Clinuvel Pharmaceuticals (CLVLY)

[FarmaZutical]

To my knowledge DMSO is not yet approved by the FDA for conditions other than a bladder disorder even though it is know to have the properties you mention. I don't think Clinuvel would use a compound surrounded by such controversy as DMSO given the fact that Scenesse is already a controversial compound.

Usually, the 500 dalton rule apply to any compound that's supposed to penetrate the skin. Scenesse is above 1600 daltons and thereby unable to penetrate the dermis. CUV9900 is 900 daltons but I don't know what VLRX001 is.

Maybe VLRX and / or CUV9900 is only supposed to penetrate the epidermis and not the dermis in order to reach the melanocytes. Perhaps that would make the dalton issue of less importance.

Also, other researchers have made strides in developing methods to penetrate the dermis.

Abdel-Malek claims to have successfully made a melanocortin analogue penetrate he skin of mice and Ken Kirby also did this many years ago if I remember it correctly.

Clinuvel is not revealing much in order to protect the IP so I guess we'll have to wait and see how they do it till they are further ahead with the development.