So long as the majority of MAC events are happening in the placebo group then its a positive.....the futility analysis takes place after 125 MAC events, (half of the 250 total for a completed trial) and the best case scenario in my view would be 0 in the Apabetalone arm and 125 for those taking placebo.
Obviously that's probably incredibly unrealistic as an expectation....but it goes without saying that the fewer events in the dosed arm the better.
If you want to taste the fruit, you have to go out on a limb. But if you wait for the herd to move out on the limb....the branch tends to snap.
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