Cytodyn Inc (CYDY)

[jboatswain]

Thank you for your info on Maraviroc.

Maravirac:
- small molecule CCR5 antagonist
- serious side effects
- twice a day pill


Pro 140
- mAb CCR5 antagonist
- no serious side effects
- weekly subcutaneous injection

I am still interested in underlying causes of PRO 140 faring well when compared to MVC. Will try to find out soon.

From Wiki:

Two randomized, placebo-controlled clinical trials, known as MOTIVATE 1 & 2, compared 209 patients receiving optimized therapy plus a placebo to 426 patients receiving optimized therapy plus 150 mg maraviroc once daily and 414 patients receiving optimized therapy plus 150 mg maraviroc twice daily. At 48 weeks, 55% of participants receiving maraviroc once daily and 60% of participants receiving the drug twice daily achieved a viral load of less than 400 copies/mL compared with 26% of those taking placebo; about 44% of the once-daily and 45% of the twice-daily maraviroc group had a viral load of less than 50 copies/mL compared with about 23% of those who received placebo. In addition, those who received the entry inhibitor had a mean increase in CD4+ cells of 110 cells/µL in the once-daily group, 106 cells/µL in the twice-daily group, and 56 cells/µL in the placebo group.[12][13][14]