Kitov Pharmaceuticals Hldgs L Sponsored ADR (KTOV)

[EM]

RENAL RESULTS

Why so important?

https://www.huffingtonpost.com/entry/arthritis-drugs-and-kidney-disease_us_599dbfbde4b0b87d38cbe6da

"According to a recent report, the use of these NSAIDs increase the risk of acute kidney injury by 50% in the general population and patients with chronic kidney disease (CKD). The report also estimated that the incidence of acute kidney injury doubled in patients over 50 compared to those that did not take NSAIDs".

Why did Kitov Pharmaceuticals do this precision study?


From recent 20-F ....
https://www.sec.gov/Archives/edgar/data/1614744/000121390017004462/f20f2016_kitovpharma.htm

"Additional data from the (FIRST) Phase III clinical trial of KIT-302 also suggest beneficial effects on renal (kidney) function, as compared to negative effects on renal function caused by other NSAIDS. Greater reduction in plasma levels of creatinine was observed in patients in the KIT-302’s two components arm (-3.22 umol/L) compared to creatinine reduction observed in patients in the amlodipine arm (-2.55 umol/L), suggesting better renal function. In addition, peripheral edema, a known side effect of calcium channel blockers such as amlodipine, was reported in 15.6% of patients receiving amlodipine alone, but in only 8.2% of patients receiving KIT-302’s two components, suggesting that KIT-302 may protect against the amlodipine side effect of causing fluid retention by the kidneys".

Yesterday, these beneficial effects on renal (kidney) function have been confirmed!
https://www.prnewswire.com/news-releases/kitov-pharmaceuticals-announces-phase-iiiiv-clinical-trial-for-kit-302-successfully-meets-primary-endpoint-and-also-demonstrates-drug-candidate-improves-renal-function-653388493.html

"The study also demonstrated that treatment with KIT-302 led to a statistically significant reduction of serum creatinine, a marker of renal function, from its baseline value (p=0.0005). In contrast, neither amlodipine besylate nor placebo lowered creatinine to a statistically significant level".
.... Furthermore, "the peripheral edema measure, a known side effect of calcium channel blockers such as amlodipine, was statistically INSIGNIFICANT".

Now they proved that KIT-302 is the first NSAIDs with NO cardiovascular risks and NO negative effects on renal functions!