Achilles Therapeutics Plc (ACHL)

[jondoeuk]

It could,* but as I said still think the product doses, cell phenotype(s) and neoantigen-reactivity will play a role as well. There is data from different groups to support that.

As for the innate arm, it would be interesting to test single and dual CARs against PD-L1 and HLA-G in a select patient population https://aacrjournals.org/cancerres/article/83/7_Supplement/5965/724047/Abstract-5965-B2M-loss-of-heterozygosity-in https://elifesciences.org/articles/54854

* Back in the 2000s, Dr Rosenberg's group the US NCI tested three consecutive protocols (in patients with metastatic melanoma) to increase the levels of lymphodepletion. In the first protocol, 43 patients were treated with TIL following the administration of a non-myeloablative chemo regimen consisting of cy/flu. A second trial was then conducted in 25 patients in which the same chemo was given followed by 200cGy whole body irradiation the day before TIL administration. In a third trial in 25 patients, the total body irradiation was intensified for a total of 1200cGy. In the latter two trials, circulating CD34+ haematopoietic stem cells were administered. In all protocols high-dose IL-2 was given as well. The ORR in the three sequential protocols were 49%, 52% and 72%, respectively.