Ocata Therapeutics Inc fka OCAT

[rocky301]

mail,

since injunction was posted many questions are coming in. Hope the following helps.

1)The injunction has no bearing on FDA lifting clinical hold. If lifted, ACT can pursue clinical trials via private money. If the FFB/DoD must be involved to pursue trials then cell ine approval required, according to Lanza.

2)The MA09 cell line did NOT preserve embryos
http://investorshub.advfn.com/boards/read_msg.aspx?message_id=46769530&txt2find=divided

3)Why wouldn't the NIH approve NED(non embryo destruction) lines right away? They don't harm embryos so what is the deal?

First of all, the NED lines are only being considered by NIH now because of a proposed change to guidelines allowing early stage human embryos. Secondly, if it was cut and dried that absolutely no harm comes to embryos, it would have been done long ago. Below are a few snippets that may help put the "reasons" in perspective.

"If Bush approves the latest technique, said Lanza, researchers could get their hands on new lines of embryonic stem cells immediately. So what’s the catch? Only 80 percent of the embryos used by Lanza continued to develop. That’s comparable to the success rates seen in pre-implantation genetic diagnosis, an assisted reproduction technique during which a single cell is removed from an embryo for genetic testing. But according to Stanford bioethicist William Hurlbut, that’s not enough: the embryos are still in danger."
http://investorshub.advfn.com/boards/read_msg.aspx?message_id=44113465&txt2find=Dickey

(slide 83 from NIH)
hESC Lines from Single Cell Embryo Biopsy
In 2006, Dr. Robert Lanza and colleagues demonstrated that it is possible to remove a single cell from a pre-implantation mouse embryo and generate a mouse ES cell line.21 This work was based upon their experience with cleavage-stage mouse embryos. Later that same year, Dr. Lanza’s laboratory reported that it had successfully established hESC lines (see Figure 8.3e) from single cells taken from pre-implantation human embryos.22 The human stem cells created using this technique behaved like pluripotent stem cells, including making proteins critical for “stemness” and producing cells from all three germ layers. Proponents of this technique suggest that since it requires only one embryonic cell, the remaining cells may yet be implanted in the womb and develop into a human being. Therefore, scientists could potentially derive human embryonic stem cells without having to destroy an embryo. However, ethical considerations make it uncertain whether scientists will ever test if the cells remaining after removal of a single cell can develop into a human being, at least in embryos that are not at risk for carrying a genetic disorder. Moreover, it is unclear whether the single cell used to generate a pluripotent stem cell line has the capacity to become a human being.
http://stemcells.nih.gov/staticresources/info/scireport/PDFs/chapter8.pdf