The cross talk between the HRS cells and the cells of the tumor microenvironment supports cHL growth and survival. Whether the HRS cells drive and sustain their microenvironment, or the inflammatory microenvironment itself stimulates the development of the HRS cells is unknown.
http://www.hematologyandoncology.net/index.php/archives/august-2015/hodgkin-lymphoma-targeting-the-tumor-microenvironment-as-a-therapeutic-strategy/
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