Inovio Pharmaceuticals Inc (INO)

[Ubertino]

(WO2011137221) ORAL MUCOSAL ELECTROPORATION DEVICE AND USE THEREOF


Pub. No.:
WO/2011/137221

International Application No.:
PCT/US2011/034277

Publication Date:
03.11.2011

International Filing Date:
28.04.2011

Applicants:
INOVIO PHARMACEUTICALS, INC. [US/US]; 1787 Sentry Parkway West Building 18, Suite 400 Blue Bell, Pennsylvania 19422 (US) (For All Designated States Except US).
KEMMERRER, Stephen V. [US/US]; (US) (For US Only).
MCCOY, Jay [US/US]; (US) (For US Only).
BRODERICK, Kate [GB/US]; (US) (For US Only)

Inventors:
KEMMERRER, Stephen V.; (US).
MCCOY, Jay; (US).
BRODERICK, Kate; (US)
Agent: KIM, Thomas S.; Inovio Pharmaceuticals, Inc. 1787 Sentry Parkway West Building 18, Suite 400 Blue Bell, Pennsylvania 19422 (US)

Priority Data:
61/328,868 28.04.2010 US

Title (EN) ORAL MUCOSAL ELECTROPORATION DEVICE AND USE THEREOF
(FR) DISPOSITIF D'ÉLECTROPORATION À USAGE ORAL, APPLIQUÉ À UNE MUQUEUSE, ET SON UTILISATION

Abstract:
(EN)The present invention relates to oral electroporation (EP) devices that are able to generate an electroporation causing electrical field at the mucosal layer, and preferably in a tolerable manner. Further, it includes the generation of a protective immune response, cellular and/or humoral, using the oral EP device along with a genetic construct that encodes an immunogenic sequence.

Summary of the Invention

There are provided electroporation devices capable of electroporating cells of a mucosal membrane of a mammal. Such devices include an electrode microneedle plate, a counter electrode plate, a main housing and an energy source. The main housing is in physical communication with said microneedle plate and counter electrode plate, wherein the main house is in fluid communication with a syringe capable of storing a pharmaceutical formulation for delivery. The energy source is in electrical communication with the microneedle plate and capable of generating an electric potential and delivering the electric potential to the cells through the microneedle plate.

http://is.gd/RrHVLX

See Fig. 17 for cheek electroporation device.
http://www.wipo.int/patentscope/search/docservicepdf_pct/id00000015503208