Intellipharmaceutics International Inc. (IPCI)

[WeeZuhl]

You require remediation on food dyes.

100% pure and utter nonsense as the FDA's APPROVED color additive list for DRUGS, food and cosmetic products is 100 miles long hahahahhaahhaa>>>

www.fda.gov/ForIndustry/ColorAdditives/ColorAdditiveInventories/ucm106626.htm

http://www.fda.gov/ForIndustry/ColorAdditives/RegulatoryProcessHistoricalPerspectives/

Allow me to clear up your misunderstanding/misinformation. While there are 100's of certified combinations and types of color batches, there are fewer than 10 synthetic dyes for color, and only 2 blues are currently approved for human use. Blue #1 is much more likely choice, but it could be Blue #2. Natural tints or novel tints would require special use permission. All of the testing of dyes for safety have been done in healthy adults, but the demonstrated problem with enteral exposure of blue dye is in UNHEALTHY SEPTIC ADULTS.



http://www.nejm.org/doi/full/10.1056/nejm200010053431416#t=article

FD&C blue dye no. 1 was approved by the FDA for use in food after experiments showed that the dye was nontoxic and was not absorbable. However, these experiments were performed in healthy animals. Artificial food dyes can inhibit mitochondrial oxidative phosphorylation in vitro by acting as uncouplers (as does 2,4-dinitrophenol), by blocking electron transport (as does cyanide), or by inhibiting energy transformation by blocking the generation of ATP. Blue dye no. 1, a triphenylmethane dye, is a potent inhibitor of mitochondrial respiration in vitro and reduces oxygen consumption by a factor of eight in mitochondrial preparations in vitro. It appears to inhibit energy transformation by blocking the adenine nucleotide translocator (as is the case with atractyloside).

http://www.fda.gov/ForIndustry/ColorAdditives/ColorAdditivesinSpecificProducts/InMedicalDevices/ucm142395.htm

Other blue dyes, such as methylene blue and FD&C Blue No. 2, may have similar if not greater toxicity potential than Blue 1 and would not be appropriate replacements.