Innovation Pharmaceuticals Inc (IPIX)

[georgejjl]

Cellceutix is consulting with a world renowned expert on p53 and a member of the National Academy of Sciences who helped design the study, which is intended to provide potential partners key information on the mechanism of action of the novel compound.

Arnold Levine, PhD, (PI, Core B) is Professor of Natural Sciences at the Institute for Advanced Study, (IAS) Princeton NJ and Professor of Pediatrics and Biochemistry at the Cancer Institute of New Jersey, at the Robert Wood Johnson Medical School, Brunswick, NJ. He discovered the p53 protein, and demonstrated its association with the oncogenic products of 3 major DNA tumor viruses (SV40, Adenovirus and Human Papillomaviruses). Levine showed that p53 binds to the Mdm2 oncoprotein, and forms an autoregulatory loop with Mdm2. His mutational analysis of the p53 protein provided insight into its transcriptional activation functions. He was the first to provide experimental evidence in a xenograft mouse model that tumor derived mutant forms of p53 have pro-oncogenic activities. More recently, he has investigated the role of Single Nucleotide Polymorphisms (SNPs) in the p53 pathway and discovered a SNP in the human Mdm2 promoter that results in high expression of Mdm2 and dampened p53 response and showed that some cohorts of individuals with the high Mdm2 expression allele have earlier onset of cancers. His recent work also revealed that p53 regulates fertility in mice and humans. Dr Levine, a member of the National Academy of Sciences, has received, major awards for his contributions (eg. Bristol Myers Squibb, General Motors Mott Prize, the ACS Medal of Honor and others), and has served on many editorial and advisory boards.

http://p53.biology.columbia.edu/team/

Good luck and GOD bless,

George