SeaStar Medical Holding Corp (ICU)

[theswordman]

SeaStar and SCD getting a shoutout TODAY in Extracorporeal Organ Support for Burn-Injured Patients issue of Medical Sciences by MDPI.

5.3. Cell-Directed Extracorporeal Therapy
The Selective Cytopheretic Device (SCD) (SeaStar Medical, Denver, CO, USA), is a technology that sequesters and modulates the most activated neutrophils and monocytes . The SCD is a biocompatible membrane that mimics capillary blood flow and sequesters activated leukocytes. The SCD is utilized in conjunction with CKRT, with the SCD downstream from the CKRT hemofilter in the circuit. The SCD requires the use of regional citrate anticoagulation to induce hypocalcemia within the SCD, which results in both the inhibition of the clotting cascade but also the inactivation of leukocytes. There are a number of smaller studies in critically ill medical patients which have shown promising results, but there are limited data including burn patients . A multicenter randomized controlled trial, NEUTRALIZE-AKI, is currently enrolling critically ill patients with AKI, who require CKRT .

https://www.mdpi.com/2673-1991/5/2/6