Arbutus Biopharma Corporation (ABUS)

[Ubertino]

United States Patent 9,404,127
Yaworski , et al. August 2, 2016

Non-liposomal systems for nucleic acid delivery

Abstract
The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.

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