SiNtx Technologies Inc (SINT)

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Investigation of metal deposition in organs after joint replacement

This study was the first to combine the use of micro X-ray fluorescence and micro X-ray absorption spectroscopy to probe the distribution and chemical form of cobalt, chromium and titanium in organ tissue samples from patients who had been given MOP hip implants.

Their results suggest that chronic diseases, such as diabetes, may create conditions in which mildly toxic trivalent chromium (CrIII) particles from replacement joints are reoxidised within the body to form carcinogenic hexavalent chromium (CrVI)

https://phys.org/news/2018-03-metal-deposition-joint.html


Molecular analysis of chromium and cobalt-related toxicity

Metallic ions and corrosion products were also generated in vitro following macrophage phagocytosis of metal alloys. Ex vivo redox proteomic mapped several oxidatively damaged proteins by Cr(III) and Co(II)-induced Fenton reaction. Importantly, a positive correlation between the tissue amounts of Cr(III) and Co(II) ions and tissue oxidative damage was observed. Immobilized- Cr(III) and Co(II) affinity chromatography indicated that metal ions can also directly bind to several metallo and non-metalloproteins and, as demonstrated for aldolase and catalase, induce loss of their biological function. Altogether, our analysis reveals several biological mechanisms leading to tissue damage, necrosis, and inflammation in patients with Cr and Co-associated adverse local tissue reactions.

https://www.nature.com/articles/srep05729