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OncBioMune Research Shows Activity of PGT Technology in a Mammary Cancer Animal Model



BATON ROUGE, LA--(Marketwired - July 06, 2016) - OncBioMune Pharmaceuticals, Inc. (OBMP) ("OncBioMune" or the "Company"), a clinical stage biopharmaceutical company engaged in the development of novel cancer products and a proprietary vaccine technology, is pleased to inform shareholders of results of pre-clinical research that support further development of the Company's patented, novel paclitaxel gallium transferrin (PGT) technology for the treatment of multiple types of cancer.


OncBioMune first tested PGT against a series of human cell lines to evaluate activity in models of breast, colon, lung and three human cell lines of ovarian cancer, including a drug-resistant ovarian cancer model. The results showed PGT to act as an inhibitor of all tumor cell lines, including the drug-resistant ovarian cancer model.

OncBioMune then conducted research to develop an animal model to evaluate the activity of PGT and selected the 4T1 murine mammary carcinoma tumor model. The 4T1 murine mammary carcinoma is recognized as one of the most aggressive cancer cell lines and is known to rapidly metastasize to sites similar to human breast cancer. OncBioMune developed its own 4T1 mouse model and showed an intraperitoneal injection of PGT worked as an inhibitor of 4T1 mammary tumors. Importantly, no gross organ toxicities at necropsy were observed.

"These early studies demonstrated that our PGT technology has a wide spectrum of activity against several difficult to treat cancers," commented Dr. Jonathan Head, Chief Executive Officer at OncBioMune. "The data warrants additional research as we continue to widen our pipeline with cancer drug candidates. We are pleased with all the data and particularly impressed with the results in the drug-resistant ovarian cancer cell line. We believe there are several opportunities to explore FDA pathways to expedite development for this indication."

OncBioMune's PGT technology is being developed to overcome shortfalls in commonly used, FDA-approved taxane therapies, such as paclitaxel and docetaxel, for treatment of an array of cancers. PGT technology utilizes a novel composition of a protein and a taxane without Cremophor or a linking group to improve the delivery method and target the chemotherapeutic agent to the tumor resulting in greater specificity without toxicity.

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