AstraZeneca PLC (AZN)

[jondoeuk]

The company has inked a non-exclusive licensing deal with Revvity to use its Pin-point base editing platform in the development of new cell therapy treatments for cancer and other immune-mediated diseases. Pin-point uses a novel three-part design with an RNA aptamer guide, a modified Cas9 enzyme and a deaminase enzyme.

The platform is highly efficient and precise, allowing for multiplex editing with >75% editing in each target base. Also, has a strong safety profile with negligible off-target edits and no translocations. In addition, has no impact on cell health and allows for one-step complex engineering, which is simultaneous multiple knock-ins and knockouts (at least seven).