NorthWest Biotherapeutics Inc (NWBO)

[Barunuuk]

Difference between median and average. However, I will show you that if those 51 patients were included in the DCVax-L study, the median value would have gone up, not down, and subsequently the same for ICT-107.

AVII you are correct, the 51 patients have a median OS of 18 months, now that is less than the 20-21 months of ICT-107. However, unless you are calculating the average OS value, these would slightly increase the OS median, and here is why.

Lets assume that for the four groups, all patients have the median OS value for simplicity however it wouldn't matter (and you will see why). So we have:

20 Rapid Progressors all at 15.3 months
5 Unclassified Patients at 9.2 months
25 Indeterminate Patients at 21.5 months
1 Pseudoprogrssor at 30.1 month.

Now if the median OS before adding these was 21 months, the 25 patients with OS < than the median 21 months would be offset by the 25 Indeterminate Patients at 21.5 months, and then the extra pseudoprogressor would then mean the new median would be the next patient with OS > 21 months. So the new median OS would be 21.2 months (or whatever that was).

Anyways, as such, because there is ~ 50-50 split, it would have little to no impact on the median value. On the average value, yes, but not the median value. Hope that helps.