Friday, July 15, 2016 12:10:51 AM
IPA - CNS INFLAMMATION
http://www.nature.com/nm/journal/v22/n6/images/nm.4117-F1.jpg ">
http://www.nature.com/nm/journal/v22/n6/images/nm.4117-F1.jpg " />
Following the consumption of such foods, bacteria in the gut catabolize tryptophan into a range of indole derivatives (such as indole-3-acetic acid, indoxyl-3-sulfate, indole-3-propionic acid and indole-3-aldehyde) that are ligands for the aryl hydrocarbon receptor (AHR). Activation of AHR in gut-resident T cells and in innate lymphoid cells (ILC) enhances production of IL-22 (orange circles), which protects against inflammation in the colon (colitis). Tryptophan metabolites also have systemic effects, and signaling through the AHR in astrocytes influences a type 1 IFN signaling pathway, which culminates in both reduced NF-?B-driven inflammation (via SOCS2) and reduced CNS autoimmunity.
http://www.nature.com/nm/journal/v22/n6/fig_tab/nm.4117_F1.html
http://www.nature.com/nm/journal/v22/n6/images/nm.4117-F1.jpg ">
Following the consumption of such foods, bacteria in the gut catabolize tryptophan into a range of indole derivatives (such as indole-3-acetic acid, indoxyl-3-sulfate, indole-3-propionic acid and indole-3-aldehyde) that are ligands for the aryl hydrocarbon receptor (AHR). Activation of AHR in gut-resident T cells and in innate lymphoid cells (ILC) enhances production of IL-22 (orange circles), which protects against inflammation in the colon (colitis). Tryptophan metabolites also have systemic effects, and signaling through the AHR in astrocytes influences a type 1 IFN signaling pathway, which culminates in both reduced NF-?B-driven inflammation (via SOCS2) and reduced CNS autoimmunity.
http://www.nature.com/nm/journal/v22/n6/fig_tab/nm.4117_F1.html
Things that are equal to the same thing are also equal to one another (Transitive property of equality). If equals are added to equals, then the wholes are equal. If equals are subtracted from equals, then the remainders are equal. Things that coincide wi
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