Yeah I generally go for the "double and cover" approach. Buy 10 mil then sell 5, or 5 and sell 2.5, etc. I then take profits at other target exits. Did the same with Litecoin but am still holding most of it.
Like for ONCI, bought at .0007, covered at .0015, took a large profit at .0098, another target exit at .037, then another at .095 if it ever gets there. After that I'd still have a few shares just in case, but not much. Also did very well on ARYC, got all the way out at .013 and it has since fallen.
For DD, I honestly don't do a whole lot, I pretty much just check reverse split history and past charts. I also read the boards and check PRs and social media activity. I've gotten stuck in a couple but most have worked out, and they may pop someday. I am looking at CWIR and FRCN right now.