Thursday, March 23, 2017 3:35:50 PM
I value kld2's careful approach even though I have quite different approach. In my opinion he discusses very well and helps everyone by bringing up slightly different point of view and doing it very constructively.
That being said I would still like to point out that compassionate use patients are real people and offer similar (but deeper) data than what the company gets from trial patients. So we need to consider them carefully and try to understand what that data tells us.
I have said it before but I say it again. Those patients had kind of treatment effect almost no-one has ever had or at least there are very few reports available about anything similar (to my knowledge). The fact it happened more than once and apparently to all patients just makes it multiple times more rare.
So the question in my mind is not so much whether Bryostatin can have dramatic efficacy in AD patients but whether it can have that effect in some, most or all patients. IMO that's the question.
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