ProMIS Neurosciences : Declares PMN 310 its First Lead Product for Development in Alzheimers Disease
ProMIS Neurosciences : Declares PMN 310 its First Lead Product for Development in Alzheimers Disease
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01/06/2017 | 01:14pm CET
(PRWeb) - ProMIS Neurosciences (ProMIS or the Company), a company focused on discovery and development of precision treatments for neurodegenerative diseases, today announced that PMN 310, a monoclonal antibody (mAb), has been designated its first lead product for development in Alzheimers disease (AD).
We previously demonstrated that the mAb therapeutic candidates ProMIS is developing display the optimal target profile of selectively binding prion-like forms of A and inhibiting both their propagation (spreading) and neurotoxicity in laboratory tests (in vitro), stated Dr. Neil Cashman, ProMIS Chief Scientific Officer. We have now achieved a significant development milestone by demonstrating that PMN 310 directly blocks the neurotoxicity of these prion-like forms of (A) in a well validated mouse model.
The neuroprotective effect of PMN 310 was investigated at a well recognized contract research organization (CRO) specializing in neurodegenerative diseases. Injection of prion-like forms of A (also called toxic oligomers) into the brains of mice causes a neurological deficit that can be assessed in a memory-behavior test called novel object recognition. Normal mice exposed to an object remember the familiar object when re-exposed to it and spend more time exploring a newly introduced object. In contrast, oligomer-injected mice lose the ability to discriminate between known and novel objects and spend equivalent amounts of time exploring both. Results obtained in this assay showed that administration of PMN310 to mice completely prevented the loss of short-term memory formation caused by toxic oligomers.
The past year has been devoted to characterizing our mAbs with a view to select and prioritize our therapeutic candidates for AD; these compelling in vivo results have led us to declare PMN 310 our first lead product for development in AD, commented Eugene Williams, ProMIS Executive Chairman. Furthermore, the animal model used is particularly relevant to recent scientific developments that toxic prion-like forms of A are the appropriate target for therapy, and to our knowledge, PMN 310 is the first mAb specifically designed to address this target.
