmacology08_54_235_243.pdf
Cannabinoid action induces autophagymediated cell death through stimulation of ER stress in human glioma cells.
(full - 2009)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673842/?tool=pmcentrez
Cannabidiol Enhances the Inhibitory Effects of ?9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
(full - 2010)
http://www.letfreedomgrow.com/cmu/Brain_Cancer_Study.pdf
HEAD AND NECK CANCER
Marijuana use and Risk of Oral Squamous Cell Carcinoma
(full - 2004)
http://cancerres.aacrjournals.org/content/64/11/4049.full
Cannabis use and cancer of the head and neck: Case-control study
(full -2008)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277494/
A Population-Based Case-Control Study of Marijuana Use and Head and Neck Squamous Cell Carcinoma.
(full - 2009)
http://safeaccess.ca/research/pdf/MarijuanaUse_and_Head-NeckSquamousCellCarcinoma.pdf
KAPOSI'S SARCOMA
The CB1/CB2 receptor agonist WIN-55,212-2 reduces viability of human
Kaposi‘s sarcoma cells in vitro
(full - 2009)
http://science.iowamedicalmarijuana.org/pdfs/cancer/Luca%20et%20al%202009%2019539619.pdf
LEUKEMIA
Effects of cannabinoids on L1210 murine leukemia. 1. Inhibition of DNA synthesis.
(abstract - 1977)
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=897352&dopt=abstractplus
Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors
(full - 2000)
http://www.jbc.org/content/275/41/31938.full
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
(full - 2002)
http://bloodjournal.hematologylibrary.org/cgi/reprint/100/2/627.pdf
Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells.
(abstract - 2003)
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=14692532&dopt=abstractplus
Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway
(full - 2005)
http://bloodjournal.hematologylibrary.org/cgi/content/full/105/3/1214
Cannabidiol-Induced Apoptosis in Human Leukemia Cells : A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression
(full - 2006)
http://molpharm.aspetjournals.org/cgi/content/full/70/3/897
{Delta}9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria
(full - 2006)
http://mcr.aacrjournals.org/content/4/8/549.full
HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor
(full - 2007)
http://mct.aacrjournals.org/content/6/1/173.long
Enhancing the in vitro cytotoxic activity of Delta9-tetrahydrocannabinol in leukemic cells through a combinatorial approach
(abstract - 2008)
http://www.ncbi.nlm.nih.gov/pubmed/18608861
LUNG CANCER
A pilot study of orally administered ?1-trans-tetrahydrocannabinol in the management of patients undergoing radiotherapy for carcinoma of the bronchus
(full - 1974)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402430/?tool=pmcentrez&page=1
Antineoplastic activity of cannabinoids
(full - 1975)
http://www.ukcia.org/research/AntineoplasticActivityOfCannabinoids/default.html
In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas.
(abstract - 1977)
http://www.ncbi.nlm.nih.gov/pubmed/616322
Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.
(full - 1983)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011510/?tool=pmcentrez&page=1
Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers: Results of a Population-Based Case-Control Study
(full - 2006)
http://cebp.aacrjournals.org/content/15/10/1829.full
Marijuana Use and Lung Cancer: Results of a Case-Control Study
(abstract - 2006)
http://www.ukcia.org/research/MjUseAndLungCancer.php
{Delta}-9 Tetrahydrocannabinol inhibits growth and metastasis of lung cancer.
(abstract - 2007)
http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2007/1_Annual_Meeting/4749
Delta(9)-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
(abstract - 2007)
http://www.nature.com/onc/journal/v27/n3/abs/1210641a.html
Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1
(full - 2008)
http://jnci.oxfordjournals.org/cgi/content/full/100/1/59
Doubts about the role of cannabis in causing lung cancer.
(letter - 2008)
http://erj.ersjournals.com/cgi/content/full/32/3/815
LYMPHOMA
Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors
(full - 2000)
http://www.jbc.org/content/275/41/31938.full
The Peripheral Cannabinoid Receptor CB2 and CD40 Are Novel Biological Markers That Predict Outcome in Diffuse Large B-Cell Lymphoma of Elderly Patients.
(abstract - 2004)
http://abstracts.hematologylibrary.org/cgi/content/abstract/104/11/3256
Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma.
(abstract - 2005)
http://www.ncbi.nlm.nih.gov/pubmed/16337199?dopt=Abstract
Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma
(full - 2006)
http://molpharm.aspetjournals.org/content/70/5/1612.full
Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation.
(abstract - 2008)
http://www.ncbi.nlm.nih.gov/pubmed/18546271
NEUROBLASTOMA
Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors
(full - 2000)
http://www.jbc.org/content/275/41/31938.full
MOUTH CANCER
Boron trifluoride etherate on silica-A modified Lewis acid reagent (VII). Antitumor activity of cannabigerol against human oral epitheloid carcinoma cells.
(abstract - 1998)
http://www.ncbi.nlm.nih.gov/pubmed/9875457
Marijuana use and Risk of Oral Squamous Cell Carcinoma
(full - 2004)
http://cancerres.aacrjournals.org/content/64/11/4049.full
Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers: Results of a Population-Based Case-Control Study
(full - 2006)
http://cebp.aacrjournals.org/content/15/10/1829.full
Peripheral Cannabinoids Attenuate Carcinoma Induced Nociception in Mice
(full - 2008)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771220/
Cannabinoids Inhibit Cellular Respiration of Human Oral Cancer Cells
(abstract - 2010)
http://www.ncbi.nlm.nih.gov/pubmed/20516734
OVARIAN CANCER
Cannabinoid receptors as a target for therapy of ovarian cancer
(abstract - 2006)
http://www.aacrmeetingabstracts.org/cgi/content/abstract/2006/1/1084
PANCREATIC CANCER
Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress–Related Genes
(full - 2006)
http://cancerres.aacrjournals.org/cgi/content/full/66/13/6748
Cannabinoids in pancreatic cancer: Correlation with survival and pain
(full - 2008)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225529/?tool=pmcentrez
PITUITARY ADENOMA
Normal Human Pituitary Gland and Pituitary Adenomas Express Cannabinoid Receptor Type 1 and Synthesize Endogenous Cannabinoids: First Evidence for a Direct Role of Cannabinoids on Hormone Modulation at the Human Pituitary Level
(full - 2001)
http://jcem.endojournals.org/content/86/6/2687.full
PROSTATE CANCER
delta-9-Tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism
(abstract - 1999)
http://www.ncbi.nlm.nih.gov/pubmed/10570948
Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation
(full - 2000)
http://www.medicinalgenomics.com/wp-content/uploads/2011/07/Suppression-of-NGF-Trk-Receptors-and-Prolactin-Receptors-by-Endocannabinoids-inhibits-breast-and-prostrate-cancer-cell-growth.pdf
Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production.
(abstract - 2003)
http://www.ncbi.nlm.nih.gov/pubmed/12746841?dopt=Abstract
2-Arachidonoylglycerol A Novel Inhibitor of Androgen-Independent Prostate Cancer Cell Invasion
(full - 2004)
http://cancerres.aacrjournals.org/cgi/content/full/64/24/8826
Cannabinoid Receptor as a Novel Target for the Treatment of Prostate Cancer
(full - 2005)
http://cancerres.aacrjournals.org/cgi/reprint/65/5/1635.pdf
Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK1/2 Leading to G1 Cell Cycle Arrest
(full - 2006)
http://www.jbc.org/content/281/51/39480.full
Cannabinoid receptors agonist WIN-55,212-2 inhibits angiogenesis, metastasis and tumor growth of androgen-sensitive prostate cancer cell CWR22R{nu}1 xenograft in athymic nude mice
(abstract - 2007)
http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2007/1_Annual_Meeting/2195
Endocannabinoids in endocrine and related tumours
(full - 2008)
http://erc.endocrinology-journals.org/cgi/reprint/15/2/391.pdf
Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: Involvement of CB2
(full - 2009)
http://www.nature.com/bjc/journal/v101/n6/full/6605248a.html
CANCER RISK TOBACCO VS CANNABIS
Cannabis and tobacco smoke are not equally carcinogenic
(full - 2005)
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1277837
On the Carcinogenity of Marijuana Smoke
(transcribed part - 1975)
http://www.marijuana.com/threads/on-the-carcinogenicity-of-marijuana-smoke.245844/
Cannabis Vaporizer Combines Efficient Delivery of THC with Effective Suppression of Pyrolytic Compounds
(full - 2004)
http://www.safeaccessnow.org/downloads/Vaporizer_Study.pdf
Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer
(full - 2003)
http://www.jci.org/articles/view/17492
SKIN CANCER
Intractable nausea and vomiting due to gastrointestinal mucosal metastases
(abstract - 1997)
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=35
Cannabinoid receptors as novel targets for the treatment of melanoma
(full - 2006)
http://www.fasebj.org/cgi/content/full/20/14/2633
Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.
(abstract - 2006)
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=180
Cannabinoid receptor-1 modulation induces apoptosis of human melanoma cells
(abstract - 2008)
http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2008/1_Annual_Meeting/2678
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
(full - 2003)
http://www.jci.org/cgi/content/full/111/1/43?ijkey=MpUgjDbqHybAU
TESTICULAR CANCER
Crossover comparison of the antiemetic efficacy of nabilone and alizapride in patients with nonseminomatous testicular cancer receiving cisplatin therapy
(abstract - 1986)
http://www.ncbi.nlm.nih.gov/pubmed/3009962
THYROID CANCER
Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth
(full - 2001)
http://www.fasebj.org/content/15/14/2745.full
Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis1
(full - 2003)
http://www.fasebj.org/content/17/12/1771.full.pdf
Endocannabinoids in endocrine and related tumours
(full - 2008)
http://erc.endocrinology-journals.org/cgi/reprint/15/2/391.pdf
Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma.
(abstract + introduction - 2008)
http://business.highbeam.com/437444/article-1G1-186436843/cannabinoid-2-receptor-induction-il12-and-its-potential
A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis
(abstract - 2009)
http://www.ncbi.nlm.nih.gov/pubmed/19189054
DIVERSE, CANCER RELATED
Analgesic effect of delta-9-tetrahydrocannabinol.
(full - 1975)
http://www.druglibrary.org/crl/pain/Noyes%20et.al%2075%20Analgesic%20Effect%20JClinPharmac.pdf
Delta-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate A prospective, randomized evaluation
(abstract - 1979)
http://www.annals.org/content/91/6/819.abstract
Delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy; a double-blind cross-over trial against placebo
(full transcribed - 1979)
http://www.ukcia.org/research/antiemetic.php
Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9--tetrahydrocannabinol.
(full transcribed -1979)
http://www.myspace.com/ldsmmj/blog/517704966
Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy.
(abstract - 1979)
http://www.ncbi.nlm.nih.gov/pubmed/375088
A multi-institutional Phase III study of nabilone vs. placebo in chemotherapy-induced nausea and vomiting.
(abstract - 1982)
http://www.sciencedirect.com/science/article/pii/S0305737282800352
Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis
(page 1 - 1986)
http://resources.metapress.com/pdf-preview.axd?code=qp24657820k65r82&size=largest
Inhalation marijuana as an antiemetic for cancer chemotherapy.
(full transcribed - 1988)
http://www.omma1998.org/omr_vinciguerra.html
Efficacy of tetrahydrocannabinol in patients refractory to standard anti-emetic therapy
(page 1 - 1988)
http://resources.metapress.com/pdf-preview.axd?code=k3146279x826241v&size=largest
Dronabinol enhancement of appetite in cancer patients.
(abstract - 1990)
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=149
Dronabinol and prochlorperazine in combination for treatment of cancer chemotherapy-induced nausea and vomiting.
(abstract - 1991)
http://www.ncbi.nlm.nih.gov/pubmed/1652611
A phase II study of delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia
(abstract -1994)
http://www.ncbi.nlm.nih.gov/pubmed/8035251
Therapeutic Aspects of Cannabis and Cannabinoids
(full - 2001)
http://bjp.rcpsych.org/cgi/reprint/178/2/107.pdf
Targeting the endocannabinoid system in cancer therapy: A call for further research
(full - 2002)
http://www.fuoriluogo.it/medicalcannabis/documenti/bifulco2002.pdf
Endocannabinoids in the immune system and cancer.
(abstract - 2002)
http://www.ncbi.nlm.nih.gov/pubmed/12052046
Cannabinoids: Potential Anticancer Agents
(full - 2003)
http://americanmarijuana.org/Guzman-Cancer.pdf
Inhibition of tumor angiogenesis by cannabinoids
(full - 2003)
http://www.fasebj.org/content/early/2003/03/02/fj.02-0795fje.full.pdf
Established and potential therapeutic applications of cannabinoids in oncology
(page 1 - 2003)
http://resources.metapress.com/pdf-preview.axd?code=py9cunbm343und5v&size=largest
The effects of smoked cannabis in painful peripheral neuropathy and cancer pain refractory to opioids
(full - 2003)
http://www.cmcr.ucsd.edu/images/pdfs/Abrams_abs_4.pdf
Cannabinoid receptor systems: therapeutic targets for tumour intervention
(abstract - 2003)
http://informahealthcare.com/doi/abs/10.1517/14728222.7.6.749
Cannabinoids and cancer: pros and cons of an antitumour strategy
(full - 2006)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617062/?tool=pmcentrez
Different views on the relationship between cannabinoids and cancer
(full - 2006)
http://nts.prolekare.cz/cls/odkazy/clc0606-453.pdf
The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients
(abstract - 2006)
http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=177
A Cannabinoid Anticancer Quinone, HU-331, Is More Potent and Less Cardiotoxic Than Doxorubicin: A Comparative in Vivo Study
(full - 2007)
http://jpet.aspetjournals.org/content/322/2/646.full
Sativex: Fact Sheet
(full - 2007)
http://www.bayer.ca/files/sativex_fs_fd_109461_e%20_GW_.pdf
Cannabinoids for Cancer Treatment: Progress and Promise
(full - 2008)
http://cancerres.aacrjournals.org/cgi/content/full/68/2/339
Changes in the Endocannabinoid System May Give Insight into new and Effective Treatments for Cancer
(full - 2009)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791688/?tool=pmcentrez
Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents.
(full - 2009)
http://www.fondazionezardigori.com/1/upload/pisanti_2009.pdf
Hexahydrocannabinols, novel synthetic cannabinoid derivatives, suppress the tumor growth by inhibiting the VEGF secretion and angiogenesis
(abstract - 2009)
http://www.fasebj.org/cgi/content/meeting_abstract/23/1_MeetingAbstracts/761.3
Cannabinoid receptor ligands as potential anticancer agents--high hopes for new therapies?
(full - 2009)
http://www.fondazionezardigori.com/1/upload/oesch_gertsch_2009.pdf
Cannabinoids in the treatment of cancer
(full - 2009)
http://www.phillynorml.org/documents/legis_files/09_Rosengren_Review%20of%20anticancer%20cannabinoids_Cancerletters.pdf
Targeting the Endocannabinoid System for the Treatment of Cancer - A Practical View.
(abstract - 2010)
http://www.ncbi.nlm.nih.gov/pubmed/20370711?dopt=Abstract
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