Trillium Therapeutics Inc (TRIL)

[NY1972]

TSP1

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013442#pone.0013442-Thirman1

Taking advantage of cell culture system and zebrafish model, we have identified that ELL could serve as a transcriptional factor to directly up-regulate TSP1 expression [31]. ELL was first identified in acute myeloid leukemia as a translocation partner of MLL. Like other MLL translocation products, the chimera MLL-ELL appears to play an important role in leukemogenesis [32], [33], [34], [35], [36]. These findings link the TSP1 with another kind of cancer progression—leukemogenesis, unrelated to its role in anti-angiogenesis.