Synaptogenix Inc (SNPX)

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Total synthesis

The low concentration in bryozoans (to extract one gram of bryostatin, roughly one tonne of the raw bryozoans is needed) makes extraction unviable for large scale production. Due to the structural complexity, total synthesis has proved difficult, with only a few total syntheses reported so far. Total syntheses have been published for bryostatins 1, 2, 3, 7, 9 and 16.[13][14][15][16][17][18][19] Among them, Krische’s total synthesis of bryostatin 7 via C-C bond forming hydrogenation[17] is the shortest synthesis of any bryostatin reported, to date.

A number of structurally simpler synthetic analogs also have been prepared which exhibit similar biological profile and in some cases greater potency, which may provide a practical supply for clinical use.[20]

Investigations on how bryostatin 1 behaves in a unique fashion are ongoing in several laboratories.[21]

https://en.wikipedia.org/wiki/Bryostatin#cite_note-NCT02431468-12