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Re: dia76ca post# 2141

Wednesday, 06/14/2017 12:40:52 PM

Wednesday, June 14, 2017 12:40:52 PM

Post# of 6034
As well as improving the May 30 company presentation with a sharp focus on turning COLD tumours into HOT...they seem to have cleaned up the website to indicate the focus on HS-110...removing a section on HS-410 which is now clearly on the back-burner. See...

http://www.heatbio.com/pipeline/hs-110

They seem also to have, if my memory serves me, renewed interest in the phase II HS-110 plus low dose cyclophosphamide trial. While this trial does not include a checkpoint inhibitor...low dose CP has been used in a number of CAR-T trials as a primer as it shifts the immune system balance in favour of attacking the tumour. I could easily foresee a triple combination low dose CP + HS-110 + checkpoint inhibitor trial as one of the next combination trials.

"The refusal of the real is the number one dogma of our time" Rene Girard

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