Avid Bioservices Inc (CDMO)

[biopharm]

Prof. Vincenzo Bronte Head of Department of Immunology Faculty of Medicine University of Verona Italy

http://ispb.univ-lyon1.fr/la-faculte/actualites/conference-myeloid-derived-suppressor-cells-in-cancers-7th-of-december-15h00-salle-mediatheque-paul-zech-868708.kjsp

Prof. Bronte was awarded in 2007 by the Accademia Nazionale dei Lincei (Rome, Italy) in 2008 by the Italian Foundation for Cancer Research for his oncology researchers. Prof. Bronte’s major achievements is the definition and molecular characterization of immunoregulatory cells, now called myeloid-derived suppressor cells (MDSCs), whose negative influence on antitumor immunity represents an obstacle to a successful immunotherapy of cancer. Current projects in the laboratory are further exploring the interplay between transformed cells and the surrounding stroma.

http://ispb.univ-lyon1.fr/la-faculte/actualites/conference-myeloid-derived-suppressor-cells-in-cancers-7th-of-december-15h00-salle-mediatheque-paul-zech-868708.kjsp


Looks like we are being told time and time and.... time again how Myeloid Derived Suppressor Cells are a BIG WARNING SIGN that you are not going to have a good chance with any FDA approved Immunotherapy such as Opdivo or Keytruda ...etc with high levels of MDSC's.

This is the reason why... or I should say why Peregrine initially suspected this and was able to attract the attention of the MD of MDSC's, the MD who coined the term and spent his life researching them... ==> Dr. Dmitry Gabrilovich that was brought on as a KOL in Dec of 2013

MDSC as predictors of clinical outcome in cancer:

Melanoma:

* Clinical responders to ipilimumab therapy showed significantly less MDSC as compared to non-responders. MDSC may be used as predictive marker of response

* Frequency of MDSC correlated with disease progression and decreased overall survival.

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http://investorshub.advfn.com/boards/read_msg.aspx?message_id=104605941

We have hear this now from many sources, direct ties to Peregrine Pharmaceuticals and things are becoming quite clear current shareholders are being slow played it seems and there is no need for it and IF there is... Peregrine should be half way thru wrapping up a nice long letter to the shareholders describing the off shore difficulties that may exist