NanoViricides Inc. (NNVC)

[Ubertino]

SELF ASSEMBLING AMPHIPHILIC POLYMERS AS ANTIVIRAL AGENTS

United States Patent Application 20100008938

Diwan; Anil ; et al. January 14, 2010

Abstract
There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds and disrupting viral coat proteins. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties which mediate adherence of the aggregate to a viral target.

Inventors:
Diwan; Anil; (West Haven, CT) ; Onton; Ann Louise; (Fairfield, CT) ; Tatake; Jayant G.; (Sandy Hook, CT)

Serial No.: 518411
Series Code: 12
Filed: January 22, 2007
PCT Filed: January 22, 2007
PCT NO: PCT/US07/01607
371 Date: June 9, 2009

Claims

1. A method for the treatment or prevention of an infection of an animal by a virus, which comprises administering to said animal a comb polymer consisting essentially of the following structure: ##STR00020## comprising a backbone formed of alternating branch-point moieties B and hydrophilic, water-soluble polymer blocks A; and having hydrophobic side chains C and ligands Z attached to the branch-point moieties, wherein:each hydrophobic side chain C is independently selected from the group consisting of C.sub.6-C.sub.30 linear or branched hydrocarbons optionally substituted with one or more hydrophilic substituents; C.sub.6-C.sub.30 cyclic or polycyclic hydrocarbons optionally substituted with one or more hydrophilic substituents; and hydrophobic amino acids, peptides and polymers;each ligand Z is independently a ligand having specific binding affinity for the surface of said virus;s is a bond or a spacer moiety;the value of n ranges from 3 to about 100;the average value of p ranges from greater than one to four; andthe average value of r ranges from 1 to 8.

http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1=%2220100008938%22.PGNR.&OS=DN/20100008938&RS=DN/20100008938