Anavex Life Sciences Corp (AVXL)

[blu_1]

I suspect these similar age related diseases have build up of oxidative stress as the commonality. 2-73 addresses that through modulating ca++ across the plasma membrane and membranes of the intracellular organelles (ER, mitochondria).

What's your take on Aducanumab's results written up in Nature last August? Supposedly, at the highest dose given in the Ph 1b trial, all the amyloid/a-beta was removed from the brain and cognitive decline was slowed or halted (I'm not sure which was case). High incidence of brain swelling, esp for patients on the highest dose (10mg), tho Biogen said that swelling resolved in the patients during the trial. Not sure if it is of consequence. 40% drop out rate during the trial for various side effects. Trial only involved patients with MCI and mild Alzheimers. Biogen feels the key is giving the drug early before neuron death happens. The drug is a shot given once/month and would cost about $40K/year. Their next trial for the drug should finish 2020 at the earliest and enrolls 1350 patients in the UK.