Vascular Biogenics Ltd (VBLT): Regarding survival data for PrOC. h...

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Re: wcopeland post# 1685

Saturday, 11/25/2017 2:29:18 PM

Saturday, November 25, 2017 2:29:18 PM

Regarding survival data for PrOC.

https://am.asco.org/quality-life-may-predict-survival-platinum-resistant-or-platinum-refractory-recurrent-ovarian-cancer

570 patients with PrOC. Just over half with primary ovarian cancer. Median OS was 11.1 months (roughly 340 days). It should be noted that ECOG status for these patients were overwhelmingly great or excellent.

The VBLT ASCO 2016 presentation found 810 days for high-dose and 172 days for low-dose. As you can see, the 4 low-dose patients resulted in a significant underestimation of what other trials have shown. I would take both the high and low with a grain of salt.

I will be interested to see how they power Ph3 PrOC. If enough patients and they reach a mOS on the order for 450-600 days, that should still be significantly improved over a historical average of 340 days.

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