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Post# of 2020
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bow-tie

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bow-tie

Re: None

Saturday, 12/16/2017 12:21:22 PM

Saturday, December 16, 2017 12:21:22 PM

Post# of 2020
More on Crotoxin: Walker 256 found: In conclusion, CTX, the main neurotoxic component of Crotalus durissus terrificus venom, reduced Walker 256 tumor growth possibly due to an antiangiogenic effect. LXA4 and 15-epi-LXA4 are involved in the antitumor effects of CTX. The FPRs played a key role in the effect of the CTX on tumor growth. These receptors mediated the increase in plasma levels of LXA4 and 15-epi-LXA4 and also the actions of the lipid mediators.

Highlights of this paper are as follows:
(i)
Crotoxin, South American rattlesnake (Crotalus durissus terrificus) venom.
(ii)
Antitumoral activity.
(iii)
Mechanisms of action: plasma concentrations of lipoxin A4 and its natural analogue 15-epi-LXA4, LXA4/15-epi-LXA4 release; inhibition of both tumor growth and formation of new vessels via FPRs.

https://www.hindawi.com/journals/mi/2016/2457532/
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