Innovation Pharmaceuticals Inc (IPIX)

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Chemotherapy-Induced Oral Mucositis Treatment & Management

Updated: Jun 22, 2017

Author: Nathaniel S Treister, DMD, DMSc; Chief Editor: Jeff Burgess, DDS, MSD


“Prophylaxis/prevention

Cryotherapy with ice chips has been shown to effectively attenuate the onset and severity of mucositis in patients undergoing bolus chemotherapy with 5-fluorouracil and melphalan. Patients should suck on ice chips for 30 minutes prior to and during the chemotherapy infusion. Palifermin (keratinocyte growth factor) is FDA approved for the prevention of oral mucositis in patients undergoing HCT with myeloablative conditioning (see below). Antimicrobial prophylaxis is generally limited to antivirals to prevent herpes simplex virus (HSV) reactivation; however, some centers use fluconazole as prophylaxis against candidiasis. Neither antiviral nor antifungal prophylaxis prevents mucositis. Increasing evidence supports the effectiveness of photobiomodulation therapy (low-level laser therapy) for the prevention and management of oral mucositis, but its use remains limited. Regimens, including laser wavelength and intensity, have varied considerably from study to study, and specialized equipment is required.”


https://emedicine.medscape.com/article/1079570-treatment#d1