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$PMCB PharmaCyte Biotech Cannabinoid Research Shows Promise for Success

LAGUNA HILLS, Calif., Oct. 10, 2016 (GLOBE NEWSWIRE) — PharmaCyte Biotech, Inc. (OTCQB:PMCB), a clinical stage biotechnology company focused on developing targeted treatments for cancer and diabetes using its signature live-cell encapsulation technology, Cell-in-a-Box®, today announced that it has advanced into a new and promising phase of research at the University of Northern Colorado (UNCO) in its quest to develop targeted cannabinoid-based chemotherapy utilizing the Cell-in-a-Box® technology.
“The work at UNCO is just one of the programs actively underway at PharmaCyte,” commented the Chief Executive Officer of PharmaCyte, Kenneth L. Waggoner. “With our preliminary work complete, we are now looking forward to the possibility of making significant progress in the development of targeted cannabinoid-based chemotherapy. The approach being used for our cannabinoid-based chemotherapy is the same as we are using for our pancreatic cancer therapy.”
Utilizing data collected from recently-completed preliminary studies, a new research protocol has been undertaken to deliver anti-cancer cannabinoid molecules like cannabidiol (CBD) and tetrahydrocannabinol (THC) to solid tumors in a targeted fashion. PharmaCyte has identified a naturally-occurring enzyme that it believes is capable of converting specific cannabinoid prodrugs into cancer-fighting forms. The exact gene code of this enzyme has been sequenced.
Knowing the gene code, it is possible to synthesize the gene. The gene may then be inserted or “transfected” into the genetic code of live human cells. The bioengineered cells may then be grown in culture and tested for their cannabinoid prodrug activating ability. This work is currently in progress. If sufficient prodrug activation is detected, PharmaCyte plans to move directly to live-cell encapsulation using its Cell-in-a-Box® platform technology and pre-clinical testing with various cancer models.
The goal is to implant encapsulated bioengineered cells at the site of a tumor and then to administer the cannabinoid prodrug into a blood vessel near the tumor. The enzyme produced by the live cells within the capsules would activate the prodrug in a targeted fashion, initiating cancer cell death. Such an approach should maximize effectiveness and minimize side effects from this form of chemotherapy.
“We are quite pleased with the progress UNCO has made and to have all the necessary components in place to advance our research,” commented cannabinoid medicine expert and member of PharmaCyte’s Medical and Scientific Advisory Board, Dr. Mark L. Rabe. “Having a candidate enzyme and knowing the gene behind it is huge. It is now a matter of completing a series of steps and making sure everything we have planned works. If so, it is a fairly straight line to the clinic. Our initial goal is to tackle glioblastoma, an almost untreatable form of brain cancer.”

http://pharmacyte.com/pharmacyte-biotech-cannabinoid-research-shows-promise-for-success/